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Trine Klette May Britt Drugli Ann Mari Aandahl 《Early child development and care》2018,188(3):387-398
The study investigated the quality of interactions between childcare providers and toddlers during a lunch in childcare centres. Meals in childcare centres are semi-structured adult-led situations where the children not only eat, but are also provided with opportunities for implicit learning and interactions. Participants were 13 toddlers aged about 18 months in 11 different childcare centres in a Norwegian municipality. Video recordings were analysed for organization and structure, relational climate and childcare provider–child interactions, weighting provider sensitivity, language support and facilitated exploration. Findings indicated good quality regarding the organization of meals and relational climate in about half of the centres. Sensitivity, language support and facilitated exploration showed low quality across the different centres and are a cause for concern. Implications of the findings are discussed. 相似文献
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The prognostic relevance of the mitotic activity index in axillary lymph node-negative breast cancer
Jobsen Jan J. van der Palen Job Brinkhuis Mariël Nortier Johan W. R. Struikmans Henk 《Breast cancer research and treatment》2015,149(2):343-351
Breast Cancer Research and Treatment - The aim of the present study is to look at the mitotic activity index (MAI) as a prognostic factor in a prospective population-based cohort of lymph... 相似文献
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Tsubasa Hiraki Miho Hatanaka Akiko Arimura Hisao Kawahira Mari Kirishima Ikumi Kitazono Michiko Horinouchi Michiyo Higashi Takuro Kanekura Akihide Tanimoto 《Journal of cutaneous pathology》2020,47(2):154-160
Nivolumab and pembrolizumab are humanized IgG4 monoclonal antibodies against programmed cell death 1 (PD-1). Although these agents are effective in treating advanced melanoma, non-small-cell lung carcinoma, and other types of cancers, various adverse events have been reported. Cutaneous adverse events are particularly prevalent and, while granulomatous/sarcoid-like reactions are uncommon, they are increasingly recognized as immune-related adverse events associated with immune checkpoint inhibitors. Herein, we report two cases of granulomatous/sarcoid-like reaction with foreign material, mimicking metastatic malignancy after PD-1 inhibitor treatment. Clinicians should be aware of the existence of cutaneous lesions and perform biopsy if needed to prevent misdiagnosis and unnecessary adjustments to immunotherapy. 相似文献