全文获取类型
收费全文 | 320篇 |
免费 | 24篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 6篇 |
妇产科学 | 6篇 |
基础医学 | 38篇 |
口腔科学 | 3篇 |
临床医学 | 12篇 |
内科学 | 33篇 |
皮肤病学 | 3篇 |
神经病学 | 43篇 |
特种医学 | 24篇 |
外科学 | 90篇 |
综合类 | 2篇 |
预防医学 | 13篇 |
眼科学 | 21篇 |
药学 | 20篇 |
肿瘤学 | 12篇 |
出版年
2022年 | 4篇 |
2021年 | 18篇 |
2020年 | 5篇 |
2019年 | 17篇 |
2018年 | 20篇 |
2017年 | 7篇 |
2016年 | 7篇 |
2015年 | 15篇 |
2014年 | 10篇 |
2013年 | 20篇 |
2012年 | 18篇 |
2011年 | 11篇 |
2010年 | 9篇 |
2009年 | 10篇 |
2008年 | 25篇 |
2007年 | 22篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 14篇 |
2003年 | 12篇 |
2002年 | 12篇 |
2001年 | 7篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 3篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1993年 | 1篇 |
1992年 | 9篇 |
1991年 | 6篇 |
1990年 | 3篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 5篇 |
1966年 | 1篇 |
1963年 | 1篇 |
1944年 | 1篇 |
排序方式: 共有345条查询结果,搜索用时 16 毫秒
11.
Carlos Morales-Uribe Ana Ramírez Tatiana Suarez-Poveda Margarita Ortiz Alvaro Sanabria 《Emergency radiology》2016,23(5):421-431
This study was conducted in order to define the diagnostic performance of CT angiography for vascular injuries compared with angiography in patients with neck trauma. CT angiography is the cornerstone of diagnosis for hemodynamically stable patients with wounds suspicious of vascular trauma in the limbs, chest, or abdomen. Available evidence for the use of CT angiography in neck vascular trauma comes from small case series and few randomized controlled trials, and high-quality information does not exist regarding its performance. A protocol using the recommendations of the Cochrane Collaboration was designed. A systematic search of diagnostic studies without limits on language or time was carried out to December 2014. Studies including patients with neck trauma with retrospective or prospective data collection that assessed CT angiography compared with other methods were selected. Methodological quality was assessed using the QUADAS-2 tool. A hierarchical model ROC curve and a bivariate random effects model were used for the pooled analysis. Sixteen studies were selected and reviewed, and nine studies with 693 patients were included in this review. The overall sensitivity was 97 % (95 % CI 0.77–1.00; I 2?=?65.7 % (41.4–90.0)), while the overall specificity was 99 % (95 % CI 0.93–1.00; I 2?=?0). The hierarchic ROC curve showed an area under the curve of 0.99. Publication bias was not identified in this study. CT angiography can be stated as the gold standard for diagnosing vascular injuries in hemodynamically stable patients with neck trauma. 相似文献
12.
Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty
下载免费PDF全文
![点击此处可从《Journal of applied toxicology : JAT》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Gabriel Adan Araújo Leite Marciana Sanabria Marilia Martins Cavariani Janete Aparecida Anselmo‐Franci Patrícia Fernanda Felipe Pinheiro Raquel Fantin Domeniconi Wilma De Grava Kempinas 《Journal of applied toxicology : JAT》2018,38(6):914-929
The increase of obesity, bad eating habits and the lack of physical exercises are highly related to dyslipidemias. Rosuvastatin is a lipid‐lowering drug and has been indicated to prevent cardiovascular diseases and to treat dyslipidemias due to its higher efficiency to reduce serum cholesterol concentrations. This study aimed to evaluate the reproductive adverse effects on sexual maturity due to rosuvastatin exposure in juvenile male rats during prepuberty. Three groups were randomly formed with newly weaned rats: control, whose rats received saline solution 0.9% and rosuvastatin at doses of 3 or 10 mg kg–1 day–1, administered orally by gavage, from postnatal day 21 until preputial separation (average of 45 days for controls and 49 days for statin‐treated animals), indicative of puberty onset. Male rats were maintained until sexual maturity and were killed on postnatal day 110. In the rosuvastatin‐treated groups, the results showed diminished follicle‐stimulating hormone, luteinizing hormone and testosterone concentrations, increased estradiol and prolactin concentrations, histopathologic alterations on testis and epididymis and decreased sperm quality. Moreover, statin‐exposed groups showed decreased expression of androgen receptor on testis and epididymis and lower expression of aquaporin‐9 on epididymal epithelium. In conclusion, administration of rosuvastatin to prepubertal male rats provoked long‐term hormonal deregulation and impaired reproduction at adulthood. 相似文献
13.
Ohad Ronen K. Thomas Robbins Kerry D. Olsen Ashok R. Shaha Gregory W. Randolph Iain J. Nixon Mark E. Zafereo Dana M. Hartl Luiz P. Kowalski Juan P. Rodrigo Andrs Coca‐Pelaz Antti A. Mkitie Vincent Vander Poorten Alvaro Sanabria Peter Angelos Alessandra Rinaldo Alfio Ferlito 《Head & neck》2020,42(10):3061-3071
Recent modifications in the management of well‐differentiated thyroid cancer have resulted in significant alterations in clinical approach. Utilizing a series of preoperative and postoperative risk factors involving both the patient and the disease pathology, we offer the term “staged thyroidectomy” to help organize these risk factors for patients and the endocrine team to optimize management. This approach is intended to incorporate our latest nuanced understanding of certain endocrine pathology and may serve to optimize patient outcomes. 相似文献
14.
Two aspects of codependency were investigated among 442 undergraduates. First, parental antecedents were examined by subjects completing measures of codependency, perceived parental dysfunctions (compulsivity, chemical dependency, and codependency), and parental styles (coercion, control, and non-nurturance). As expected, correlations between adult codependency and parental coercion, control, non-nurturance, and maternal compulsivity were significant. However, correlations between codependency and parental chemical dependency were not significant. A multiple regression analysis identified parental codependency and maternal coercion as significant predictors of subject codependency. To examine the second aspect of codependency, which assumes that codependency was identified over 40 years ago by Karen Horney, subjects completed a loss of self measure which correlated highly with codependency. © 1996 John Wiley & Sons, Inc. 相似文献
15.
16.
S R Poole M C Ushkow P R Nader B J Bradford J R Asbury D C Worthington K E Sanabria T Carruth 《Pediatrics》1991,88(1):162-167
Corporal punishment in school is allowed in 30 states in the United States. The American Academy of Pediatrics, together with numerous other child-advocacy groups, has reaffirmed its position that corporal punishment in schools should be prohibited by state statute in all states. This article provides background information and recommendations regarding the potential role for pediatricians in attaining this goal. 相似文献
17.
A wealth of previous studies reported pathological alterations in extrahippocampal regions in mesial temporal lobe epilepsy. Previous experimental findings have also demonstrated that the entorhinal cortex and the neocortex are damaged in different animal models of acute limbic seizures. The present study was aimed at verifying possible alterations in neocortical areas, and, in particular, structural changes of GABAergic interneurons in the sensorimotor cortex, in pilocarpine-induced chronic epilepsy in the rat. Series of sections were Nissl stained and processed for immunocytochemistry using antibodies that recognize nonphosphorylated neurofilament (SMI311), glial fibrillary acidic protein (GFAP), the calcium-binding protein parvalbumin (PV) which is expressed by a subset of cortical GABAergic neurons, the GABA transporter (GAT1), and isoform 65 of glutamic acid decarboxylase (GAD65), the GABA synthetic enzyme. Epileptic rats showed decreased cortical thickness, and diffuse gliosis was observed with GFAP antibody. Neurofilament alterations were also detected in sections processed using SMI311 antiserum. In addition, a diffuse decrease of PV, GAD65, and GAT1 immunoreactivity was observed in the sensorimotor cortex. Altered expression of PV, GAD65, and GAT1 pointed out specific neocortical disturbances in GABAergic inhibition, which could play a crucial role in seizure generation and expression. Thus, the present findings indicate that damage of GABAergic interneurons could be strictly associated with neocortical hyperexcitability in temporal lobe epilepsy. 相似文献
18.
19.
20.
Sanabria Carretero P Herranz Ortega MA Rodríguez Pérez E Goldman Tarlousky L Martín Barrera G López Santamaría M 《Revista espa?ola de anestesiología y reanimación》2004,51(2):95-99
A 15-year-old female with short intestine syndrome due to chronic intestinal pseudo-obstruction associated with kidney failure underwent a multivisceral (stomach-duodenum-jejunum-ileum-pancreas-liver) and kidney transplant. She had required parenteral nutrition for the last 5 years, with numerous complications such as sepsis from the central catheter, deep venous thrombosis, severe liver dysfunction, pancytopenia due to bone marrow failure, and severe malnutrition. Surgery lasted 15 hours and was free of complications other than hypothermia, which worsened after revascularization of the grafts. Replacement of 6 units of blood products and crystalloids was required. Biochemical and hemodynamic variables were stable, apart from the development of hypernatremia, hyperglycemia, and lactic acidosis. The anesthetic approach included preoperative assessment of problems related to chronic parenteral nutrition (liver dysfunction, coagulopathy, and restricted venous access), the prevention of hypothermia, correction of electrolyte imbalance and the acid-base status, treatment of reperfusion syndrome, and the replacement of fluids and blood products to maintain circulatory homeostasis and assure sufficient splanchnic perfusion. 相似文献