全文获取类型
收费全文 | 8378篇 |
免费 | 513篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 102篇 |
儿科学 | 585篇 |
妇产科学 | 99篇 |
基础医学 | 942篇 |
口腔科学 | 141篇 |
临床医学 | 662篇 |
内科学 | 1463篇 |
皮肤病学 | 160篇 |
神经病学 | 410篇 |
特种医学 | 204篇 |
外科学 | 1448篇 |
综合类 | 195篇 |
一般理论 | 1篇 |
预防医学 | 504篇 |
眼科学 | 238篇 |
药学 | 901篇 |
中国医学 | 42篇 |
肿瘤学 | 819篇 |
出版年
2023年 | 53篇 |
2022年 | 87篇 |
2021年 | 265篇 |
2020年 | 147篇 |
2019年 | 180篇 |
2018年 | 274篇 |
2017年 | 199篇 |
2016年 | 245篇 |
2015年 | 231篇 |
2014年 | 345篇 |
2013年 | 423篇 |
2012年 | 619篇 |
2011年 | 616篇 |
2010年 | 369篇 |
2009年 | 261篇 |
2008年 | 454篇 |
2007年 | 428篇 |
2006年 | 380篇 |
2005年 | 339篇 |
2004年 | 323篇 |
2003年 | 290篇 |
2002年 | 208篇 |
2001年 | 191篇 |
2000年 | 156篇 |
1999年 | 159篇 |
1998年 | 57篇 |
1997年 | 47篇 |
1996年 | 42篇 |
1995年 | 43篇 |
1992年 | 101篇 |
1991年 | 73篇 |
1990年 | 84篇 |
1989年 | 91篇 |
1988年 | 67篇 |
1987年 | 68篇 |
1986年 | 67篇 |
1985年 | 84篇 |
1984年 | 64篇 |
1983年 | 56篇 |
1980年 | 33篇 |
1979年 | 70篇 |
1978年 | 39篇 |
1977年 | 38篇 |
1976年 | 48篇 |
1975年 | 66篇 |
1974年 | 38篇 |
1973年 | 60篇 |
1971年 | 41篇 |
1970年 | 32篇 |
1969年 | 39篇 |
排序方式: 共有8916条查询结果,搜索用时 15 毫秒
1.
Usha Patel Manish Pandey Sadhana Kannan Tanuja A. Samant Poonam Gera Neha Mittal Swapnil Rane Asawari Patil Vanita Noronha Amit Joshi Vijay M. Patil Kumar Prabhash Manoj B. Mahimkar 《British journal of cancer》2020,123(12):1757
Background Anti-EGFR-based therapies have limited success in HNSCC patients. Predictive biomarkers are greatly needed to identify the patients likely to be benefited from these targeted therapies. Here, we present the prognostic and predictive association of biomarkers in HPV-negative locally advanced (LA) HNSCC patients.Methods Treatment-naive tumour tissue samples of 404 patients, a subset of randomised Phase 3 trial comparing cisplatin radiation (CRT) versus nimotuzumab plus cisplatin radiation (NCRT) were analysed to evaluate the expression of HIF1α, EGFR and pEGFR by immunohistochemistry and EGFR gene copy change by FISH. Progression-free survival (PFS), locoregional control (LRC) and overall survival (OS) were estimated by Kaplan–Meier method. Hazard ratios were estimated by Cox proportional hazard models.Results Baseline characteristics of the patients were balanced between two treatment groups (CRT vs NCRT) and were representative of the trial cohort. The median follow-up was of 39.13 months. Low HIF1α was associated with better PFS [HR (95% CI) = 0.62 (0.42–0.93)], LRC [HR (95% CI) = 0.56 (0.37–0.86)] and OS [HR (95% CI) = 0.63 (0.43–0.93)] in the CRT group. Multivariable analysis revealed HIF1α as an independent negative prognostic biomarker. For patients with high HIF1α, NCRT significantly improved the outcomes [PFS:HR (95% CI) = 0.55 (0.37–0.82), LRC:HR (95% CI) = 0.55 (0.36–0.85) and OS:HR (95% CI) = 0.54 (0.36–0.81)] compared to CRT. While in patients with low HIF1α, no difference in the clinical outcomes was observed between treatments. Interaction test suggested a predictive value of HIF1α for OS (P = 0.008).Conclusions High HIF1α expression is a predictor of poor clinical response to CRT in HPV-negative LA-HNSCC patients. These patients with high HIF1α significantly benefited with the addition of nimotuzumab to CRT.Clinical trial registration Registered with the Clinical Trial Registry of India (Trial registration identifier—CTRI/2014/09/004980).Subject terms: Tumour biomarkers, Head and neck cancer, Tumour biomarkers, Head and neck cancer, Predictive markers 相似文献
2.
3.
4.
5.
Surender Kumar Yachha Rakesh Aggarwal S Srinivas Anshu Srivastava Sanjay K Somani Srivenu Itha 《Indian journal of gastroenterology》2006,25(3):132-135
BACKGROUND: We prospectively evaluated the usefulness of IgA tissue transglutaminase antibodies (IgA tTG) in the initial diagnosis of celiac disease (CD) and compared its diagnostic potential with that of IgA anti-endomysial antibodies (IgA EMA) and anti-IgA and IgG gliadin antibodies (AGA and AGG, respectively). METHODS: Sera of 23 untreated children fulfilling the revised ESPGHAN criteria for diagnosis of CD (Group I; mean age 10.8 y); 19 disease controls (Group II; mean age 8.5 y) presenting with chronic diarrhea, short stature or both; and 22 healthy children (Group III; mean age 8.8 y) were studied. These were tested in a blinded manner for AGA, AGG, IgA tTG (guinea pig as antigen) and IgA EMA. RESULTS: In Group I, IgA EMA was positive in 19, IgA tTG in 17, AGA in 14 and AGG in 17 patients. In Group II, these tests were positive in 1, 0, 2 and 14 patients, respectively and in Group III, in 0, 0, 0 and 1 child, respectively. Analyzing data from Group I and II, IgA EMA, IgA tTG, AGA and AGG had sensitivity rates of 83%, 74%, 61% and 74%, respectively; the specificity rates were 95%, 100%, 89% and 26%; positive predictive values were 95%, 100%, 88% and 55% and negative predictive values were 82%, 74%, 65% and 45%, respectively. CONCLUSION: IgA tTG is useful for the diagnosis of CD, with sensitivity and specificity rates comparable to those of EMA and this test is well suited for use in tropical countries like India. 相似文献
6.
There has been a remarkable change in the scenario of therapeutic apheresis in the last 14 years in India. The crude method of manual removal of blood followed by separation of plasma by gravity, keeping it in the bottle for a long time, has now been totally replaced by plasmapheresis, centrifugation, membrane filtration, and immunoadsorption techniques. The indications for use have also changed from a list of limited indications in the beginning to include all immune complex disorders. The clinical beneficiaries have also increased from blood bankers to nephrologists and immunologists in addition to oncologists. Efforts are now underway with the help of the Indian Society for Apheresis (founded in 1985) to popularize the newer methods of cryofiltration, photopheresis and heparin extracorporeal low-density lipoprotein (HELP) and DALI apheresis systems besides the specialized techniques of immunoadsorption using filters, columns, or ligands. This is suggestive of a positive trend for the treatment of immune complex disorders. 相似文献
7.
Pankaj Hari Anand Srivastava Arun Kumar Gupta Rajendra N. Srivastava 《Pediatric nephrology (Berlin, Germany)》1997,11(4):497-498
Acute renal failure (ARF) developed in a 7-week-old infant due to bilateral candidal bezoars (fungal balls) causing obstruction
at the pelviureteric junction. The baby was born at term with an appropriate birthweight, and had been treated with broad-spectrum
antibiotics for respiratory distress and septicemia during the 1st week of life. Recovery from ARF followed renal decompression
with bilateral nephrostomy tube placement and parenteral administration of amphotericin B and 5-flucytosine.
Received August 21, 1996; received in revised form and accepted January 3, 1997 相似文献
8.
Of 132 children with bladder stones seen in 1 year, 94% were boys and 73% were aged between 1 and 5 years. Significant malnutrition and evidence of vitamin deficiency were absent. Wheat bread was the dietary staple, while the intake of milk and dairy products, eggs and meat was very low. Analysis of 29 stones showed them to consist mainly of calcium oxalate and uric acid, with small amounts of calcium phosphate and magnesium ammonium phosphate in some cases. The composition of the surface and central parts of the stones, examined in 20 cases, was usually different. The nucleus was formed almost entirely of calcium oxalate and uric acid in four and three cases respectively, whereas the surface layers were composed of other ingredients. In another case the nucleus was composed entirely of xanthine, which indicated a diagnosis of xanthinuria. 相似文献
9.
10.