全文获取类型
收费全文 | 1906篇 |
免费 | 148篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 70篇 |
妇产科学 | 20篇 |
基础医学 | 233篇 |
口腔科学 | 59篇 |
临床医学 | 197篇 |
内科学 | 339篇 |
皮肤病学 | 53篇 |
神经病学 | 110篇 |
特种医学 | 160篇 |
外科学 | 331篇 |
综合类 | 42篇 |
一般理论 | 2篇 |
预防医学 | 135篇 |
眼科学 | 99篇 |
药学 | 83篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 106篇 |
出版年
2021年 | 29篇 |
2020年 | 17篇 |
2019年 | 26篇 |
2018年 | 37篇 |
2017年 | 31篇 |
2016年 | 33篇 |
2015年 | 35篇 |
2014年 | 37篇 |
2013年 | 43篇 |
2012年 | 96篇 |
2011年 | 104篇 |
2010年 | 58篇 |
2009年 | 46篇 |
2008年 | 86篇 |
2007年 | 73篇 |
2006年 | 89篇 |
2005年 | 71篇 |
2004年 | 53篇 |
2003年 | 61篇 |
2002年 | 54篇 |
2001年 | 45篇 |
2000年 | 46篇 |
1999年 | 59篇 |
1998年 | 28篇 |
1997年 | 33篇 |
1996年 | 36篇 |
1995年 | 24篇 |
1994年 | 19篇 |
1993年 | 18篇 |
1992年 | 43篇 |
1991年 | 36篇 |
1990年 | 35篇 |
1989年 | 42篇 |
1988年 | 43篇 |
1987年 | 36篇 |
1986年 | 29篇 |
1985年 | 27篇 |
1984年 | 26篇 |
1983年 | 14篇 |
1982年 | 17篇 |
1981年 | 17篇 |
1980年 | 17篇 |
1979年 | 28篇 |
1978年 | 31篇 |
1975年 | 13篇 |
1974年 | 23篇 |
1973年 | 15篇 |
1969年 | 17篇 |
1968年 | 20篇 |
1967年 | 12篇 |
排序方式: 共有2058条查询结果,搜索用时 421 毫秒
71.
M A Maloney R A Lamela M J Banda H M Patt 《Proceedings of the National Academy of Sciences of the United States of America》1982,79(3):840-844
To examine the hypothesis that bone marrow consists of discrete stem cell regulatory volumes or domains, we studied spleen colony-forming unit (CFU-S) population growth kinetics in unirradiated WBB6F1-W/Wv mice receiving various doses of +/+ bone marrow cells. Assay of femoral marrow CFU-S content in the eight recipient dose groups revealed a family of growth curves having an initial dose-independent exponential phase and a subsequent dose-dependent deceleration phase. CFU-S content at the growth transition (inflection point) was not a simple linear function of inoculum dose but was shown rather to reflect a random distribution of initially seeded donor CFU-S in discrete volumes of recipient bone marrow. The inoculum dose resulting in a mean of 1 CFU-S per bone marrow sampling unit was estimated to be 17 x 10(6) bone marrow cells, corresponding to a total marrow uptake of approximately 5100 CFU-S (based on a seeding efficiency factor of 10%). If we assume single-hit kinetics, it follows that the recipient W/Wv bone marrow may contain approximately 5100 domains in which stem cell proliferation is geared to the density of the stem cell population. When the various inocula were corrected for multiple seeding in a given domain, the mean inflection point per domain was similar and indicative of five or so divisions before departure from exponential growth at approximately 20% of final CFU-S content 8 days after bone marrow injection. The partitioning of bone marrow into highly localized functional units is consistent with the putative regulatory role of short-range interactions between stem cells and essential stromal elements. 相似文献
72.
Brian Kornblit David G. Maloney Barry E. Storer Michael B. Maris Lars Vindel?v Parameswaran Hari Amelia A. Langston Michael A. Pulsipher Wolfgang A. Bethge Thomas R. Chauncey Thoralf Lange Finn B. Petersen Kai Hübel Ann E. Woolfrey Mary E.D. Flowers Rainer Storb Brenda M. Sandmaier 《Haematologica》2014,99(10):1624-1631
The study is a randomized phase II trial investigating graft-versus-host disease prophylaxis after non-myeloablative (90 mg/m2 fludarabine and 2 Gy total body irradiation) human leukocyte antigen matched unrelated donor transplantation. Patients were randomized as follows: arm 1 – tacrolimus 180 days and mycophenolate mofetil 95 days (n=69); arm 2 – tacrolimus 150 days and mycophenolate mofetil 180 days (n=71); arm 3 – tacrolimus 150 days, mycophenolate mofetil 180 days and sirolimus 80 days (n=68). All patients had sustained engraftment. Grade II-IV acute graft-versus-host disease rates in the 3 arms were 64%, 48% and 47% at Day 150, respectively (arm 3 vs. arm 1 (hazard ratio 0.62; P=0.04). Owing to the decreased incidence of acute graft-versus-host disease, systemic steroid use was lower at Day 150 in arm 3 (32% vs. 55% in arm 1 and 49% in arm 2; overall P=0.009 by hazard ratio analysis). The Day 150 incidence of cytomegalovirus reactivation was lower in arm 3 (arm 1, 54%; arm 2, 47%; arm 3, 22%; overall P=0.002 by hazard ratio analysis). Non-relapse mortality was comparable in the three arms at two years (arm 1, 26%; arm 2, 23%; arm 3, 18%). Toxicity rates and other outcome measures were similar between the three arms. The addition of sirolimus to tacrolimus and mycophenolate mofetil is safe and associated with lower incidence of acute graft-versus-host disease and cytomegalovirus reactivation. (clinicaltrials.gov identifier: 00105001). 相似文献
73.
Mathew J. Bryant Simon N. Black Helen Blade Robert Docherty Andrew G.P. Maloney Stefan C. Taylor 《Journal of pharmaceutical sciences》2019,108(5):1655-1662
We report the generation and statistical analysis of the CSD drug subset: a subset of the Cambridge Structural Database (CSD) consisting of every published small-molecule crystal structure containing an approved drug molecule. By making use of InChI matching, a CSD Python API workflow to link CSD entries to the online database Drugbank.ca has been produced. This has resulted in a subset of 8632 crystal structures, representing all published solid forms of 785 unique drug molecules. We hope that this new resource will lead to improvements in targeted cheminformatics and statistical model building in a pharmaceutical setting. In addition to this, as part of the Advanced Digital Design of Pharmaceutical Therapeutics collaboration between academia and industry, we have been given the unique opportunity to run comparative analysis on the internal crystal structure databases of AstraZeneca and Pfizer, alongside comparison to the CSD as a whole. 相似文献
74.
Lesley A. Mathews Griner Rajarshi Guha Paul Shinn Ryan M. Young Jonathan M. Keller Dongbo Liu Ian S. Goldlust Adam Yasgar Crystal McKnight Matthew B. Boxer Damien Y. Duveau Jian-Kang Jiang Sam Michael Tim Mierzwa Wenwei Huang Martin J. Walsh Bryan T. Mott Paresma Patel William Leister David J. Maloney Christopher A. Leclair Ganesha Rai Ajit Jadhav Brian D. Peyser Christopher P. Austin Scott E. Martin Anton Simeonov Marc Ferrer Louis M. Staudt Craig J. Thomas 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(6):2349-2354
75.
Elizabeth F. Krakow Boglarka Gyurkocza Barry E. Storer Thomas R. Chauncey Jeannine S. McCune Jerald P. Radich Michelle E. Bouvier Elihu H. Estey Rainer Storb David G Maloney Brenda M. Sandmaier 《American journal of hematology》2020,95(1):48-56
Clofarabine is an immunosuppressive purine nucleoside analog that may have better anti-leukemic activity than fludarabine. We performed a prospective phase I/II multisite trial of clofarabine with 2 Gy total body irradiation as non-myeloablative conditioning for allogeneic hematopoietic cell transplantation in adults with acute myeloid leukemia who were unfit for more intense regimens. Our main objective was to improve the 6-month relapse rate following non-myeloablative conditioning, while maintaining historic rates of non-relapse mortality (NRM) and engraftment. Forty-four patients, 53 to 74 (median: 69) years, were treated with clofarabine at 150 to 250 mg/m2, of whom 36 were treated at the maximum protocol-specified dose. One patient developed multifactorial acute kidney injury and another developed multiorgan failure, but no other grade 3 to 5 non-hematologic toxicities were observed. All patients fully engrafted. The 6-month relapse rate was 16% (95% CI, 5%-27%) among all patients and 14% (95% CI, 3%-26%) among high-risk patients treated at the maximum dose, meeting the pre-specified primary efficacy endpoint. Overall survival was 55% (95% CI, 40%-70%) and leukemia-free survival was 52% (95% CI, 37%-67%) at 2 years. Compared to a historical high-risk cohort treated with the combination of fludarabine at 90 mg/m2 and 2 Gy TBI, protocol patients treated with the clofarabine-TBI regimen had lower rates of overall mortality (HR of 0.50, 95% CI, 0.28-0.91), disease progression or death (HR 0.48, 95% CI, 0.27-0.85), and morphologic relapse (HR 0.30, 95% CI, 0.13-0.69), and comparable NRM (HR 0.85, 95% CI 0.36-2.00). The combination of clofarabine with TBI warrants further investigation in patients with high-risk AML. 相似文献
76.
Typical methods for the identification of Burkholderia pseudomallei colonies produce results in 18 h. The Remel RapID NF Plus kit produces results in 4 h. We used the kit for 190 stored B. pseudomallei isolates and correctly identified 189 of them. This kit produces consistent results for known B. pseudomallei isolates. 相似文献
77.
78.
79.
Refractory pityriasis rubra pilaris treated with etanercept,adalimumab, or ustekinumab: A retrospective investigation
下载免费PDF全文
![点击此处可从《Dermatologic therapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Pityriasis rubra pilaris (PRP) is a rare, difficult to treat papulosquamous disorder that responds variably to retinoids and immunosuppression. Successful use of biologics for treating PRP has been described in the literature by case reports and a limited number of case series. To provide additional data, we retrospectively analyzed cases of PRP treated with biologics at our institution. We identified seven patients with a clear diagnosis of PRP treated with adalimumab, etanercept, and/or ustekinumab at our institution from January 1, 2014 to April 1, 2017. Six of seven patients had type I, adult acquired PRP, and one had type V atypical juvenile PRP. In response to tumor necrosis factor (TNF)‐α inhibition, two patients had marked responses (>75% improvement in involved body surface area), while three patients failed to show any improvement on a TNF‐α inhibitor. In two cases of PRP refractory to TNF‐α inhibition, ustekinumab resulted in a partial response (<75% improvement) in one patient and no response in the other. Compared to other published data, our cohort was substantially more resistant to treatment with biologics, a finding which may provide valuable perspective for dermatologists managing refractory PRP in the future. 相似文献
80.
Robert L. Barrack C. Lowry Barnes R. Stephen J. Burnett Derek Miller John C. Clohisy William J. Maloney 《The Journal of arthroplasty》2009
A consecutive series of revision total knee arthroplasty (TKA) performed at 3 centers by 5 surgeons for a 3-year period was reviewed. Revisions performed for infection and rerevisions were excluded. Review of clinical and radiographic data determined incision type, sex, age, time to revision, and primary diagnosis at time of revision. Two-hundred thirty-seven first-time revision TKAs were performed, of which 44 (18.6%) had been a minimal incision surgery (MIS) primary TKA and 193 (81.4%) had been a standard primary TKA. Patients with MIS were younger (62.1 vs 66.2 years, P = .02). Most striking was the difference in time to revision, which was significantly shorter for the MIS group (14.8 vs 80 months, P < .001). Minimal incision surgery TKA accounted for a substantial percentage of revision TKA in recent years at these centers. The high prevalence of MIS failures occurring within 24 months is disturbing and warrants further investigation. 相似文献