全文获取类型
收费全文 | 84篇 |
免费 | 1篇 |
专业分类
儿科学 | 12篇 |
妇产科学 | 9篇 |
基础医学 | 9篇 |
口腔科学 | 1篇 |
临床医学 | 2篇 |
内科学 | 24篇 |
神经病学 | 5篇 |
特种医学 | 2篇 |
外科学 | 8篇 |
综合类 | 2篇 |
眼科学 | 2篇 |
药学 | 4篇 |
肿瘤学 | 5篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2021年 | 2篇 |
2019年 | 1篇 |
2017年 | 3篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 6篇 |
2013年 | 2篇 |
2012年 | 8篇 |
2011年 | 9篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 2篇 |
2007年 | 7篇 |
2006年 | 7篇 |
2004年 | 5篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有85条查询结果,搜索用时 312 毫秒
21.
Safety and clinical findings of BiPAP utilization in children 20 kg or less for asthma exacerbations
Williams AM Abramo TJ Shah MV Miller RA Burney-Jones C Rooks S Estrada C Arnold DH 《Intensive care medicine》2011,37(8):1338-1343
Purpose
To investigate safety and clinical findings of bilevel positive airway pressure (BiPAP) utilization in children 20 kg or less for asthma exacerbations. 相似文献22.
Abhijit A. Patil Parag Sayal Marie-Lise Depondt Ryan D. Beveridge Anthony Roylance Deepti H. Kriplani Katie N. Myers Angela Cox David Jellinek Malee Fernando Thomas A. Carroll Spencer J. Collis 《Oncotarget》2014,5(15):6414-6424
Brain tumours kill more children and adults under 40 than any other cancer. Around half of primary brain tumours are glioblastoma multiforme (GBMs) where treatment remains a significant challenge. GBM survival rates have improved little over the last 40 years, thus highlighting an unmet need for the identification/development of novel therapeutic targets and agents to improve GBM treatment. Using archived and fresh glioma tissue, we show that in contrast to normal brain or benign schwannomas GBMs exhibit re-expression of FANCD2, a key protein of the Fanconi Anaemia (FA) DNA repair pathway, and possess an active FA pathway. Importantly, FANCD2 expression levels are strongly associated with tumour grade, revealing a potential exploitable therapeutic window to allow inhibition of the FA pathway in tumour cells, whilst sparing normal brain tissue. Using several small molecule inhibitors of the FA pathway in combination with isogenic FA-proficient/deficient glioma cell lines as well as primary GBM cultures, we demonstrate that inhibition of the FA pathway sensitises gliomas to the chemotherapeutic agents Temozolomide and Carmustine. Our findings therefore provide a strong rationale for the development of novel and potent inhibitors of the FA pathway to improve the treatment of GBMs, which may ultimately impact on patient outcome. 相似文献
23.
24.
25.
26.
Weerapong Juntachai Aksarakorn Kummasook Malee Mekaprateep Susumu Kajiwara 《Mycoses》2014,57(3):163-168
Malassezia species are part of the normal skin flora and are associated with a number of human and animal skin diseases. However, the mechanisms that mediate infection and host–fungal interactions are poorly understood. The haemolytic activity of several microorganisms is considered a factor that contributes to pathogenicity of the organism to humans and animals. This virulence factor was previously identified in several pathogenic fungi that cause systemic mycoses, such as Aspergillus and Candida. In this study, the haemolytic activity of six major Malassezia species, including M. furfur, M. globosa, M. pachydermatis, M. restricta, M. slooffiae and M. sympodialis, was investigated. The haemolytic activity of these species was tested on tryptone soya agar with 5% sheep blood. All the examined Malassezia species produced a halo zone of complete haemolysis. A quantitative analysis of the haemolytic activity was performed by incubating sheep erythrocytes with the extraction from culture of each Malassezia species. Interestingly, M. globosa and M. restricta showed significantly high haemolytic activity compared with the other Malassezia species. In addition, M. globosa also exhibited stable haemolytic activity after treatment at 100 °C and in the presence of some proteases, indicating that this haemolytic factor is different from those of other fungi. 相似文献
27.
28.
29.
Megan M. Herting Kristina A. Uban Paige L. Williams Prapti Gautam Yanling Huo Kathleen Malee Ram Yogev John Csernansky Lei Wang Sharon Nichols Russell Van Dyke Elizabeth R. Sowell 《Medicine》2015,94(37)
Youth with perinatally acquired human immunodeficiency virus (PHIV+) survive longer with combination antiretroviral therapy, but remain at risk for poor cognitive outcomes. We evaluated whether markers of HIV disease severity relate to default mode resting-state functional connectivity in PHIV+ youth.We conducted resting-state functional neuroimaging and cognitive testing in a subset of 40 PHIV+ youth recruited from a single study site of the Adolescent Master Protocol study conducted by the Pediatric HIV/AIDS Cohort Study (PHACS) network. Current and past HIV disease severity measures (nadir CD4 lymphocyte percentages and peak HIV RNA plasma levels) were obtained from medical charts.We evaluated associations of both HIV disease severity measures and cognitive functioning with between- and within- default mode network (DMN) connectivity using Analysis of Functional NeuroImaging multiple regression analyses, controlling for multiple comparisons.Of the 40 youth, 31 (mean age = 16.5 years) with minimal motion during scans were included. We observed global alterations in DMN within- and between-network connectivity, with significant associations between disease severity and DMN BOLD correlations. Furthermore, patterns of connectivity with the posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) that varied as a function of peak HIV RNA were found to predict processing speed ability.Alterations in within- and between-network DMN connectivity in PHIV+ youth may reflect global reorganization of the DMN; this could lead to compensatory alterations in both the within- and between-connectivity of large-scale networks, which may ultimately relate to known cognitive processing difficulties in PHIV+ youth. 相似文献