全文获取类型
收费全文 | 12375篇 |
免费 | 1355篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 91篇 |
儿科学 | 458篇 |
妇产科学 | 315篇 |
基础医学 | 1904篇 |
口腔科学 | 202篇 |
临床医学 | 1338篇 |
内科学 | 2506篇 |
皮肤病学 | 139篇 |
神经病学 | 1044篇 |
特种医学 | 319篇 |
外科学 | 1426篇 |
综合类 | 269篇 |
一般理论 | 14篇 |
预防医学 | 1490篇 |
眼科学 | 172篇 |
药学 | 1073篇 |
中国医学 | 23篇 |
肿瘤学 | 967篇 |
出版年
2021年 | 175篇 |
2020年 | 125篇 |
2019年 | 142篇 |
2018年 | 222篇 |
2017年 | 151篇 |
2016年 | 207篇 |
2015年 | 205篇 |
2014年 | 307篇 |
2013年 | 496篇 |
2012年 | 658篇 |
2011年 | 707篇 |
2010年 | 359篇 |
2009年 | 374篇 |
2008年 | 643篇 |
2007年 | 713篇 |
2006年 | 657篇 |
2005年 | 654篇 |
2004年 | 657篇 |
2003年 | 600篇 |
2002年 | 616篇 |
2001年 | 249篇 |
2000年 | 252篇 |
1999年 | 233篇 |
1998年 | 165篇 |
1997年 | 161篇 |
1996年 | 159篇 |
1995年 | 147篇 |
1994年 | 144篇 |
1993年 | 144篇 |
1992年 | 216篇 |
1991年 | 222篇 |
1990年 | 217篇 |
1989年 | 167篇 |
1988年 | 190篇 |
1987年 | 179篇 |
1986年 | 139篇 |
1985年 | 179篇 |
1984年 | 137篇 |
1983年 | 132篇 |
1982年 | 108篇 |
1981年 | 93篇 |
1980年 | 96篇 |
1979年 | 111篇 |
1978年 | 93篇 |
1977年 | 69篇 |
1976年 | 66篇 |
1975年 | 81篇 |
1974年 | 89篇 |
1973年 | 81篇 |
1972年 | 75篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
A technique is described in which superficial musculoaponeurotic system (SMAS) is plicated from the deep temporal fascia
above the zygoma to the level of the earlobe. This procedure requires only an extended preauricular incision. The neck is
dealt with by liposuction. This technique is ideally suited to the younger patient requesting facelift and is based on a sound
understanding of the anatomy of SMAS. The outcome of 35 patients who underwent this procedure during a 3.5-year period are
described. There were no cases of facial nerve paresis or hair loss. There were no cases of skin necrosis but two patients
developed small hematomas and one patient complained of a stretched preauricular scar. The mini facelift leads to a satisfactory
result in the younger patient requesting rhytidectomy. The technique is simple and safe and can easily be performed on an
ambulatory basis. Complications are uncommon and of a minor nature. 相似文献
42.
Mo Therese Hannah Ellen R. Gritz David K. Wellisch Pat Fobair Richard T. Hoppe Joan R. Bloom Guo-Wen Sun Anna Varghese Malcolm D. Cosgrove David Spiegel 《Psycho-oncology》1992,1(2):89-103
This study compares the effects of the cancer experience on various aspects of marital and sexual functioning (e.g., communication, emotional support, body image, sexual satisfaction and frequency) for two groups of long-term cancer survivors (testicular cancer and Hodgkin's disease) and their spouses. Comparisons between the two patient groups showed significantly more survivors of Hodgkin's disease than testicular cancer reporting the emergence of special issues and changes in the marital relationship. No differences emerged between the spouse groups on sexual functioning variables; however, spouses of survivors of Hodgkin's disease were more likely than spouses of survivors of testicular cancer to report the development of special issues and communication difficulties. A substantial proportion of both survivor groups disclosed negative changes in body image and sexual frequency. Majorities of both survivors and spouses acknowledged that the illness had drawn them closer together. When representative marital/sexual functioning variables were used to predict Family Environment Scale (FES) scores for survivors and for spouses, changes in the spouse's importance, influence of the illness on the relationship, and changes in sexual frequency emerged as significant predictors. The clinical significance of long-term changes in marital and sexual functioning for the couple and the need for therapeutic interventions are discussed. 相似文献
43.
Objective morphological assessment of macular hole surgery by scanning laser tomography 总被引:2,自引:2,他引:0 下载免费PDF全文
C. Hudson S. Charles J. Flanagan A. Brahma G. Turner D. McLeod 《The British journal of ophthalmology》1997,81(2):107-116
AIM—To assess the morphological change in retinal topography using a scanning laser tomographer following macular hole surgery. To compare the results of scanning laser tomography with clinical evaluation and visual function assessment.
METHODS—The sample for this pilot study comprised four eyes exhibiting different stages of macular hole formation preoperatively. Subjects were assessed preoperatively and at 1 and 3 months postoperatively. Each assessment included visual acuity, letter contrast sensitivity, clinical examination (including automated static perimetry), and scanning laser tomography. The Heidelberg retina tomograph (HRT) was used to acquire digitised scanning laser tomography images of the macula (10° and 20° fields). Surgery essentially comprised vitrectomy, peeling of the posterior hyaloid face, if still attached, and intraocular gas tamponade. The magnitude and significance of topographic change were determined postoperatively using the HRT topographic difference facility.
RESULTS—Topographic difference analysis of the right and left eyes of case 1 showed a significant reduction in the height of the retina postoperatively. Topographic difference analysis of case 2 showed no significant change in topography. Topographic difference analysis of case 3 showed a significant increase in the height of the retina postoperatively. Scanning laser tomography agreed with clinical assessment based upon fundus biomicroscopy in three of the four eyes studied; the postoperative closure of the stage 2 macular hole (as noted by clinical assessment) proved to be too small to reach statistical significance. Scanning laser tomography agreed with the assessment of visual function in two eyes; the agreement between scanning laser tomography and visual function depends, in part, on the stage of development of the macular hole.
CONCLUSION—Scanning laser tomography provides an objective evaluation of the outcome of macular hole surgery. Studies employing larger sample sizes are required to fully determine the clinical worth of the technique.
相似文献
METHODS—The sample for this pilot study comprised four eyes exhibiting different stages of macular hole formation preoperatively. Subjects were assessed preoperatively and at 1 and 3 months postoperatively. Each assessment included visual acuity, letter contrast sensitivity, clinical examination (including automated static perimetry), and scanning laser tomography. The Heidelberg retina tomograph (HRT) was used to acquire digitised scanning laser tomography images of the macula (10° and 20° fields). Surgery essentially comprised vitrectomy, peeling of the posterior hyaloid face, if still attached, and intraocular gas tamponade. The magnitude and significance of topographic change were determined postoperatively using the HRT topographic difference facility.
RESULTS—Topographic difference analysis of the right and left eyes of case 1 showed a significant reduction in the height of the retina postoperatively. Topographic difference analysis of case 2 showed no significant change in topography. Topographic difference analysis of case 3 showed a significant increase in the height of the retina postoperatively. Scanning laser tomography agreed with clinical assessment based upon fundus biomicroscopy in three of the four eyes studied; the postoperative closure of the stage 2 macular hole (as noted by clinical assessment) proved to be too small to reach statistical significance. Scanning laser tomography agreed with the assessment of visual function in two eyes; the agreement between scanning laser tomography and visual function depends, in part, on the stage of development of the macular hole.
CONCLUSION—Scanning laser tomography provides an objective evaluation of the outcome of macular hole surgery. Studies employing larger sample sizes are required to fully determine the clinical worth of the technique.
相似文献
44.
David S. Browne FRCOG FRACOG Malcolm I. Frazer MD MRCOG 《The Australian & New Zealand journal of obstetrics & gynaecology》1991,31(2):148-152
This paper summarizes the results obtained in 279 vaginal hysterectomies performed in the 5 years 1985-1989 in the public and private practices of a single gynaecologist. It is suggested that it is feasible and safe to perform a hysterectomy vaginally in preference to the abdominal route in the majority of women, even in the absence of uterine descent. It is essential that registrars in training continue to be thoroughly versed in the techniques of vaginal surgery if such techniques are not to be forgotten. 相似文献
45.
46.
Malcolm E. Richardson Samuel Menahem James L. Wilkinson 《International journal of cardiology》1991,30(3):351-353
In this report, we give details of two families in which fixed subaortic stenosis was found in more than one member. It is rare for this entity to show familial incidence. 相似文献
47.
48.
Important risk factors of allograft survival in cadaveric renal transplantation. A study of 426 patients. 总被引:1,自引:1,他引:0 下载免费PDF全文
A G Diethelm E H Blackstone D C Naftel S L Hudson W H Barber M H Deierhoi B O Barger J J Curtis R G Luke 《Annals of surgery》1988,207(5):538-548
Multiple risk factors contribute to the allograft survival of patients who have cadaveric renal transplantation. A retrospective review of 19 such factors in 426 patients identified race, DR match, B + DR match, number of transplants, and preservation time to have a significant influence. The parametric analysis confirmed the effect to be primarily in the early phase, i.e., first 6 months. All patients received cyclosporine with other methods of immunosuppression resulting in an overall 1-year graft survival rate of 66%. The overall 1-year graft survival rate in the white race was 73% and in the black race was 57% (p = 0.002). Allograft survival and DR match showed white recipients with a 1 DR match to have 75% survival at 1 year compared with 57% in the black patient (p = 0.009). If HLA B + DR match was considered, the white recipient allograft survival increased to 76%, 84%, and 88% for 1, 2, and 3 match kidneys by parametric analysis. Patients receiving first grafts had better graft survival (68%) than those undergoing retransplantation (58%) (p = 0.05). Organ preservation less than 12 hours influenced allograft survival with a 78% 1-year survival rate compared with 63% for kidneys with 12-18 hours of preservation. Despite the benefits of B + DR typing, short preservation time, and first transplants to the white recipient, the allograft survival in the black recipient remained uninfluenced by these parameters. 相似文献
49.
Barry D Anderson Peter C Adamson Susan L Weiner Mary S McCabe Malcolm A Smith 《Journal of clinical oncology》2004,22(23):4846-4850
Federal regulations prescribe distinct protections for children participating in research studies. Procedures for collecting tissue specimens from children solely for research purposes must pose no more than a minor increase over minimum risk, thereby limiting the approvable correlative biologic studies to evaluate molecularly targeted agents in children with cancer. Ethical issues arise when approvable correlative studies are a mandatory component of an early-phase pediatric clinical trial of new anticancer agents. The National Cancer Institute Cancer Therapy Evaluation Program sponsored a workshop in 2002 to discuss tissue collection for correlative biologic studies in early-phase childhood cancer clinical studies of molecularly targeted agents. Workshop participants recommended the following: (1) tissue specimens for correlative studies should provide vital clinical and scientific results to qualify for early-phase pediatric study consideration; (2) parents should receive a realistic appraisal of the risks, requirements, and potential for benefit of phase I protocol participation; (3) investigators should clearly distinguish clinically necessary procedures from research procedures of no benefit to the child to improve correlative study informed consent; and (4) participation in correlative research studies included in clinical trials generally should be voluntary. The need to acquire important biologic data regarding new molecular agents will challenge the ingenuity of pediatric cancer researchers, necessitating the application of highly sensitive laboratory assay methods, new imaging procedures, and preclinical models of childhood cancer. Such innovative methods can allow necessary scientific information to be obtained while simultaneously respecting the protections appropriately afforded to children participating in research studies and minimizing the burden of research participation for children with cancer and their families. 相似文献
50.
We have reported a rare case of acute large bowel obstruction complicating acute pancreatitis. The diagnosis of pancreatitis is often initially not considered in such patients, and is established only at laparotomy. The splenic flexure is the most common site of large bowel involvement. A proximal defunctioning colostomy is the preferred primary management. 相似文献