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131.
Nierman WC Feldblyum TV Laub MT Paulsen IT Nelson KE Eisen JA Heidelberg JF Alley MR Ohta N Maddock JR Potocka I Nelson WC Newton A Stephens C Phadke ND Ely B DeBoy RT Dodson RJ Durkin AS Gwinn ML Haft DH Kolonay JF Smit J Craven MB Khouri H Shetty J Berry K Utterback T Tran K Wolf A Vamathevan J Ermolaeva M White O Salzberg SL Venter JC Shapiro L Fraser CM Eisen J 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(7):4136-4141
132.
After myocardial infarction there is an acute deterioration of the flow properties of blood. The present study was designed to test whether the abnormality persists. Blood and plasma viscosity, red cell aggregation and deformability, haematocrit, erythrocyte sedimentation rate, white cell count, cholesterol, and triglycerides were measured in 51 patients who had had a myocardial infarction 5.4 (mean) years before. Results in patients and controls were compared and matched pairs with identical cardiovascular risk factors were also selected. Blood viscosity and red cell aggregation were increased and red cell deformability was decreased in the 51 patients. The abnormalities were independent of the interval since infarction and persisted for years. The rheological abnormalities present after myocardial infarction are at least partly independent of the acute event and acute phase reactions. They contribute to the reduced perfusion of the microcirculation of the heart. 相似文献
133.
Atul Mehta David J. Kuter Sam S. Salek Nadia Belmatoug Bruno Bembi Jeremy Bright Stephan vom Dahl Federica Deodato Maja Di Rocco Ozlem Göker‐Alpan Derralynn A. Hughes Elena A. Lukina Maciej Machaczka Eugen Mengel Aabha Nagral Kimitoshi Nakamura Aya Narita Beatriz Oliveri Gregory Pastores Jordi Pérez‐López Uma Ramaswami Ida V. Schwartz Jeff Szer Neal J. Weinreb Ari Zimran 《Internal medicine journal》2019,49(5):578-591
134.
Involvement of a chloroplast HSP70 heat shock protein in the integration of a protein (light-harvesting complex protein precursor) into the thylakoid membrane
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Yalovsky S Paulsen H Michaeli D Chitnis PR Nechushtai R 《Proceedings of the National Academy of Sciences of the United States of America》1992,89(12):5616-5619
Molecular chaperones, including those belonging to the 70-kDa family of heat shock proteins (HSP70), assist both the translocation of proteins across membranes and their assembly into oligomeric complexes. We purified a chloroplast HSP70 (ct-HSP70) and demonstrated that it plays a major role in the insertion of the precursor of the major light-harvesting complex of photosystem II (pLHCP; an integral membrane protein) into the thylakoids (the inner membranes of the chloroplast). Addition of the purified ct-HSP70 is necessary for efficient insertion of pLHCP into isolated thylakoid membranes. This activity of the purified ct-HSP70 is similar to that previously reported for the total stromal extract. When the chloroplast stromal extract is depleted of HSP70, a correlative reduction in the insertion activity of pLHCP is observed. The interaction between the ct-HSP70 and pLHCP involves physical association. The purified HSP70 acts directly on the membrane protein, presumably prevents its refolding, and thereby helps to maintain its competence for insertion into membranes. 相似文献
135.
Maja Derlink Barbara Pipan Petra Pavlovčič Laura E. Jones Vladimir Meglič William O. C. Symondson Meta Virant-Doberlet 《Conservation Genetics Resources》2014,6(4):933-935
Eleven microsatellite markers were developed for the leafhoppers of the genus Aphrodes using shotgun pyrosequencing and will be used to study the genetic diversity, population structure and gene flow within and between species in this genus in order to assess their conservation status. The number of alleles per locus ranged from 3 to 10, while observed and expected heterozygosity values varied from 0.421–1.000 to 0.542–0.876, respectively. Cross-species amplification was successful among the four congeners. 相似文献
136.
137.
Mller Petra Sell Christian Hadrys Thorsten Hedman Johannes Bredemeyer Steffi Laurent Francois-Xavier Roewer Lutz Achtruth Sabrina Sidstedt Maja Sijen Titia Trimborn Marc Weiler Natalie Willuweit Sascha Bastisch Ingo Parson Walther 《International journal of legal medicine》2020,134(1):185-198
International Journal of Legal Medicine - We present results from an inter-laboratory massively parallel sequencing (MPS) study in the framework of the SeqForSTRs project to evaluate forensically... 相似文献
138.
Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis
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Laurent Younes J. Tilak Ratnanather Timothy Brown Elizabeth Aylward Peg Nopoulos Hans Johnson Vincent A. Magnotta Jane S. Paulsen Russell L. Margolis Roger L. Albin Michael I. Miller Christopher A. Ross PREDICT‐HD Investigators Coordinators of the Huntington Study Group 《Human brain mapping》2014,35(3):792-809
Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT‐HD study, we use statistical shape analysis with deformation markers obtained through “Large Deformation Diffeomorphic Metric Mapping” of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico‐basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention. Hum Brain Mapp 35:792–809, 2014. © 2012 Wiley Periodicals, Inc. 相似文献
139.
Anne-Laure Lapeyraque Nastya Kassir Yves Théorêt Maja Krajinovic Marie-José Clermont Catherine Litalien Véronique Phan 《Pediatric nephrology (Berlin, Germany)》2014,29(6):1081-1088
Background
The objectives of this study were to investigate pharmacokinetic and pharmacogenetic parameters during the conversion on a 1:1 (mg:mg) basis from a twice-daily (Prograf) to once-daily (Advagraf) tacrolimus formulation in pediatric kidney transplant recipients.Methods
Twenty-four-hour pharmacokinetic profiles were analyzed before and after conversion in 19 stable renal transplant recipients (age 7–19 years). Tacrolimus pharmacokinetic parameters [area under the concentration-time curve (AUC0–24), minimum whole-blood concentration (Cmin), maximum whole-blood concentration (Cmax), and time to achieve maximum whole-blood concentration (tmax)] were compared between Tac formulations and between CYP3A5 and MDR1 genotypes after dose normalization.Results
Both AUC0–24 and Cmin decreased after conversion (223.3 to 197.5 ng.h/ml and 6.5 to 5.6 ng/ml; p?=?0.03 and 0.01, respectively). However, the ratio of the least square means (LSM) for AUC0–24 was 90.8 %, with 90 % CI limits of 85.3 to 96.7 %, falling within bioequivalence limits. The CYP3A5 genotype influences the dose-normalized Cmin with the twice-daily formulation only.Conclusions
Both tacrolimus formulations are bioequivalent in pediatric renal recipients. However, we observed a decrease in AUC0–24 and Cmin after the conversion, requiring close pharmacokinetic monitoring during the conversion period. 相似文献140.
Nenad Filipović Sonja Grubišić Maja Jovanović Marija Dulović Ivanka Marković Olivera Klisurić Aleksandar Marinković Dragana Mitić Katarina Anđelković Tamara Todorović 《Chemical biology & drug design》2014,84(3):333-341
Novel Pd(II) complex with N‐heteroaromatic Schiff base ligand, derived from 8‐quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL‐60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline‐based ligands reduce the cell numbers in a dose‐dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline‐based complexes is predominantly mediated through the induction of apoptotic cell death in HL‐60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated. 相似文献