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排序方式: 共有1079条查询结果,搜索用时 15 毫秒
31.
Seiichi Shimizu Akihiko Oshita Hirotaka Tashiro Hironobu Amano Tsuyoshi Kobayashi Maiko Tanaka Koji Arihiro Hideki Ohdan 《Surgery today》2013,43(4):418-423
A 76-year-old male was referred for the treatment of liver tumors detected by abdominal computed tomography (CT). Dynamic CT revealed a low-density tumor with an irregularly enhanced rim in the left lateral sector, and a highly enhanced, well-circumscribed tumor in the caudate lobe, accompanied by dilation of the intrahepatic biliary ducts in the left lobe. Preoperative imaging studies led to the diagnosis of double cancers consisting of intrahepatic cholangiocarcinoma and hepatocellular carcinoma (HCC). Left hemihepatectomy with caudate lobectomy was performed. The postoperative course was uneventful. Microscopic evaluation revealed that the tumor in the left lateral sector was adenosquamous carcinoma (ASC), whereas that in the caudate lobe was HCC. This report presents the first case describing the resection of synchronous double cancers of primary hepatic ASC and HCC. 相似文献
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33.
Airi Nakayama Tatsuya Hattori Anna Isobe Shohei Kobayashi Go Suzuki Hidetaka Takigami Maiko Kawaguchi 《Journal of applied toxicology : JAT》2020,40(12):1614-1621
Many chemical substances are detectable in house dust, and they are consequently taken into our bodies via the mouth and nose. Triphenyl phosphate (TPhP), a flame retardant that has an estrogen-like effect in vitro, is present in house dust at high concentrations. Estrogen exposure during development has significant influences on reproductive behavior in rodents, and its effects persist until maturity. In the present study, we investigated the effect of early life exposure to TPhP on the reproductive behavior of female rats. Oral treatment with TPhP (25 or 250 mg/kg), ethinyl estradiol (EE; 15 μg/kg) as a positive control, or sesame oil as a negative control, were given to female rats (from birth to 28 days of age). The 8-week-old rats were bilaterally ovariectomized. At 12–15 weeks of age, the rats were subjected to odor preference and sexual behavior tests. In the odor preference test, the oil group showed significantly higher preference for male odor than female odor, but the low-dose TPhP treatment group lost the preference for male odor, indicating a possible outcome of early life TPhP exposure on sexual recognition. In the sexual behavior test, both the EE and TPhP treatment groups displayed significantly less proceptive behavior. These results suggest that early life exposure to TPhP disturbs the normal sexual behavior of female rats. 相似文献
34.
Zeng Xiangpei Elwick Kyleen Mayes Carrie Takahashi Maiko King Jonathan L. Gangitano David Budowle Bruce Hughes-Stamm Sheree 《International journal of legal medicine》2019,133(1):51-58
International Journal of Legal Medicine - Skeletal remains recovered from missing persons’ cases are often exposed to harsh environmental conditions resulting in the DNA being damaged,... 相似文献
35.
Maiko Kusano Mayumi Yamanaka Kei Zaitsu Hiroshi Nakayama Jun’ichi Nakajima Takako Moriyasu Hitoshi Tsuchihashi Akira Ishii 《Forensic Toxicology》2016,34(2):304-315
Synthetic cannabinoids (SCs) are known to have structural or positional isomers. While regulations on synthetic drugs like synthetic cathinones and SCs have been placed worldwide for the ever-growing variety of new designer drugs, laws may not necessarily be applicable to their isomers. Toxicological differences may also exist among isomers for which most new designer drugs are still uninvestigated; thus, isomer differentiation becomes of forensic importance. The aim of this study was to differentiate the regioisomers of alkyl-substituted naphthoylindole-type SCs JWH-122 and JWH-210. Reference standards of the two drugs and their regioisomers were analyzed by gas chromatography–electron ionization-mass spectrometry (GC–EI-MS) first in full scan mode. Isomers that produced identical EI spectra were further analyzed by GC-tandem mass spectrometry (MS/MS) by selecting appropriate precursor ions. For JWH-210, comparison of the product ion spectra and the relative ion intensity ratios obtained from precursor ions at m/z 312 and 183 enabled differentiation between all seven regioisomers. Complete isomeric differentiation by MS/MS analysis was not attainable for JWH-122; however, combining chromatographic results with MS/MS analysis results enabled differentiation for all isomers. Two basic fragmentation pathways were speculated for both SCs; for JWH-210, fragmentation pathway tendencies differed among the isomers, resulting in their distinguishability. Our results demonstrated that the difference between the methyl (JWH-122) and ethyl (JWH-210) group substituents contributed to fragmentation pathway tendency differences and further distinguishability between the regioisomers. Functional group differences, especially their stereochemistries, were indicated to be critical factors in positional isomer differentiation by GC-MS/MS. 相似文献
36.
Maiko Shikama Nao Sonoda Akiko Morimoto Sayaka Suga Tetsuya Tajima Junji Kozawa Norikazu Maeda Michio Otsuki Taka-Aki Matsuoka Iichiro Shimomura Yuko Ohno 《Journal of diabetes investigation.》2021,12(6):1007-1014
Aims/IntroductionCrossing capillaries in the finger nailfold might potentially be a novel diabetic retinopathy (DR) biomarker that could be assessed non‐invasively in the clinical setting. However, the association between crossing capillaries and DR is controversial. This study aimed to investigate the association between the percentage of crossing capillaries in the finger nailfold and DR in patients with type 2 diabetes mellitus.Materials and MethodsThis cross‐sectional study enrolled 108 type 2 diabetes mellitus patients (aged 40–75 years) who visited the outpatient diabetic clinic at Osaka University Hospital, Osaka, Japan, between May and October 2019. Capillary morphology was assessed using nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. Details of DR and other laboratory data were obtained from medical records. The association between the tertile of the percentage of the crossing capillary and DR was analyzed using multivariable logistic regression.ResultsAfter adjusting for age, sex, diabetes duration, glycated hemoglobin, systolic blood pressure, body mass index, and use of renin–angiotensin system inhibitor and antihyperlipidemic medication, the percentage of crossing capillaries was significantly associated with DR (multivariable‐adjusted odds ratios for increasing tertiles of the percentage of crossing capillary: 1 [reference], 2.05 [95% confidence interval 0.53–7.94], and 4.33 [95% confidence interval 1.16–16.21]; P‐trend = 0.028).ConclusionsA higher percentage of crossing capillaries in the nailfold was associated with a higher risk of DR, independent of traditional risk and inhibiting factors, in patients with type 2 diabetes mellitus. 相似文献
37.
Yasuyuki Fujita Takako Ohmaru Nakanishi Maiko Sugitani Kiyoko Kato 《Ultrasound in medicine & biology》2019,45(1):93-97
Point shear wave elastography is an ultrasonography technique used to evaluate tissue elasticity. We examined whether placental elasticity is useful for predicting the onset of pre-eclampsia. Two hundred twenty-one participants were divided into two groups: one group at low risk (n?=?185) and the other at high risk (n?=?36) for pre-eclampsia. The two groups were compared with respect to shear wave velocity (SWV) of the placenta. Use of SWV as a predictor of pre-eclampsia was also investigated by creating a receiver operating characteristic (ROC) curve. The ROC curve was used to set a cutoff SWV value for predicting pre-eclampsia. The SWV of the high-risk group was significantly higher than that of the low-risk group (p < 0.001). Thirteen participants developed pre-eclampsia after SWV measurements, and the SWVs of these participants were significantly higher than those of participants in who pre-eclampsia did not develop. The cutoff value and area under the ROC curve were 1.188 m/s and 0.9118, respectively. Placental elasticity was significantly increased even before the onset of pre-eclampsia onset and, thus, may be a parameter used to predict the onset of pre-eclampsia. 相似文献
38.
39.
Maiko Kawaguchi Kaori Morohoshi Erina Saita Rie Yanagisawa Gen Watanabe Hirohisa Takano Masatoshi Morita Hideki Imai Kazuyoshi Taya Toshiyuki Himi 《Endocrine》2008,33(3):277-284
Pentachlorophenol (PCP), a component of biocides and a contaminant in diverse tissue samples from humans from various geographic
areas, disrupts regulatory effects of thyroid hormones. Here we examined the effects of developmental exposure of rats to
PCP on various aspects of brain development, male reproductive function, and adrenal function, all of which are under thyroid
hormones regulation. PCP was administered to dams and their offspring via drinking water (6.6 mg l−1) during gestation and lactation. Tissue samples were obtained from dams, 3-week-old weanling pups, and 12-week-old pups.
Gene expressions of thyroid hormone receptor β1 and synapsin I, factors that promote brain growth, was increased in the cerebral cortex of PCP-treated weanling females, whereas plasma
concentrations of total thyroxine were decreased in dams and weanling pups, and plasma thyroid-stimulating hormone concentrations
were higher in PCP-treated weanling males. PCP caused a decrease in plasma corticosterone concentrations in 12-week-old female
rats, but not in male rats or weanling females. PCP-treated male pups had significantly increased testis weight at 12 week
of age. No overt signs of toxicity were noted throughout this study. Our results show that PCP exposure during development
causes thyroid function vulnerability, testicular hypertrophy in adults, and aberrations of brain gene expression. 相似文献
40.
Francesco Vairo Emanuele Nicastri Salma Masauni Yussuf Angela Cannas Silvia Meschi Mwanakheir AA Mahmoud Azza H. Mohamed Paul Mohamed Maiko Pasquale De Nardo Nazario Bevilacqua Concetta Castilletti Antonino Di Caro Vincenzo Racalbuto Giuseppe Ippolito 《Emerging infectious diseases》2014,20(3):465-468
We conducted a seroprevalence survey among 500 healthy adult donors at Zanzibar National Blood Transfusion Services. Dengue virus IgG seroprevalence was 50.6% and independently associated with age and urban residence. These data will aid in building a surveillance, preparedness, and response plan for dengue virus infections in the Zanzibar Archipelago.Key words: dengue, seroprevalence, Zanzibar, viruses, vector-borne infections 相似文献