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101.
102.
Savio George Barreto Satish Pawar Sanket Shah Sanjay Talole Mahesh Goel Shailesh V. Shrikhande 《World journal of surgery》2014,38(2):484-489
Background
Better appreciation of the course and factors that influence incidental gallbladder cancer is needed to develop treatment strategies aimed at improved outcomes. The purpose of this study was to determine pattern of disease recurrence and influencing factors in patients undergoing radical re-resection for incidental gallbladder cancer.Methods
Patients undergoing radical re-resection from February 2003 to May 2010 were analyzed. Influence of variables (lymph node ratio, ASA grade, gender, adjuvant treatment, time interval between cholecystectomy and radical re-resection (in months), and TNM stage) on disease-free survival was assessed.Results
Of 163 patients, 127 (92 female and 35 male patients; median age 50 years) underwent successful radical re-resection. Median duration between two surgeries was 2 months (range 1–10). Twenty-five percent of patients with pT1b disease had lymph node metastases. Two-year disease-free survival rate was 79.6 % (median follow-up, 16 months). On follow-up, 18 of 24 patients developed recurrences at distant sites. Lymph node metastasis was the single variable significantly influencing disease-free survival. Adjusting for disease stage when analyzing time interval between cholecystectomy and radical re-resection on a continuous scale as a prognostic factor for recurrence revealed no significant impact of increasing interval between surgeries (hazard ratio 1.12; 95 % confidence interval 0.95–1.34; p = 0.17).Conclusions
The most important predictor of disease recurrence is lymph node metastases. In patients who undergo curative radical re-resection for incidental gallbladder cancer, recurrent disease is more likely to occur at distant sites. Patients with pT1b disease should be offered radical re-resection with a radical lymphadenectomy. It is not the delay in revision surgery but TNM stage that influences outcomes in incidental gallbladder cancer. 相似文献103.
VGM Naidu Uma Mahesh Bandari Ashwini Kumar Giddam Kuppan Rajendran Dinesh Babu Jian Ding K Suresh Babu B Ramesh Rajeswara Rao Pragada P Gopalakrishnakone 《Asian Pacific journal of tropical medicine》2013,6(5):337-345
ObjectiveTo evaluate the anti-proliferative and apoptogenic activity of ethyl acetate extract from the leaves of Memecylon edule (EtAc-LME) in MKN-74, NUGC gastric cancer cells and non cancerous gastric mucous cells (GES-1), and to explore the mechanism of EtAc-LME induced apoptosis.MethodsThe mechanism of EtAc-LME induced apoptosis was explored by analysing the activation of pro-caspases, PARP cleavage, expression of cytochrome-c (Cyt-c) was determined by western blotting, mRNA expression of Bcl-2, Bax by RT-PCR, loss of mitochondrial potential using DiOC6 dye, annexin binding assay and its influence on cell cycle arrest by flow cytometry.ResultsThe results indicated that EtAc-LME inhibited the gastric cancer cell growth in dose-dependent manner and cytotoxicity was more towards the gastric cancer cells (NUGC and MKN-74) compared to normal gastric cells (GES-1), suggesting more specific cytotoxicity to the malignant cells. Over expression of Cyt-c and subsequent activation of caspases-3 and down regulation of Bcl-2 and loss in mitochondrial potential in EtAc-LME treated MKN-74 and NUGC cells suggested that EtAc-LME induced apoptosis by mitochondrial dependent pathway.ConclusionsThe present findings suggest that ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells emphasizing the importance of this traditional medicine for its potential in the treatment of gastric cancer. 相似文献
104.
105.
Biju Pottakkat Mahesh Sundaram Parvinder Singh 《Clinical journal of gastroenterology》2010,3(6):324-326
Gallstone spillage during laparoscopic cholecystectomy may be a source of significant morbidity. In this report, we describe
the clinical course of a patient who presented with a tender right subcostal swelling. She had had a laparoscopic cholecystectomy
11 years earlier. Imaging revealed a dumbbell-shaped abscess in the perihepatic area with communication into the subcutaneous
tissue with a stone inside the cavity. The patient underwent abscess drainage and the stone was retrieved. During laparoscopic
cholecystectomy, every effort should be made to remove spilled gallstones to prevent further complications but conversion
is not mandatory. 相似文献
106.
Balwinder Singh M.B.B.S. Mahesh Kuruba M.B.B.S. Preeti Singh M.D. Carlos Martinez Hernandez M.D. Mohammed Waseemuddin M.B.B.S. Navin C. Nanda M.D. 《Echocardiography (Mount Kisco, N.Y.)》2010,27(5):594-596
We describe the value of live/real time three‐dimensional transthoracic echocardiography (3DTTE) over two‐dimensional transthoracic echocardiography (2DTTE) in the assessment of inferior vena cava (IVC) and hepatic vein (HV) obstruction in a patient with sickle cell disease. 3DTTE provided additional information when compared to 2DTTE by (1) identifying the obstructing lesion as a likely thrombus, (2) by providing assessment of anatomical severity of IVC lumen obstruction since the thrombus could be visualized en face also, and (3) identifying an area of increased mobility of a portion of the thrombus suggesting greater risk of embolization. (Echocardiography 2010;27:594‐596) 相似文献
107.
K. Gopal Kishor Kumar R. Nandini P. Jahan M. J. Mahesh Kumar 《Journal of thrombosis and thrombolysis》2010,30(2):154-163
We studied and compared the efficiency of induction aneurysm in apo E mice by using high fat diet and Ang II. Aneurysm induced
in 6 week old male apo E −/− mice by subcutaneous release of Ang II injection for 45 days. Also, aneurysm was induced in three
month old male apo E by administration of high fat diet for a period of three months. No difference in body weight in Ang
II treated mice. But, increase in body weight and mean arterial blood pressure observed in high fat diet group animals. Highly
significant increase in total cholesterol, TG, LDL and significant decrease in HDL level were observed in Ang II treated animals.
Significant increase in total cholesterol, but no changes in TG, LDL, HDL levels were observed in high fat diet group. Higher
percentage of circulating monocytes was observed in ang II treated group but more number of circulating lymphocytes were observed
in high fat diet group in FACS analysis. In histopathology, intimal layer of abdominal aorta was completely replaced by chronic
inflammatory cells particularly macrophages (80%) which appeared as foam cells and lymphocytes (20%) in ang II treated animals.
Degradation of elastin, infiltration of lymphocytes, chondrocytes and cellular migration towards media were observed in the
abdominal aorta of high fat diet group. Real time analysis and immunofluorescence assay supports over expression of Vcam 1
Icam1, MCP 1and MMP2 genes were observed in Ang II treated animals. In immunofluorescence assay, over expression of Mac 3
protein specific for macrophages was observed in abdominal aorta of ang II treated animals, but over expression of CD45.1
& 45.2 proteins specific to lymphocytes were observed in high fat diet group. Based on our observations, Ang II induced aortic
aneurysm by recruiting/ proliferating circulating monocytes by up regulating Icam-1, Vcam -1 and MCP-1. Also, ang II involved
in degradation of elastin in the abdominal aorta by up regulation of MMP2 to promote agranulocytes migration in the intimal
layers. Epithelial cell hyperplasia with accumulation of fatty fluids (cyst) was observed in seminal vesicle and ventral prostate
of high fat treated animals. Fatty degeneration, germ cell apoptosis and infiltration giant cells were observed in the testes
of high fat diet group. As per available literature these observations were not reported with high fat diet treatments with
apo E models. High fat diet induced aneurysm prominently in abdominal, thoracic aorta and extensive plaque formation was observed
in femoral and renal arteries. Administration of high fat diet containing cholesterol induced aneurysm in apo E mice model
also efficient method to rule out the pathogenesis of aortic aneurysm when compared with angiotensin. 相似文献
108.
Osteochondritis dissecans (OCD) is an idiopathic condition affecting the articular epiphysis. Initially described in the knee,
this entity affects several other parts of the body such as the talar dome, tarsal navicular, and femoral capital epiphysis.
OCD of the elbow primarily involves the capitellum. OCD involving the trochlea has rarely been reported. We describe an unusual
and interesting case of OCD affecting the trochlea, mimicking a pseudointercondylar notch. 相似文献
109.
110.
Annamarie Mauelshagen Lynn C Sadler Helen Roberts Mahesh Harilall Cynthia M Farquhar 《Reproductive health》2009,6(1):16-6