Apical hypertrophic cardiomyopathy and ventricular tachycardia

Apical hypertrophic cardiomyopathy was originally reported fromJapan as one of the subsets of hypertrophic cardiomyopathy withoutgradient, usually associated with deep T-wave inversion anda spade-like appearance of the left ventricle. Although manyreports from Japan have indicated that these patients with apicalhypertrophic cardiomyopathy are mostly asymptomatic and haverelatively good prognosis, data on serious ventricular arrhythmiasare not yet available. Present documentation of ventriculartachycardia in a patient with this disease suggests that atleast some of such patients are also at risk of sudden deathand that a systematic study for life-threatening arrhythmiaby ambulatory electrocardiographic monitoring may be necessaryin these cases.     

Lymphomatoid papulosis type D in a Chinese young man: a newly recognized variant

To the editor： We report a 23-year-old Chinese man, who presented with a 2-month history of recurrent eruptions of asymptomatic, red, necrotic papules on his face and extremities. The skin lesions would regress spontaneously within several days, leaving atrophic scars. He had no systemic symptoms. A physical examination revealed many papules and nodules on his trunk and extremities （Figure I A）. Some papules had a necrotic center covered by black crusts. No lymphadenopathy was found.     

Fetal intrapericardial extralobar pulmonary sequestration

To the editor： A 31-year-old primigravida was referred to our hospital at 20 weeks of gestation. Ultrasound examinations were performed using a Prosound a l0 （Aloka Co, Ltd, Tokyo, Japan） with a 2-6 MHz transabdominal probe. The initial sonographic findings were suggestive of a hyperechoic, homogeneous, and well-defined mass on the right lower lung, 18 mm at its maximum dialneter. There were no other abnormalities.     

Catheter-directed intervention and thrombolysis for the treatment of massive pulmonary embolism that caused cardiac arrest

To the editor：Massive pulmonary embolism （PE）,defined as PE with a systolic arterial pressure less than 90 mmHg （1 mmHg=0.133 kPa）,is potentially lethal condition with mortality rate between 30% and 60%.1 In addition to anticoagulation,the standard medical management for massive PE is systemic thrombolysis.2 If there are contraindications,catheter-directed intervention or surgical embolectomy is another choice.     

Localization of transglutaminase 1 mRNA in normal and psoriatic epidermis by non-radioactive in situ hybridization

We examined the expression of the transglutaminase 1 (TGase 1) gene IN frozen sections of normal and psoriatic epidermis by means of non-radioactive in situ hybridization with digoxigenin-labelied cRNA probes. TGase l mRNA was expressed in the granular layer of normal epidermis. regardless of ortho-or hyperkeratosis. However, in psoriatic epidermis. TGasel mRNA was detected in the suprabasal spinous layer, but not in the subcorneal layer. These results indicate that TGase 1 gene expression is limited to the last stage of keratinization in normal epidermis and this regulation is disturbed in psoriasis.     

上海图书馆馆藏抄本医书《增补〈病机提要〉》考析

[目的]通过对上海图书馆藏孤抄本医书《增补〈病机提要〉》的研究,以辨明其作者,并对该书的内容及价值进行介绍。[方法]从地方志中的相关记载入手,以辨明该书编著者;并利用地方志中的有关资料,系统梳理编著者的生平及著作情况;运用文献学方法,对《增补〈病机提要〉》的内容进行考察。[结果]通过研究地方志,发现该书由明代医家陈时荣原著,后经名医秦景明增订而成;并对秦氏的生平、籍贯、交游、学术传承及著作情况等作了梳理;研究是书内容后发现,该书体例精当,便于查检,论治精详,征引广泛,具有临床应用手册的性质,又经秦氏增补,具有较高的理论和临床价值,值得深入研究。[结论]以《增补〈病机提要〉》为例,稿抄本医书中蕴藏着丰富的宝藏,是中医古籍文献的重要组成部分,具有很高的学术和临床价值,希望更多有志之士投身于此,使其学渐为兴盛。