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FRANCISCO J. MIRANDA JOS A. ALABADÍ MARTA ORTÍ JOSE M. CENTENO MARTA PI
N ALBERTO YUSTE JUAN F. SANZ-CERVERA J. ALBERTO MARCO ENRIQUE ALBORCH 《The Journal of pharmacy and pharmacology》1998,50(2):237-241
We have analysed the effects of 2,3-diepiingol 7,12-diacetate-8-isobutyrate (compound 1 ), ingenol-3-angelate-17-benzoate (compound 2 ), ingenol-3-angelate-17-benzoate-20-acetate (compound 3 ) and 3,5,7,8,9,15-hexahydroxyjatropha-6(17),11-dien-14-one-5,8-bis(2-methylbutyrate)-7-(2-methylpropionate) (compound 4 ), four diterpenes isolated from E. canariensis, on the isometric tension developed by isolated rabbit basilar and carotid arteries. Concentration-response curves to these compounds were obtained cumulatively in both arteries at resting tension and active tone (KCl, 50 mM). At resting tension a concentration-dependent contraction was induced by the four compounds. In the basilar artery the order of potency was 3 = 1 > 2 = 4 , without significant differences between Emax values. In the carotid artery the order of potency was 3 > 2 = 1 = 4 and there were no significant differences between the Emax (maximum effect) values of compounds 1–3 , all of which were higher than that of compound 4 . In pre-contracted basilar artery compounds 1–3 induced concentration-dependent relaxation and compound 4 was almost ineffective; the order of potency was 3 > 2 = 1 without significant differences between Emax values. In the carotid artery with active tone the four compounds tested induced further contractions; the order of potency was 3 > 2 = 4 > 1 without significant differences between Emax values. These results show that the four diterpenes are potent active substances in rabbit basilar and carotid arteries and that there are regional differences between their action. The four compounds tested contract basilar and carotid arteries at resting tension. Compounds 1–3 relax pre-contracted basilar artery but not carotid artery. 相似文献
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MARTA ELIAN 《Epilepsia》1972,13(1):51-56
The importance of Service in the Army in the Israeli child's development and future has to be recognized. Rejection solely because of epilepsy affects only about a quarter of the epileptic youngsters, less than it seemed at first glance; most of them do reasonably well in civil life and probably would be able to do as well in a non-combat unit of the Army, which would be to them like full rehabilitation. The fact that the 14 accepted, or about a quarter of the boys who applied, did quite well in the Army, supports the notion that a plan could be worked out which would benefit both the Army and the youngsters. 相似文献
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FELIX BOURIER M.D. GABRIELE HESSLING M.D. SONIA AMMAR‐BUSCH M.D. MARC KOTTMAIER M.D. ALESSANDRA BUIATTI M.D. CHRISTIAN GREBMER M.D. MARTA TELISHEVSKA M.D. VERENA SEMMLER M.D. CARSTEN LENNERZ M.D. CHRISTINE SCHNEIDER R.N. CHRISTOF KOLB M.D. ISABEL DEISENHOFER M.D. TILKO REENTS M.D. 《Journal of cardiovascular electrophysiology》2016,27(3):347-350
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One Year Incidence of Atrial Septal Defect after PV Isolation: A Comparison Between Conventional Radiofrequency and Cryoballoon Ablation
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GIACOMO MUGNAI M.D. JUAN SIEIRA M.D. GIUSEPPE CICONTE M.D. MARTA SORIANO HERVAS M.D. GHAZALA IRFAN M.D. YUKIO SAITOH M.D. BURAK HÜNÜK M.D. ERWIN Ströker M.D. VEDRAN VELAGIC M.D. KRISTEL WAUTERS M.D. CLAUDIO TONDO M.D. Ph.D. GIULIO MOLON M.D. CARLO DE ASMUNDIS M.D. Ph.D. PEDRO BRUGADA M.D. Ph.D. GIAN‐BATTISTA CHIERCHIA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2015,38(9):1049-1057
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TILKO REENTS M.D. ALLESSANDRA BUIATTI M.D. SONIA AMMAR M.D. ROGER DILLIER M.D. VERENA SEMMLER M.D. MARTA TELISHEVSKA M.D. FELIX BOURIER M.D. CARSTEN LENNERZ M.D. CHRISTIAN GREBMER M.D. BERNHARDT KAESS M.D. CHRISTOF KOLB M.D. GABRIELE HESSLING M.D. ISABEL DEISENHOFER M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(6):700-705