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101.
B.Y. Fei H.X. Lv W.H. Zheng 《Brazilian journal of medical and biological research》2014,47(2):166-170
Intestinal tuberculosis (ITB) and Crohn''s disease (CD) are granulomatous
disorders with similar clinical manifestations and pathological features that
are often difficult to differentiate. This study evaluated the value of
fluorescent quantitative polymerase chain reaction (FQ-PCR) for
Mycobacterium tuberculosis (MTB) in fecal samples and
biopsy specimens to differentiate ITB from CD. From June 2010 to March 2013, 86
consecutive patients (38 females and 48 males, median age 31.3 years) with
provisional diagnoses of ITB and CD were recruited for the study. The patients''
clinical, endoscopic, and histological features were monitored until the final
definite diagnoses were made. DNA was extracted from 250 mg fecal samples and
biopsy tissues from each patient. The extracted DNA was amplified using FQ-PCR
for the specific MTB sequence. A total of 29 ITB cases and 36 CD cases were
included in the analysis. Perianal disease and longitudinal ulcers were
significantly more common in the CD patients (P<0.05), whereas night sweats,
ascites, and circumferential ulcers were significantly more common in the ITB
patients (P<0.05). Fecal FQ-PCR for MTB was positive in 24 (82.8%) ITB
patients and 3 (8.3%) CD patients. Tissue PCR was positive for MTB in 16 (55.2%)
ITB patients and 2 (5.6%) CD patients. Compared with tissue FQ-PCR, fecal FQ-PCR
was more sensitive (X2=5.16, P=0.02). We conclude that FQ-PCR for MTB
on fecal and tissue samples is a valuable assay for differentiating ITB from CD,
and fecal FQ-PCR has greater sensitivity for ITB than tissue FQ-PCR. 相似文献
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108.
Yuli R Tak Rinka MP Van Zundert Rowella CWM Kuijpers Boukje S Van Vlokhoven Hettie FW Rensink Rutger CME Engels 《BMC public health》2012,12(1):21
Background
The incidence of depressive symptoms increases during adolescence, from 10.0% to 24.5% at age 11 to 15, respectively. Experiencing elevated levels of depressive symptoms increases the risk of a depressive disorder in adulthood. A universal school-based depression prevention program Op Volle Kracht (OVK) was developed, based on the Penn Resiliency Program, aimed at preventing the increase of depressive symptoms during adolescence and enhancing positive development. In this study the effectiveness of OVK will be tested and possible mediators of program effects will be focus of study as well. 相似文献109.
目的 了解县城乡镇初中生幸福感水平及其影响因素.方法 采用Rosenberg自尊问卷、一般自我效能感量表和中学生应对方式问卷等对706名初中生进行调查.结果 觉得“很幸福”或“幸福”的学生占70.4%;女生的幸福感水平显著高于男生(x2=9.714,P<0.01);家庭经济状况较好的学生,幸福感水平较高(x2=58.184,P<0.001);幸福感水平年级间无显著差异(x2=0.471,P>0.05);自尊、自我效能感、问题解决、寻求社会支持、积极的合理化解释得分幸福组显著高于非幸福组(t1=9.257,t2=3.988,t3=4.245,t4=4.150,t5=5.184,P5<0.001).忍耐、“幻想、否认”、逃避得分幸福组显著低于非幸福组(t1=-3.090,t2=-3.073,Ps<0.01;t3=-3.830,P<0.001).家庭经济状况、自尊、寻求社会支持、逃避应对方式能显著预测县城乡镇初中生的幸福感(x2=136.165,P<0.001).结论 县城乡镇初中生总体上是幸福的,性别、家庭经济状况、自尊、自我效能感和应对方式等因素会影响其幸福感水平,并且家庭经济状况、自尊、寻求社会支持及逃避应对方式能有效预测其幸福感水平. 相似文献
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