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81.
Wronski M Skrok-Wolska D Samochowiec J Ziolkowski M Swiecicki L Bienkowski P Korkosz A Zatorski P Kukwa W Scinska A 《Alcohol and alcoholism (Oxford, Oxfordshire)》2007,42(2):75-79
AIMS: The aim of the present study was to evaluate a possible relationship between taste responses to sweet solutions and alcoholic status. METHODS: The rated intensity and pleasantness of sucrose taste was compared in male alcoholics (n = 45) and non-alcoholic controls (n = 33). RESULTS: The rated intensity, but not pleasantness, of water taste (0% sucrose) was higher in the alcoholics. The two groups did not differ with respect to the rated intensity or pleasantness of sucrose solutions (1-30%). The proportion of sweet-likers, i.e. subjects rating 30% sucrose as most pleasant, was similar in both groups (the controls: 57.6%, the alcoholics: 62.2%). A subgroup of alcoholics with a paternal history of alcoholism (n = 22) rated the highest sucrose concentration as more pleasant compared to alcoholics without alcoholic fathers. The proportion of sweet-likers among the alcoholics with a paternal history of alcoholism (77.3%) was significantly higher than that found in the alcoholics without a familial history of alcoholism (47.8%). CONCLUSIONS: The present results suggest the following: (i) alcohol dependence is not associated with any major alterations in taste responses to sucrose solutions, (ii) sweet liking is a phenotypic marker of male alcoholics with a paternal history of alcoholism. 相似文献
82.
Dejneka W Sworczak K Obołończak L Lukasiak J 《Roczniki Państwowego Zak?adu Higieny》2007,58(3):563-567
The aim of this study was to estimate the concentration of total selenium in serum women with thyroid gland disease. Selenium was determined by atomic absorption spectrometry using the hydride generation method (HG-AAS). Research was determined in 94 patients with thyroid gland disease and in 28 healthy controls. Selenium concentration of serum was variously in patients than in control group and patients with different thyroid gland diseases. Concentration in control group was 0.06231 microg/ml, in goitre group--0.05612 microg/ml, in hyperthyroidism--0.07149 microg/ml and in hypothyroidism--0.09088 microg/ml. 相似文献
83.
Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy
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84.
Marta Pokrywczynska Marzena Anna Lewandowska Sandra Krzyzanowska Arkadiusz Jundzill Marta Rasmus Karolina Warda Maciej Gagat Aleksander Deptula Anna Helmin-Basa Marcin Holysz Maciej Nowacki Lukasz Buchholz Magdalena Bodnar Andrzej Marszalek Alina Grzanka Wojciech Jozwicki Jacek Michalkiewicz Tomasz Drewa 《Archivum immunologiae et therapiae experimentalis》2015,63(5):377-384
85.
Relationship between tumour necrosis factor‐related apoptosis inducing ligand (TRAIL) and vascular endothelial growth factor in human multiple myeloma patients
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Lukasz Bolkun Dorota Lemancewicz Jaroslaw Piszcz Marcin Moniuszko Urszula Bolkun‐Skornicka Malgorzata Szkiladz Ewa Jablonska Janusz Kloczko Janusz Dzieciol 《Hematological oncology》2015,33(4):199-205
Tumour necrosis factor‐alfa (TNF‐α) is an inflammatory cytokine with a wide spectrum of biological activity, including angiogenesis. Tumour necrosis factor‐related apoptosis inducing ligand (TRAIL), which belongs to the TNF family of proteins, plays a role in the regulation of vascular responses, but its effect on the formation of new blood vessels (angiogenesis) is unclear. We analysed TRAIL concentrations in parallel with pro‐angiogenic cytokines in serum and their expression in trephine biopsy (TB) in 56 patients with newly diagnosed IgG MM and 24 healthy volunteers. The study showed statistically higher concentrations of TRAIL and TNF‐α, as well as of VEGF and its receptor, in MM patients compared to healthy volunteers and patients in advanced stages of the disease. Furthermore, we observed a significant decrease in all studied pro‐angiogenic cytokines and significant increase of TRAIL concentration after anti‐angiogenic therapy, with meaningful differences between responders (at least partial remission) and patients with progression during the induction treatment. It was also established that TRAIL correlated statistically and negatively with pro‐angiogenic cytokines such as VEGF with its receptor and expression of VEGF and syndecan‐1 in TB. In summary, our data indicate that in MM patients, both clinical course and treatment responsiveness are associated with dynamic yet corresponding changes of levels of TRAIL parallel pro‐angiogenic mediators such as VEGF with its receptor and expression of VEGF and syndecan‐1 in TB. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
86.
Vinicius P. Fardin Estevam A. Bonfante Paulo G. Coelho Malvin N. Janal Nick Tovar Lukasz Witek Dimorvan Bordin Gerson Bonfante 《Dental materials》2018,34(2):260-271
Objective
To evaluate the residual stress (nanoindentation based on hardness) of fatigued porcelain-fused to zirconia 3-unit fixed dental prostheses (FDP) with different framework designs.Methods
Twenty maxillary 3-unit FDP replacing second-premolar (pontic) were fabricated with conventional framework-design (even-thickness of 0.5 mm and 9 mm2 connector area) and modified framework-design (thickness of 0.5 mm presenting lingual collar connected to proximal struts and 12 mm2 connector area). Connector marginal ridges were loaded and the fractured and suspended FDPs were divided (n = 3/each) into: (1) Fractured zirconia even-thickness (ZrEvenF); (2) Suspended zirconia even-thickness (ZrEvenS); (3) Fractured zirconia with modified framework (ZrModF); (4) Suspended zirconia with modified framework (ZrModS); (5) Non-fatigued FDP with conventional framework design (Control). The FDPs were nanoindented at 0.03 mm (Region of Interest (ROI) 1), 0.35 mm (ROI 2) and 1.05 mm (ROI 3) distances from porcelain veneer outer surface with peak load 4000 μN. The Linear Mixed Analysis of Variance (ANOVA) Model on ranks and Least Significant Difference Test on ranks (95%) were used.Results
Highest rank hardness values were found for Control group and ZrModS, whereas the lowest values were found in ZrModF. Statistical differences (p = 0.000) were found among all groups except for comparison between ZrModS and Control group (p = 0.371). Hardness between ROIs were statistically significant different (p < 0.001) where ROI 1 presented the lowest values.Significance
Framework-design modification did not influence the residual stress of porcelain-fused to zirconia fatigued 3-unit FDP. Whereas fractured FDPs showed the highest residual stress compared to suspended and control FDPs. Residual stress increased as nanoindented away from framework. 相似文献87.
Benjamin Gabriel Poulson Kacper Szczepski Joanna Izabela Lachowicz Lukasz Jaremko Abdul-Hamid Emwas Mariusz Jaremko 《RSC advances》2019,10(1):215
The process of aggregation of proteins and peptides is dependent on the concentration of proteins, and the rate of aggregation can be altered by the presence of metal ions, but this dependence is not always a straightforward relationship. In general, aggregation does not occur under normal physiological conditions, yet it can be induced in the presence of certain metal ions. However, the extent of the influence of metal ion interactions on protein aggregation has not yet been fully comprehended. A consensus has thus been difficult to reach because the acceleration/inhibition of the aggregation of proteins in the presence of metal ions depends on several factors such as pH and the concentration of the aggregated proteins involved as well as metal concentration level of metal ions. Metal ions, like Cu2+, Zn2+, Pb2+etc. may either accelerate or inhibit aggregation simply because the experimental conditions affect the behavior of biomolecules. It is clear that understanding the relationship between metal ion concentration and protein aggregation will prove useful for future scientific applications. This review focuses on the dependence of the aggregation of selected important biomolecules (peptides and proteins) on metal ion concentrations. We review proteins that are prone to aggregation, the result of which can cause serious neurodegenerative disorders. Furthering our understanding of the relationship between metal ion concentration and protein aggregation will prove useful for future scientific applications, such as finding therapies for neurodegenerative diseases.The process of aggregation of proteins and peptides is dependent on the concentration of proteins, and the rate of aggregation can be altered by the presence of metal ions, but this dependence is not always a straightforward relationship. 相似文献
88.
Krzych LJ 《Polskie Archiwum Medycyny Wewn?trznej》2008,118(3):132-142
Bayes's theorem is predominantly used in diagnosing based on the results of various diagnostic tests. This statistical approach is intuitive in differential diagnosis as it explicitly takes into consideration data from medical history, physical examination, laboratory findings and imaging. Bayes's theorem states that the probability of disease occurrence (or occurrence of other outcome) after new information is obtained, called a posteriori probability, depends directly on an a priori probability and the value of likelihood ratio associated with a given test result. This paper describes basic Bayesian analysis in relation to the diagnosis of two types of secondary hypertension; primary aldosteronism and pheochromocytoma. This choice is based on two facts; primary aldosteronism is believed to be the most common and the most commonly detected cause of symptomatic hypertension and pheochromocytoma is thought to have rapid progress and stormy clinical course. This article aims to draw physicians' attention to and increase the knowledge of Bayesian analysis, and to describe its use in everyday clinical decision making. On the basis of this theorem's foundations, the discussion in relation to the issue of differential diagnosis between physicians, their patients, and medical students should also improve. When used in practice, one should be aware, however, of Bayesian analysis limitations concerning the diagnostic test application and limited knowledge of diagnostic test accuracy, and insecure or faulty a priori probability estimates. 相似文献
89.
90.