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排序方式: 共有2307条查询结果,搜索用时 15 毫秒
81.
Agustín Ruiz Isabel Hernández Maiteé Ronsende-Roca Antonio González-Pérez Emma Rodriguez-Noriega Reposo Ramírez-Lorca Ana Mauleón Concha Moreno-Rey Lucie Boswell Larry Tune Sergi Valero Montserrat Alegret Javier Gayán James T. Becker Luis Miguel Real Lluís Tárraga Clive Ballard Michael Terrin Stephanie Sherman Haydeh Payami Oscar L. López Jacobo E. Mintzer Mercè Boada 《Neurobiology of aging》2014
82.
Clinical characteristics in patients with interstitial deletions of chromosome region 12q21–q22 and identification of a critical region associated with keratosis pilaris
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83.
Petr Kuglik Jan Smetana Vladimira Vallova Lucie Moukova Katerina Kasikova Michaela Cvanova Lucie Brozova 《International journal of clinical and experimental pathology》2014,7(8):5071-5082
Alterations in the genome that lead to changes in DNA sequence copy number are characteristic features of solid tumors. We used CGH+SNP microarray and HPV-FISH techniques for detailed screening of copy number alterations (CNAs) in a cohort of 26 patients with cervical carcinoma (CC). This approach identified CNAs in 96.2% (25/26) of tumors. Array-CGH discovered CNAs in 73.1% (19/26) of samples, HPV-FISH experiments revealed CNAs in additional 23.1% (6/26) of samples. Common gains of genetic sequences were observed in 3q (50.0%), 1q (42.4%), 19q (23.1%), while losses were frequently found in 11q (30.8%), 4q (23.1%) and 13q (19.2%). Chromosomal regions involved in loss of heterozygosity were observed in 15.4% of samples in 8q21, 11q23, 14q21 and 18q12.2. Incidence of gain 3q was associated with HPV 16 and HPV 18 positive samples and simultaneous presence of gain 1q (P = 0.033). We did not found a correlation between incidence of CNAs identified by array-CGH and HPV strain infection and incidence of lymph node metastases. Subsequently, HPV-FISH was used for validation of array-CGH results in 23 patients for incidence of hTERC (3q26) and MYC (8q24) amplification. Using HPV-FISH, we found chromosomal lesions of hTERC in 87.0% and MYC in 65.2% of specimens. Our findings confirmed the important role of HPV infection and specific genomic alterations in the development of invasive cervical cancer. This study also indicates that CGH+SNP microarrays allow detecting genome-wide CNAs and copy-neutral loss of heterozygosity more precisely, however, it may be less sensitive than FISH in samples with low level clonal CNAs. 相似文献
84.
This article is focused on the comparison of the reliability of the results obtained by image analysis (newly proposed evaluation method) with well-known methods of evaluation of long-term corrosion resistance of glass fibers in an alkaline environment (pH > 12). The developed method is based on the analysis of scanning electron microscopy images (diameter and structures on the fiber surface). An experiment (52 weeks) was performed to evaluate two types of glass fibers: anticorrosive glass fibers (ARGFs) and E-glass fibers (EGFs). Three media were used to treat the fibers (23 ± 2 °C): H2O, Ca(OH)2, and K2SiO3. The ARGFs’ tensile strength did not reduce; a decrease by 68% was observed for EGFs in H2O. Tensile strength decreased by 32% and 85–95% in K2SiO3; by 50% and 64% in Ca(OH)2 for the ARGF and EGF, respectively. Statistical analysis was performed to validate the reliability and plausibility of the developed method. ARGFs and EGFs did not show any relationship between the fiber diameter and weight in H2O; however, the linear trends may predict this relationship in Ca(OH)2 and K2SiO3. For the ARGF and EGF, the cubic trend was suitable for predicting the change in fiber weight and diameter over time in Ca(OH)2 and K2SiO3. 相似文献
85.
Background: High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the sterilization of human breast milk (BM). HHP preserves numerous milk bioactive factors that are degraded by HoP, but no data are available for milk apelin and glucagon-like peptide 1 (GLP-1), two hormones implicated in the control of glucose metabolism directly and via the gut–brain axis. This study aims to determine the effects of HoP and HHP processing on apelin and GLP-1 concentrations in BM and to test the effect of oral treatments with HoP- and HHP-BM on intestinal contractions and glucose metabolism in adult mice. Methods: Mice were treated by daily oral gavages with HoP- or HHP-BM during one week before intestinal contractions, and glucose tolerance was assessed. mRNA expression of enteric neuronal enzymes known to control intestinal contraction was measured. Results: HoP-BM displayed a reduced concentration of apelin and GLP-1, whereas HHP processing preserved these hormones close to their initial levels in raw milk. Chronic HHP-BM administration to mice increased ileal mRNA nNos expression level leading to a decrease in gut contraction associated with improved glucose tolerance. Conclusion: In comparison to HoP, HPP processing of BM preserves both apelin and GLP-1 and improves glucose tolerance by acting on gut contractions. This study reinforces previous findings demonstrating that HHP processing provides BM with a higher biological value than BM treated by HoP. 相似文献
86.
Lucie Cases Pauline Adler Franck Pelissier Sbastien Diliberto Clotilde Boulanger Claude Grison 《RSC advances》2021,11(45):28085
In parallel with increasing Ni production and utilisation, Ni pollution in the soil–water continuum has become an alarming and global problem. Solutions for removing Ni from industrial effluents have been widely investigated and biosorption has emerged as an efficient, cost-effective, scalable and sustainable alternative for water treatment. However, the biosorption capacity is limited by the chemical composition of the biomaterial and the Ni-enriched biomaterials are rarely valorised. In this work, the biosorption capacity of three abundant biomaterials with different chemical properties – water hyacinth, coffee grounds and pinecones – was studied before and after functionalization, and reached a maximum biosorption capacity of 51 mg g−1 of Ni(ii). A bioinspired functionalization approach was investigated introducing carboxylate moieties and was conducted in green conditions. The Ni-enriched biomaterials were valorised by transformation into catalysts, which were characterised by MP-AES and XRPD. Their characterisation revealed a structure similar to nickel formate, and hence the Eco-Ni(HCOO)2 catalysts were tested in Suzuki–Miyaura reactions. Several aryl iodides were successfully cross-coupled to phenylboronic acids using Eco-Ni(HCOO)2 without any ligand, a mild and green base in a mixture of green solvents.New biomaterials were functionalised for biosorption of Ni from aqueous solutions and valorised as ecocatalysts in Suzuki–Miyaura green reactions. 相似文献
87.
Cdric Rossi Marie Tosolini Pauline Gravelle Sarah Pericart Salim Kanoun Solene Evrard Julia Gilhodes Don-Marc Franchini Nadia Amara Charlotte Syrykh Pierre Bories Lucie Oberic Loïc Ysebaert Laurent Martin Selim Ramla Philippine Robert Claire Tabouret-Viaud Ren-Olivier Casasnovas Jean-Jacques Fourni Christine Bezombes Camille Laurent 《Haematologica》2022,107(1):221
88.
Brice Mastrovito Chlo Naimi Leslie Kouam Xavier Naudot Lucie Fournier Guillaume Spaccaferri Jean-Christophe Plantier Anaïs Soares Fabienne De Oliveira Marie Gueudin Vronique Jacomo Cline Leroy Alice Moisan Mlanie Martel 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(6)
Three confirmed infections with the SARS-CoV-2 B.1.640 variant under monitoring were reported in Normandy, north-western France in late November 2021. Investigations led to the identification of two events linked to the same cluster. A total of 75 confirmed and probable B.1.640 cases were reported. All had completed the primary vaccination series. Sixty-two cases were older than 65 years. Fifty-six cases had symptoms and four were hospitalised. This investigation provides preliminary results concerning a variant with limited information currently available. 相似文献
89.
Katharina C. Khler Jessica C. Hassel Lucie Heinzerling Carmen Loquai Kai‐Martin Thoms Selma Ugurel Lisa Zimmer Ralf Gutzmer 《Journal der Deutschen Dermatologischen Gesellschaft》2020,18(6):582-609
CTLA‐4 and PD‐1 play a key role in tumor‐induced downregulation of lymphocytic immune responses. Immune checkpoint inhibitors have been shown to alter the immune response to various cancer types. Anti‐CTLA‐4 and anti‐PD‐1 antibodies affect the interaction between tumor, antigen‐presenting cells and T lymphocytes. Clinical studies of the anti‐CTLA‐4 antibody ipilimumab and the anti‐PD‐1 antibodies nivolumab and pembrolizumab have provided evidence of their positive effects on overall survival in melanoma patients. Combined treatment using ipilimumab and nivolumab has been shown to achieve five‐year survival rates of 52 %. Such enhancement of the immune response is inevitably associated with adverse events. Knowledge of the spectrum of side effects is essential, both in terms of prevention and management. Adverse events include colitis, dermatitis, hypophysitis, thyroiditis, hepatitis and other, less common autoimmune phenomena. In recent years, considerable progress has been made in the detection and treatment of the aforementioned immune‐related adverse events. However, early diagnosis of rare neurological or cardiac side effects, which may be associated with increased mortality, frequently pose a challenge. The present update highlights our current understanding as well as new insights into the spectrum of side effects associated with checkpoint inhibitors and their management. 相似文献
90.
Garel Juliette Blondiaux Eléonore Della Valle Valeria Guilbaud Lucie Khachab Farah Jouannic Jean-Marie Ducou le Pointe Hubert Garel Catherine 《Pediatric radiology》2020,50(4):575-582
A wide range of genitourinary pathologies can be diagnosed in utero, from a simple vesicoureteral reflux to a more complex disorder of sexual differentiation. The prognosis and neonatal management of these conditions differ significantly. Evaluation of the fetal perineal anatomy is paramount to making the right diagnosis. The aim of this pictorial essay is to show sonographers how to acquire a perineal midsagittal view in a male fetus, and to demonstrate how this specific view allows assessment of the urethra and penis, to differentiate various genitourinary pathologies.
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