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991.
André Luciano Baitello Francisco de Assis Cury Paulo César Espada Rogério Yukio Morioka José Maria Pereira de Godoy 《International journal of emergency medicine》2010,3(2):91-95
Background and aim:
The aim of this study was to evaluate if loss of consciousness at the scene of an accident in patients with thoracic trauma classified by the Abbreviated Injury Scale (AIS) as thorax >2 has a different outcome in respect to immediate hospital discharge, hospitalization, death and type of accident.Methods:
A prospective study was performed in the Regional Trauma Center of São José do Rio Preto. All patients with scores related to thoracic injury ≥2 were included in this study. Thus, 134 patients with penetrating and 231 with blunt thoracic injuries were evaluated. The chi-square, Fisher's exact and relative risk tests were utilized for statistical analysis with an alpha error greater than 5% (p?0.05) being considered statistically significant.Results:
A significantly higher number of patients who lost consciousness (35–33.9%) died compared to those who did not lose consciousness (9–3.5%, Fisher's exact test: p?0.0001) where the relative risk (RR) of death when an individual lost consciousness was 9.7 (95% CI: 4.8–19.4). In respect to the necessity of hospital treatment, those who lost consciousness were more commonly hospitalized (Fisher's exact test: p?0.0001).Conclusion:
The loss of consciousness at the time of trauma is a warning sign in patients with thoracic injuries whether associated with other types of injuries or not. 相似文献992.
Di Gennaro E Piro G Chianese MI Franco R Di Cintio A Moccia T Luciano A de Ruggiero I Bruzzese F Avallone A Arra C Budillon A 《British journal of cancer》2010,103(11):1680-1691
Background:
Potentiation of anticancer activity of capecitabine is required to improve its therapeutic index. In colorectal cancer (CRC) cells, we evaluated whether the histone deacetylase-inhibitor vorinostat may induce synergistic antitumour effects in combination with capecitabine by modulating the expression of thymidine phosphorylase (TP), a key enzyme in the conversion of capecitabine to 5-florouracil (5-FU), and thymidylate synthase (TS), the target of 5-FU.Methods:
Expression of TP and TS was measured by real-time PCR, western blotting and immunohistochemistry. Knockdown of TP was performed by specific small interfering RNA. Antitumour activity of vorinostat was assessed in vitro in combination with the capecitabine active metabolite deoxy-5-fluorouridine (5′-DFUR) according to the Chou and Talay method and by evaluating apoptosis as well as in xenografts-bearing nude mice in combination with capecitabine.Results:
Vorinostat induced both in vitro and in vivo upregulation of TP as well as downregulation of TS in cancer cells, but not in ex vivo treated peripheral blood lymphocytes. Combined treatment with vorinostat and 5′-DFUR resulted in a synergistic antiproliferative effect and increased apoptotic cell death in vitro. This latter effect was impaired in cells where TP was knocked. In vivo, vorinostat plus capecitabine potently inhibited tumour growth, increased apoptosis and prolonged survival compared with control or single-agent treatments.Conclusions:
Overall, this study suggests that the combination of vorinostat and capecitabine is an innovative antitumour strategy and warrants further clinical evaluation for the treatment of CRC. 相似文献993.
Luciano Cardinale Adriano Massimiliano Priola Federica Moretti Giovanni Volpicelli 《World journal of radiology》2014,6(6):230-237
Hydrostatic pulmonary edema is as an abnormal increase in extravascular water secondary to elevated pressure in the pulmonary circulation, due to congestive heart failure or intravascular volume overload. Diagnosis of hydrostatic pulmonary edema is usually based on clinical signs associated to conventional radiography findings. Interpretation of radiologic signs of cardiogenic pulmonary edema are often questionable and subject. For a bedside prompt evaluation, lung ultrasound (LUS) may assess pulmonary congestion through the evaluation of vertical reverberation artifacts, known as B-lines. These artifacts are related to multiple minimal acoustic interfaces between small water-rich structures and alveolar air, as it happens in case of thickened interlobular septa due to increase of extravascular lung water. The number, diffusion and intensity of B lines correlates with both the radiologic and invasive estimate of extravascular lung water. The integration of conventional chest radiograph with LUS can be very helpful to obtain the correct diagnosis. Computed tomography (CT) is of limited use in the work up of cardiogenic pulmonary edema, due to its high cost, little use in the emergencies and radiation exposure. However, a deep knowledge of CT signs of pulmonary edema is crucial when other similar pulmonary conditions may occasionally be in the differential diagnosis. 相似文献
994.
Paolo Emanuele Levi-Setti Luciano Negri Annamaria Baggiani Emanuela Morenghi Elena Albani Valentina Parini Luca Cafaro Carola Maria Conca Dioguardi Amalia Cesana Antonella Smeraldi Armando Santoro 《Journal of assisted reproduction and genetics》2018,35(11):2049-2056
Purpose
To analyse the impact of female characteristics on assisted reproductive technology outcome among male haematological cancer survivors.Methods
A retrospective analysis of 93 haematological cancer survivors attending our tertiary referral fertility centre between June 1998 and June 2017 for achieving fatherhood with assisted reproductive technology treatments.Results
A progressive increase in the median female age was observed during the study period (32.2 years until the year 2007 and 36.9 years from the year 2012). Fifty-five out of 93 patients were treated with intracytoplasmic sperm injection (ICSI) (113 ovarian stimulations, 108 ICSI procedures). Cryopreserved ejaculated sperm was used in 28 couples, fresh sperm in 19, and thawed testicular sperm in 8 couples. Mean female age at ovarian stimulation was 37.0 ± 4.7 years. Twenty-six pregnancies resulted in a full-term birth (23% per started ovarian stimulation; 43.6% per couple) and 33 children were born. No significant differences were observed according to source of sperm (fresh, frozen, testicular) and multivariate analysis confirmed that maternal age was the only variable inversely related to the cumulative delivery rate, being five times lower (15.7%) when the female partner was ≥?40 years (OR?=?0.22, 95% CI 0.06–0.77) vs. 58.3% with younger women (p?=?0.0037).Conclusions
Delayed childbearing and female ageing affect ICSI outcome in couples where the male is a survivor of haematological cancer. This topic should be discussed when counselling male cancer patients about fertility preservation.995.
996.
Volkan
zenci Luciano Rinaldi Natalia Teleshova Darius Matusevicius Pia Kiviskk Mathilde Kouwenhoven Hans Link 《Journal of autoimmunity》1999,12(4):297-303
Matrix metalloproteinases (MMPs) comprise a family of proteolytic enzymes. MMPs are capable of disrupting the blood-brain barrier (BBB), mediating the destruction of extracellular matrix and myelin components. MMPs are also involved in the processing of a variety of cell surface molecules, including the proinflammatory cytokine TNF-alpha. Each of these mechanisms are thought to be important in the pathogenesis of multiple sclerosis (MS). We investigated mRNA expression of MMP-3, MMP-9 and two tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in parallel in blood mononuclear cells (MNC) from patients with MS and controls, using in situ hybridization. Numbers of MMP-9 mRNA-expressing cells in blood were higher in patients with MS compared to other neurological diseases (OND), other inflammatory neurological diseases (OIND) and healthy subjects (P<0.0001 for all comparisons). Patients with MS had also higher levels of MMP-3 and TIMP-1 mRNA expressing blood MNC compared to patients with OND and healthy subjects. A positive correlation was observed for MMP-9 and TIMP-1 mRNA expression in MS. These results demonstrate that MMPs and TIMPs are upregulated in MS and may contribute to the pathogenesis of the disease. 相似文献
997.
Gliomas are the most common infiltrative neoplasms of the optic nerve and can present as two distinct growth patterns: intraneural glial proliferation and perineural arachnoidal gliomatosis (PAG). It has been suggested that perineural arachnoidal gliomatosis is seen almost exclusively in the setting of neurofibromatosis type 1 (NF1). We describe a child with perineural arachnoidal gliomatosis occurring without neurofibromatosis type 1, supported by both radiographic and histological findings. A 4-year-old female without neurofibromatosis type 1 presented with rapidly progressive right-sided proptosis. Magnetic resonance imaging (MRI) revealed an enhancing fusiform intraconal lesion, which was hypointense on T1 and hyperintense on T2-weighted images: characteristic of perineural arachnoidal gliomatosis, the optic nerve was visualized coursing the tumor. Histopathologic study was consistent with perineural arachnoidal gliomatosis. Perineural arachnoidal gliomatosis can develop independent of neurofibromatosis type 1, as demonstrated by this case. 相似文献
998.
Everolimus Plus Exemestane in Advanced Breast Cancer: Safety Results of the BALLET Study on Patients Previously Treated Without and with Chemotherapy in the Metastatic Setting 下载免费PDF全文
Daniele Generali Filippo Montemurro Roberto Bordonaro Antonino Mafodda Sante Romito Andrea Michelotti Pierluigi Piovano Maria Teresa Ionta Claudia Bighin Donata Sartori Antonio Frassoldati Marina Elena Cazzaniga Ferdinando Riccardi Franco Testore Patrizia Vici Carlo Antonio Barone Alessio Schirone Federico Piacentini Franco Nolè Annamaria Molino Luciano Latini Edda Lucia Simoncini Fausto Roila Francesco Cognetti Francesco Nuzzo Jennifer Foglietta Alessandro Marco Minisini Francesca Goffredo Giuseppe Portera Gilda Ascione Gabriella Mariani 《The oncologist》2017,22(6):648-654
999.
1000.
Stamatula Zanetidou MD Martino Belvederi Murri MD Marco Menchetti MD PhD Giulio Toni MD Fabrizio Asioli MD Luigi Bagnoli MD Donato Zocchi MD Matteo Siena MD Barbara Assirelli MD Claudia Luciano MD Mattia Masotti MD Carlo Spezia MD Monica Magagnoli MD Mirco Neri MD PhD Mario Amore MD PhD Klea D. Bertakis MD MPH the Safety Efficacy of Exercise for Depression in Seniors Study Group 《Journal of the American Geriatrics Society》2017,65(2):348-355