High hemoglobin fluctuation was a protective factor for cardiovascular‐related death in peritoneal dialysis (PD) patients: A retrospective analysis of 232 patients with PD

ObjectivesThis study aimed to investigate the effect of hemoglobin (Hb) fluctuation after dialysis on the prognosis of cardiovascular‐related and all‐cause deaths in peritoneal dialysis (PD).MethodsAccording to the Hb fluctuation, patients were divided into low fluctuation group, moderate fluctuation group, and high fluctuation group, and then, the effects of Hb fluctuation after dialysis on the prognosis of cardiovascular‐related and all‐cause death in PD were analyzed by regression analysis.ResultsA total of 232 patients were selected in this study. Compared with the low Hb fluctuation group, the moderate and high fluctuation groups had lower body mass index (BMI), estimated glomerular filtration rate (eGFR), and baseline Hb, and the moderate fluctuation group had less erythropoietin (EPO) and dialysis dose. Compared with survivors, patients with cardiovascular‐related and all‐cause deaths had lower mean Hb and Hb fluctuation (all p < 0.05). Cox regression analysis showed that before and after adjusting for confounding factors, Hb fluctuation was still independently correlated with cardiovascular prognosis, and higher Hb fluctuation was still a protective factor for cardiovascular‐related death in the Hb‐substandard group, but there was no significant correlation between Hb fluctuation and all‐cause death. Multivariate linear regression analysis revealed that Hb fluctuation was positively correlated with Kt/V and EPO dosage, but negatively correlated with the baseline Hb.ConclusionHigh Hb fluctuation was a protective factor for cardiovascular‐related death in PD with substandard Hb. Compared with Hb fluctuation, correction of anemia timely and making Hb reaches the standard level had a greater impact on reducing cardiovascular‐related death in PD.     

Self-assembled sonogels formed from 1,4-naphthalenedicarbonyldinicotinic acid hydrazide

In this paper, we report self-assembled sonogels formed from 1,4-naphthalenedicarbonyldinicotinic acid hydrazide (NDC-NN3) in some liquids including ethanol, tetrahydrofuran (THF), 1,4-dioxane, n-propanol, n-butanol and n-pentanol. When the clear solution of NDC-NN3 in the selected liquids mentioned above at a suitable concentration was irradiated with ultrasound waves at room temperature, a sonogel was formed. Upon heating, the sonogel dissolved gradually and finally became a clear solution again. Upon cooling the hot solution to room temperature, the solution state did not change even after standing for a few days. Nevertheless, if the solution underwent sonication for a certain time, a stable gel was obtained again. The critical gelation concentrations (CGCs) of NDC-NN3 in ethanol, THF, 1,4-dioxane, n-propanol, n-butanol and n-pentanol are 10, 8, 6, 8, 6 and 8 mg mL⁻¹, respectively. The obtained sonogels display excellent mechanical properties. The crystal structure of NDC-NN3 suggests that the naphthalene ring, hydrazide group and the position of N in the pyridine ring mediate the self-assembly process. Upon sonication, the formation of suitable π–π stacking and intermolecular hydrogen bonding drives the gelator molecules to self-assemble into fibers, spheres and micro-burdock-shaped balls in various solvents, which ultimately confine the liquids.

Ultrasound-induced gelation of a novel type of gelator, 1,4-naphthalenedicarbonyl- dinicotinic acid hydrazide, is reported. The gelator self-assembled into various architectures in different solvents.     

Effect of concentration of glycidol on the properties of resorcinol-formaldehyde aerogels and carbon aerogels

By using glycidol as a catalyst, high porosity, low-density resorcinol (R) and formaldehyde (F) aerogels and carbon aerogels (CAs) were synthesized via a sol-gel method. The effect of glycidol and water on the color, density, morphology, textual characteristics and adsorption properties of the resultant RF aerogels and CAs were investigated in detail. The results revealed that the properties of RF aerogels and CAs can be controlled by adjusting the amount of glycidol and water. The resultant RF aerogels and CAs were porous materials, the minimum densities of RF aerogels and CAs were 96 and 110 mg cm⁻³ respectively while the maximum specific surface areas of RF aerogels and CAs were 290 and 597 m² g⁻¹. The maximum adsorption capacity of CAs was about 125 mg g⁻¹ on Rhodamine B, which was higher than that of some reported CAs catalyzed by base and acid catalysts. The sol-gel mechanisms of RF aerogels and CAs can be attributed to the opening of the epoxy group of glycidol in the mixture of R and F.

The sol-gel mechanism of glycidol-catalyzed RF aerogels is the opening of the epoxy ring rather than the preservation the of epoxy ring.     

2型糖尿病男性患者血清骨膜蛋白水平与骨质疏松的相关性研究

目的 探索骨膜蛋白水平2型糖尿病男性患者骨质疏松的关系.方法 收集了2016年3月至2017年3月在我院门诊诊断为2型糖尿病男性病人90例,体检中心健康男性人群中随机选取30例作为正常对照组,记录患者的年龄、腹围、身高、体重,计算BMI,测定甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、糖化血红蛋白,血清骨膜蛋白水平...     

GO/iron series systems enhancing the pH shock resistance of anaerobic systems for sulfate-containing organic wastewater treatment

In this study, the effect of pH shock during the treatment of sulfate-containing organic wastewater was investigated using an anaerobic fermentation system reinforced with graphene oxide (GO)/iron series systems. The results show that the anaerobic system with the GO/iron series systems exhibited enhanced resistance to pH shock. Among them, the GO/Fe⁰ system had the strongest resistance to pH shock, the systems of GO/Fe₃O₄ and GO/Fe₂O₃ followed close behind, while the blank system performed the worst. After pH shock, the COD_Cr removal rate, SO₄²⁻ removal rate, and gas production of the GO/Fe⁰ group were significantly improved compared with those of the control group by 51.0%, 65.3%, and 34.6%, respectively, while the accumulation of propionic acid was the lowest. Further, detailed microbial characterization revealed that the introduction of the GO/iron series systems was beneficial to the formation of more stable anaerobic co-metabolic flora in the system, and the relative abundance of Geobacter, Clostridium, Desulfobulbus and Desulfovibrio increased after acidic and alkaline shock.

In this paper, we studied the pH shock resistance mechanism of GO/iron series from the perspectives of the treatment effect, changes in effluent pH and VFA, and microbial co-metabolic stability, providing a reference for the practical application.     

Preparation of N/O co-doped porous carbon by a one-step activation method for supercapacitor electrode materials

Heteroatom-doped carbon materials used in supercapacitors are low in cost and demonstrate extraordinary performance. Here, ethylenediamine tetraacetic acid (EDTA) with intrinsic N and O elements is selected as a raw material for the preparation of heteroatom self-doped porous carbon. Furthermore, N/O self-doped porous carbon with a large surface area has been successfully prepared using K₂CO₃ as the activator. The derived sample with a 1 : 2 molar ratio of EDTA to K₂CO₃ (EK-2) demonstrates a porous structure, rich defects, a large surface area of 2057 m² g⁻¹ and a micropore volume of 0.25 cm³ g⁻¹. Benefiting from high N content (2.89 at%) and O content (10.75 at%), EK-2 exhibits superior performance, including high capacitance of 325 F g⁻¹ at 1 A g⁻¹ and outstanding cycling stability with 96.8% retention after 8000 cycles at 10 A g⁻¹, which strongly confirms its immense potential toward many applications. Additionally, the maximum energy density of EK-2 reaches was 17.01 W h kg⁻¹ at a power density of 350 W kg⁻¹ in a two-electrode system. This facile and versatile strategy provides a scalable approach for the batch synthesis of N/O co-doped carbonaceous electrode materials for energy storage.

Heteroatom-doped carbon materials used in supercapacitors are low in cost and demonstrate extraordinary performance.     

Trappin-2对HaCaT细胞及银屑病跨膜模型增殖的抑制作用

目的 构建Trappin-2的真核表达体系,初步探讨Trappin-2对HaCaT细胞及银屑病跨膜模型增殖的影响.方法 采用DNA重组技术构建Trappin-2的表达载体pIRES2-EGFP-Trappin-2,通过脂质体法转染入宫颈癌HeLa细胞.将Trappin-2高表达上清加入HaCaT细胞及银屑病跨膜模型中,通过3H-TdR掺入法、MTT法、流式细胞术及组化染色Ki67检测对增殖的影响.结果 Trappin-2作用后MTY和cpm值变化率显示Trappin-2可抑制HaCaT细胞的代谢与DNA合成,同时可使HaCaT细胞G2 S期细胞比例下降,而G1期细胞比例增加.Trappin-2可下调银屑病皮损Ki67表达水平.结论 成功将Trappin-2基因转染HeLa细胞,并进行有效表达,初步证实Trappin-2具有抑制HaCaT细胞及银屑病跨膜模型增殖的特性.     

Assessment of neutrophil to lymphocyte ratio,C-reactive protein,mean platelet volume in obese,and nonobese patients with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is associated with low-grade chronic inflammation.This was a retrospective case–control study.In the present study, the risk coefficients of neutrophil to lymphocyte ratio (NLR), high-sensitive C-reactive protein (hs-CRP), and mean platelet volume (MPV) in obese patients with PCOS were determined. This study was designed to investigate NLR, hs-CRP, and MPV levels in 68 obese patients with PCOS and 44 nonobese patients with PCOS, and our study group was matched with 47 obese and 43 nonobese controls, respectively.PCOS group had higher MPV, NLR, insulin, glucose, and HOMA-IR rates than those of the controls. Subgroup analyses revealed that the obese PCOS group had higher NLR, hs-CRP, and MPV levels compared to those of controls. The obese PCOS group had higher NLR, hs-CRP, and MPV levels compared to those of the nonobese PCOS group. The odds ratios and 95% confidence intervals of those variables (NLR, hs-CRP, MPV) were found significant (P < .05). NLR, hs-CRP, and MPV variables were found statistically significant in the analysis of receiver operating characteristics.Our study demonstrated that NLR, hs-CRP, and MPV levels are increased in patients with obese PCOS.