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971.
Lisa M. Rooper Lester D. R. Thompson Jeffrey Gagan Bahram R. Oliai Ilan Weinreb Justin A. Bishop 《Head and neck pathology》2021,15(1):179
Intraductal carcinoma (IDC) is a rare salivary gland tumor that is considered analogous to ductal carcinoma in-situ of the breast, demonstrating a complex neoplastic epithelial proliferation surrounded by a continuous layer of presumed non-neoplastic myoepithelial cells. It is subcategorized into intercalated duct, apocrine, and hybrid subtypes based on morphologic and immunohistochemical features, with frequent NCOA4-RET and TRIM27-RET fusions, respectively, seen in intercalated duct and hybrid tumors. However, as an expanding clinicopathologic spectrum of IDC has been documented, controversy has emerged as to whether this tumor type is best defined by its intraductal growth pattern or distinctive molecular and immunophenotypic differentiation. Here, we further explore the nature of IDC by evaluating four cases that arose within intraparotid lymph nodes. These intercalated-duct phenotype tumors with diffuse S100 protein expression demonstrated a crowded and complex epithelial proliferation arranged in cystic, cribriform, and micropapillary architecture, surrounded by an intact myoepithelial cell layer, and were completely intranodal. Of two tumors with tissue available for molecular analysis, one demonstrated a NCOA4-RET fusion and one harbored a STRN-ALK fusion that is novel to IDC. Not only does the intranodal presence of IDC present a challenging differential diagnosis, but the complex nature of this proliferation within lymph node tissue raises questions as to whether the myoepithelial component of IDC is actually non-neoplastic in nature. Furthermore, identification of a STRN-ALK fusion expands the genetic spectrum of IDC and adds to evidence of an emerging role for ALK in salivary gland tumors. Further attention to the nature of the myoepithelial cells and documentation of alternate fusion events in IDC may inform continued discussion about its appropriate classification. 相似文献
972.
Chandler Cristian J. Meunier Étienne Eaton Lisa A. Andrade Elí Bukowski Leigh A. Matthews Derrick D. Raymond Henry F. Stall Ronald D. Friedman M. Reuel 《Archives of sexual behavior》2021,50(4):1627-1640
Archives of Sexual Behavior - Black men who have sex with men (MSM) engaged in sex work (BMSM-SW) experience elevated HIV and sexually transmitted infection (STI) prevalence. Further, BMSM-SW have... 相似文献
973.
Zimmermann Hanne M. L. Postma Lisa R. Achterbergh Roel C. A. Reyniers Thijs Schim van der Loeff Maarten F. Prins Maria de Vries Henry J. C. Hoornenborg Elske Davidovich Udi 《Archives of sexual behavior》2021,50(4):1829-1841
Archives of Sexual Behavior - Pre-exposure prophylaxis (PrEP) is a promising strategy to reduce HIV incidence among men who have sex with men (MSM). How and when PrEP is used could in part be... 相似文献
974.
Layland Eric K. Ram Nilam Caldwell Linda L. Smith Edward A. Wegner Lisa 《Archives of sexual behavior》2021,50(6):2383-2394
Archives of Sexual Behavior - Sex during adolescence is normative; however, there are substantial individual differences in the timing and context of sexual debut. Leisure boredom is an... 相似文献
975.
Patrick S. Powell Karen Pazol Lisa D. Wiggins Julie L. Daniels Gabriel S. Dichter Chyrise B. Bradley Rebecca Pretzel Joy Kloetzer Charmaine McKenzie Alexys Scott Britney Robinson Amy S. Sims Eric P. Kasten M. Daniele Fallin Susan E. Levy Patricia M. Dietz Mary E. Cogswell 《MMWR. Morbidity and mortality weekly report》2021,70(17):605
976.
Lisa S. Barsties Leonie A. Daalderop Jacqueline Lagendijk Frank van Steenbergen Jasper V. Been Loes C.M. Bertens Adja J.M. Waelput Hanneke van Zoest Derk Loorbach Eric A.P. Steegers 《Health policy (Amsterdam, Netherlands)》2021,125(3):385-392
BackgroundHealth inequities are already present at birth and affect individuals’ health and socioeconomic outcomes across the life course. Addressing these inequities requires a cross-sectoral approach, covering the first 1,000 days of life. We believe that - in the Dutch context - municipal governments can be the main responsible actor to drive such an approach, since they are primarily responsible for organising adequate public health. Therefore, we aim to identify and develop transformative change towards the implementation of perinatal health into municipal approaches and policies concerning health inequities.MethodsA transition analysis will be combined with action research in six Dutch municipalities. Interviews and interactive group sessions with professionals and organisations that are relevant for the institutional embedding of perinatal health into approaches and policies regarding health inequities, will be organised in each municipality. As a follow-up, a questionnaire will be administered among all participants one year after completion of the group sessions.DiscussionWe expect to gain insights into the role of municipalities in addressing perinatal health inequities, learn more about the interaction between different key stakeholders, and identify barriers and facilitators for a cross-sectoral approach to perinatal health. This knowledge will serve to inform the development of approaches to perinatal health inequities in areas with relatively poor perinatal health outcomes, both in the Netherlands and abroad. 相似文献
977.
Santella Anthony J. Parish Carrigan Dan Rui Feaster Daniel J. Rodriguez Allan E. del Rio Carlos Armstrong Wendy S. Jacobs Petra Metsch Lisa R. 《Journal of community health》2021,46(3):557-564
Journal of Community Health - People living with HIV (PLWH) who use drugs experience worse health outcomes than their non-using counterparts. Little is known about how often they seek dental care... 相似文献
978.
Williams Weston Krueger Amy Wang Guoshen Patel Deesha Belcher Lisa 《Journal of community health》2021,46(4):832-841
Journal of Community Health - Understanding the contribution of CDC-funded testing toward diagnosing HIV informs efforts to end the HIV epidemic. Due to differences in surveillance data and CDC... 相似文献
979.
980.