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91.
B. Fuentes S. Amaro M. Alonso de Leciñana J.F. Arenillas O. Ayo-Martín M. Castellanos M. Freijo A. García-Pastor M. Gomis M. Gómez Choco E. López-Cancio P. Martínez Sánchez A. Morales E.J. Palacio-Portilla M. Rodríguez-Yáñez J. Roquer T. Segura J. Serena J. Vivancos-Mora 《Neurología (Barcelona, Spain)》2021,36(4):305-323
ObjectiveTo update the Spanish Society of Neurology's guidelines for stroke prevention in patients with type 2 diabetes or prediabetes, analysing the available evidence on the effect of metabolic control and the potential benefit of antidiabetic drugs with known vascular benefits in addition to conventional antidiabetic treatments in stroke prevention.DevelopmentPICO-type questions (Patient, Intervention, Comparison, Outcome) were developed to identify practical issues in the management of stroke patients and to establish specific recommendations for each of them. Subsequently, we conducted systematic reviews of the PubMed database and selected those randomised clinical trials evaluating stroke as an independent variable (primary or secondary). Finally, for each of the PICO questions we developed a meta-analysis to support the final recommendations.ConclusionsWhile there is no evidence that metabolic control reduces the risk of stroke, some families of antidiabetic drugs with vascular benefits have been shown to reduce these effects when added to conventional treatments, both in the field of primary prevention in patients presenting type 2 diabetes and high vascular risk or established atherosclerosis (GLP-1 agonists) and in secondary stroke prevention in patients with type 2 diabetes or prediabetes (pioglitazone). 相似文献
92.
Juan David Farfán-Albarracín Cristina Lorena Ramírez-Sierra Oscar Mauricio Espitia Segura Sofy Helena Pérez Hugo Andrés Téllez Prada María Camila Rueda Rodríguez Ingrid Lemus Espitia Ana Maritza Bedoya 《Brain & development》2021,43(1):63-68
IntroductionThe ratio of cerebrospinal fluid (CSF) glucose and blood glucose is of major relevance, conducting to the diagnosis of hypoglycorrhachia, which is a sign of neuroinfection, as well as a number of neurological diseases of genetic or neoplastic etiology. Glucose in capillary sample (glucometry) is a low cost, readily available technique, as compared to venous glucose. This study aims to compare glucometry to venous glucose in the diagnosis of hypoglycorrhachia in pediatric population.MethodsProspective cross-sectional study based on data obtained from lumbar punctures in the period from February 2017 to January 2019 in a specialized pediatric institution in Colombia.Results97 patients were analyzed, aged 1 month to 17 years old, mean 7.67 years, 52 (53.61%) were female. 26 (26.8%) were diagnosed with hypoglycorrhachia. Pearson correlation coefficient for absolute venous and capillary glucose was 0.54, and 0.55 for the ratios of CSF glucose/venous glucose and CSF glucose/glucometry, which support a linear correlation between the variables in both, absolute values and ratios. Intraclass correlation coefficient was calculated for both, the venous glucose and glucometry ratios, which was 0.52, revealing a moderate agreement among the tests. Sensitivity and specificity of CSF glucose/glucometry, as compared to gold standard are 73.1% and 60.6% respectively; whereas predictive positive value (PPV) and negative predictive value (NPV), were 40.4% and 86.0%.ConclusionGlucometry cannot replace the glucose in venous sample in the diagnosis of hypoglycorrhachia in children. 相似文献
93.
Michael Feyder PhD Carina Plewnia BSc Ori J. Lieberman BSc Giada Spigolon PhD Alessandro Piccin PhD Lidia Urbina BSc Benjamin Dehay PhD Qin Li PhD Per Nilsson PhD Mikael Altun PhD Emanuela Santini PhD David Sulzer PhD Erwan Bezard PhD Anders Borgkvist PhD Gilberto Fisone PhD 《Movement disorders》2021,36(5):1137-1146
94.
Delfino Cecilia María Giorgio Marianela García Gabriela Puch Silvia Sánchez Outon Estela Mathet Verónica Lidia 《Virus genes》2021,57(4):327-337
Virus Genes - Argentina exhibits low serological prevalence for Hepatitis B virus (HBV); however, occult hepatitis B infection (OBI) has been reported in blood donors, Amerindians and individuals... 相似文献
95.
Castano-Jaramillo Lina M. Yamazaki-Nakashimada Marco Antonio O’Farrill-Romanillos Patricia M. Muzquiz Zermeño David Scheffler Mendoza Selma C. Venegas Montoya Edna García Campos Jorge Alberto Sánchez-Sánchez Luz María Gámez González Luisa B. Ramírez López Jesús Moisés Bustamante Ogando Juan Carlos Vásquez-Echeverri Estefanía Medina Torres Edgar Alejandro Lopez-Herrera Gabriela Blancas Galicia Lizbeth Berrón Ruiz Laura Staines-Boone Aidé Tamara Espinosa-Padilla Sara Elva Segura Mendez Nora Hilda Lugo Reyes Saul O. 《Journal of clinical immunology》2021,41(7):1463-1478
Journal of Clinical Immunology - Patients with inborn errors of immunity (IEI) have a compromised or inappropriate immune response. Although they might be considered a high-risk group for severe... 相似文献
96.
Bobillo-Perez Sara Cuaresma Adriana Girona-Alarcon Monica Sole-Ribalta Anna Cañizo Debora Cambra Francisco Jose Jordan Iolanda Segura Susana Pertierra Africa 《Journal of artificial organs》2021,24(4):507-510
Journal of Artificial Organs - The precise moment for weaning a patient off extracorporeal membrane oxygenation (ECMO) is not always easy to establish. Also, mechanical causes may obligate to... 相似文献
97.
C. Manzardo A. Esteve N. Ortega D. Podzamczer J. Murillas F. Segura L. Force C. Tural J. Vilaró A. Masabeu I. Garcia M. Guadarrama E. Ferrer M. Riera G. Navarro B. Clotet J.M. Gatell J. Casabona J.M. Miró 《Clinical microbiology and infection》2013,19(7):646-653
In this prospective, multicentre cohort study, we analysed specific prognostic factors and the impact of timing of highly active antiretroviral therapy (HAART) on disease progression and death among 625 human immunodeficiency virus (HIV)-1-infected, treatment-naïve patients diagnosed with an AIDS-defining disease. HAART was classified as early (<30 days) or late (30–270 days). Deferring HAART was significantly associated with faster progression to a new AIDS-defining event/death overall (p 0.009) and in patients with Pneumocystis jiroveci pneumonia (p 0.017). In the multivariate analysis, deferring HAART was associated with a higher risk of a new AIDS-defining event/death (p 0.002; hazard ratio 1.83; 95% CI 1.25–2.68). Other independent risk factors for poorer outcome were baseline diagnosis of AIDS-defining lymphoma, age >35 years, and low CD4+ count (<50 cells/μL). 相似文献
98.
99.
J. G. Pallarés Á. López‐Samanes V. E. Fernández‐Elías R. Aguado‐Jiménez J. F. Ortega C. Gómez R. Ventura J. Segura R. Mora‐Rodríguez 《Scandinavian journal of medicine & science in sports》2015,25(6):e603-e612
This study analyzed the effects of pseudoephedrine (PSE) provided at different time of day on neuromuscular performance, side effects, and violation of the current doping cut‐off threshold [World Anti‐Doping Agency (WADA)]. Nine resistance‐trained males carried out bench press and full squat exercises against four incremental loads (25%, 50%, 75%, and 90% one repetition maximum [1RM]), in a randomized, double‐blind, cross‐over design. Participants ingested either 180 mg of PSE (supra‐therapeutic dose) or placebo in the morning (7:00 h; AMPLAC and AMPSE) and in the afternoon (17:00 h; PMPLAC and PMPSE). PSE enhanced muscle contraction velocity against 25% and 50% 1RM loads, only when it was ingested in the mornings, and only in the full squat exercise (4.4–8.7%; P < 0.05). PSE ingestion raised urine and plasma PSE concentrations (P < 0.05) regardless of time of day; however, cathine only increased in the urine samples. PSE ingestion resulted in positive tests occurring in 11% of samples, and it rose some adverse side effects such us tachycardia and heart palpitations. Ingestion of a single dose of 180 mg of PSE results in enhanced lower body muscle contraction velocity against low and moderate loads only in the mornings. These mild performance improvements are accompanied by undesirable side effects and an 11% risk of surpassing the doping threshold. 相似文献
100.
Izabela Szczygielska El?bieta Hernik Ma?gorzata Kwiatkowska Lidia Rutkowska-Sak Beata Ko?odziejczyk Agnieszka Gazda 《Reumatologia》2015,53(2):56-60