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101.
The interaction effect between BDNF val66met polymorphism and obesity on executive functions and frontal structure 下载免费PDF全文
Idoia Marqués‐Iturria Maite Garolera Roser Pueyo Bàrbara Segura Imma Hernan Isabel García‐García Consuelo Sánchez‐Garre María Vernet‐Vernet María José Sender‐Palacios Ana Narberhaus Mar Ariza Carme Junqué María Ángeles Jurado 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2014,165(3):245-253
102.
Liliana Muschietti Virginia Martino Graciela Ferraro Jorge Coussio Laura Segura Carmen Carta Salvador Caigueral Toms Adzet 《Phytotherapy research : PTR》1996,10(1):84-86
Extracts (aqueous, methanol and dichloromethane) from Ambrosia tenuifolia, Aristolochia triangularis, Baccharis tucumanensis, Campyloneuron phyllitidis and Eupatorium christieanum were screened for antiinflammatory activity. On the croton oil induced mouse ear oedema test, the highest activities were exhibited by dichloromethane extracts assayed, especially those of Baccharis tucumanensis and Campyloneuron phyllitidis. On the carrageenan mouse paw oedema test, Baccharis tucumanensis and Campyloneuron phyllitidis showed the highest activity. 相似文献
103.
Otilia Perichart-Perera Jennifer Mier-Cabrera Claudia Montserrat Flores-Robles Nayeli Martínez-Cruz Lidia Arce-Snchez Itzel Nallely Alvarado-Maldonado Araceli Montoya-Estrada Jos Romo-Yaez Ameyalli Mariana Rodríguez-Cano Guadalupe Estrada-Gutierrez Salvador Espino y Sosa Mario Guzmn-Huerta Rodrigo Ayala-Yaez Enrique Reyes-Muoz 《Nutrients》2022,14(1)
The aim of this study was to examine the efficacy of intensive medical nutrition therapy (MNT) plus metformin in preventing gestational diabetes mellitus (GDM) among high-risk Mexican women. An open-label randomized clinical trial was conducted. Inclusion criteria were pregnant women with three or more GDM risk factors: Latino ethnic group, maternal age >35 years, body mass index >25 kg/m2, insulin resistance, and a history of previous GDM, prediabetes, a macrosomic neonate, polycystic ovarian syndrome, or a first-degree relative with type 2 diabetes. Women before 15 weeks of gestation were assigned to group 1 (n = 45): intensive MNT-plus metformin (850 mg twice/day) or group 2 (n = 45): intensive MNT without metformin. Intensive MNT included individual dietary counseling, with ≤50% of total energy from high carbohydrates. The primary outcome was the GDM incidence according to the International Association of Diabetes Pregnancy Study Groups criteria. There were no significant differences in baseline characteristics and adverse perinatal outcomes between the groups. The GDM incidence was n = 11 (24.4%) in the MNT plus metformin group versus n = 7 (15.5%) in the MNT without metformin group: p = 0.42 (RR: 1.57 [95% CI: 0.67–3.68]). There is no benefit in adding metformin to intensive MNT to prevent GDM among high-risk Mexican women. Clinical trials registration: . NCT01675310相似文献
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Bahare Salehi Dmitry A. Konovalov Pascaline Fru Petrina Kapewangolo Gregorio Peron Mileski S. Ksenija Susana M. Cardoso Olivia R. Pereira Manisha Nigam Silvana Nicola Giuseppe Pignata Simona Rapposelli Simona Sestito Nanjangud V. Anil Kumar María de la Luz Cdiz‐Gurrea Antonio Segura‐Carretero Abhay P. Mishra Mehdi Sharifi‐Rad William C. Cho Yasaman Taheri William N. Setzer Javad Sharifi‐Rad 《Phytotherapy research : PTR》2020,34(9):2140-2158
The family Arecaceae includes 181 genera and 2,600 species with a high diversity in physical characteristics. Areca plants, commonly palms, which are able to grow in nearly every type of habitat, prefer tropical and subtropical climates. The most studied species Areca catechu L. contains phytochemicals as phenolics and alkaloids with biological properties. The phenolics are mainly distributed in roots followed by fresh unripe fruits, leaves, spikes, and veins, while the contents of alkaloids are in the order of roots, fresh unripe fruits, spikes, leaves, and veins. This species has been reputed to provide health effects on the cardiovascular, respiratory, nervous, metabolic, gastrointestinal, and reproductive systems. However, in many developing countries, quid from this species has been associated with side effects, which include the destruction of the teeth, impairment of oral hygiene, bronchial asthma, or oral cancer. Despite these side effects, which are also mentioned in this work, the present review collects the main results of biological properties of the phytochemicals in A. catechu. This study emphasizes the in vitro and in vivo antioxidant, antimicrobial, anticancer, and clinical effectiveness in humans. In this sense, A. catechu have demonstrated effectiveness in several reports through in vitro and in vivo experiments on disorders such as antimicrobial, antioxidant, or anticancer. Moreover, our findings demonstrate that this species presents clinical effectiveness on neurological disorders. Hence, A. catechu extracts could be used as a bioactive ingredient for functional food, nutraceuticals, or cosmeceuticals. However, further studies, especially extensive and comprehensive clinical trials, are recommended for the use of Areca in the treatment of diseases. 相似文献
106.
Rebeca Libana-García Marta Olivares Sonia M. Rodríguez-Ruano Vernica Tolosa-Enguís Isabel Chulia Lidia Gil-Martínez Enrique Guillamn Alberto Baos Yolanda Sanz 《Nutrients》2022,14(3)
Allium species and their organosulfur-derived compounds could prevent obesity and metabolic dysfunction, as they exhibit immunomodulatory and antimicrobial properties. Here, we report the anti-obesogenic potential and dose-dependent effects (0.1 or 1 mg/kg/day) of propyl propane thiosulfinate (PTS) in a murine model of diet-induced obesity. The obesogenic diet increased body weight gain and adipocyte size, and boosted inflammatory marker (Cd11c) expression in the adipose tissue. Conversely, PTS prevented these effects in a dose-dependent manner. Moreover, the higher dose of PTS improved glucose and hepatic homeostasis, modulated lipid metabolism, and raised markers of the thermogenic capacity of brown adipose tissue. In the colon, the obesogenic diet reduced IL-22 levels and increased gut barrier function markers (Cldn3, Muc2, Reg3g, DefaA); however, the highest PTS dose normalized all of these markers to the levels of mice fed a standard diet. Gut microbiota analyses revealed no differences in diversity indexes and only minor taxonomic changes, such as an increase in butyrate producers, Intestimonas and Alistipes, and a decrease in Bifidobacterium in mice receiving the highest PTS dose. In summary, our study provides preclinical evidence for the protective effects of PTS against obesity, which if confirmed in humans, might provide a novel plant-based dietary product to counteract this condition. 相似文献
107.
Muhammad Saaiq Iris Zalaudek Babar Rao Young Lee Lidia Rudnicka Joanna Czuwara Roberta Giuffrida Uwe Wollina Mohammad Jafferany Torello Lotti Stephan Grabbe Mohamad Goldust 《Dermatologic therapy》2020,33(4)
Melanoma constitutes one of the most sinister and troublesome malignancies encountered by humanity. Generally, the diagnosis of advanced melanoma connotes a grave prognosis, prompting a sense of looming threat of death, however, the early‐stage detected disease responds well to robust treatment resulting in reasonable survivorship. Scalp melanomas are even more troublesome, because they typically exhibit more aggressive biologic behavior and are often diagnosed at a late stage. This review tries to comprehensively highlight the various diagnostic, therapeutic, and outcome aspects of scalp melanomas. The literature research includes peer‐reviewed articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) till May 2020 and reference lists of respective articles. Only articles published in English language were included. 相似文献
108.
Rachita Dhurat Aseem Sharma Lidia Rudnicka George Kroumpouzos Martin Kassir Hassan Galadari Uwe Wollina Torello Lotti Masa Golubovic Iva Binic Stephan Grabbe Mohamad Goldust 《Dermatologic therapy》2020,33(3)
Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5‐alpha reductase (5‐AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5‐alpha reductase inhibitor (5‐ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity. 相似文献
109.
110.
Oscar Hidalgo‐Lanussa Eliana Baez‐Jurado Valentina Echeverria Ghulam Md Ashraf Amirhossein Sahebkar Luis Miguel Garcia‐Segura Roberto C. Melcangi George E. Barreto 《Journal of neuroendocrinology》2020,32(1)
The high concentrations of free fatty acids as a consequence of obesity and being overweight have become risk factors for the development of different diseases, including neurodegenerative ailments. Free fatty acids are strongly related to inflammatory events, causing cellular and tissue alterations in the brain, including cell death, deficits in neurogenesis and gliogenesis, and cognitive decline. It has been reported that people with a high body mass index have a higher risk of suffering from Alzheimer's disease. Hormones such as oestradiol not only have beneficial effects on brain tissue, but also exert some adverse effects on peripheral tissues, including the ovary and breast. For this reason, some studies have evaluated the protective effect of oestrogen receptor (ER) agonists with more specific tissue activities, such as the neuroactive steroid tibolone. Activation of ERs positively affects the expression of pro‐survival factors and cell signalling pathways, thus promoting cell survival. This review aims to discuss the relationship between lipotoxicity and the development of neurodegenerative diseases. We also elaborate on the cellular and molecular mechanisms involved in neuroprotection induced by oestrogens. 相似文献