Unusual morphologic features of low‐grade endometrial stromal sarcoma: A case report

BackgroundEndometrial stromal tumours are uncommon tumours of the uterus. They mainly occur in perimenopausal women. Tumours with typical clinicopathological features do not usually pose diagnostic problems. However, rare clinicopathological features can occur, and clinicians without significant experience may have difficulty diagnosing these tumours and managing these patients.MethodsHerein, we report a case of endometrial stromal sarcoma that occurred in a 25‐year‐old woman. The pathological features, immunophenotype, treatment and prognosis were discussed.ResultsThe tumour revealed morphological heterogeneity, and there were similar proliferative‐type endometrial stromal cells, an extensive amount of mature adipose tissue, and prominent rhabdomyoblastic and smooth muscle cells. Histopathological and immunohistochemical studies confirmed low‐grade endometrial stromal sarcoma with smooth muscle, adipocytic and rhabdomyoblastic differentiation (approximately 60% were differentiated tissues). The final treatment of the tumour was total abdominal hysterectomy with bilateral salpingo‐oophorectomy. There was no evidence of recurrence for 109 months postoperatively.ConclusionsWe found that low‐grade endometrial stromal tumours with extensive adipocytic and prominent rhabdomyoblastic differentiation are misdiagnosed because they are infrequent. They must be differentiated from rhabdomyosarcoma with accurate identification of adipocytes, and long‐term follow‐up is needed.     

The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation

ObjectiveTo explore the influence of apolipoprotein E (APOE) genotypes and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation (AF).MethodsPatients with suspected CAD were consecutively enrolled and divided into groups with or without CAD and/or AF. Blood lipid levels and APOE genotypes were determined and analysed for associations with CAD and AF.ResultsA total of 2048 patients were included (400 patients without CAD or AF [controls], 126 patients without CAD but with AF, 1294 patients with CAD without AF, and 228 patients with CAD and AF). Age and lipoprotein (a) (Lp[a]) levels were significantly higher in patients with CAD and AF versus those with CAD without AF. Among patients with CAD, the E3/E3 genotype and ε3 allele frequencies were significantly lower in patients with AF than in those without AF, and the E4/E4 genotype and ε4 allele frequencies were significantly increased. Multivariate logistic regression revealed that increased Lp(a) levels and age were independent risk factors for AF in patients with CAD.ConclusionAmong patients with CAD, those with AF had increased age, ε4 frequencies and Lp(a) levels. Age and Lp(a) levels may be independent risk factors for AF in patients with CAD.     

注射用奥沙利铂对比奥沙利铂脂质体Beagle犬的解剖病理学评价

目的:比较注射用奥沙利铂和奥沙利铂脂质体对Beagle犬毒性作用的解剖病理学改变,为抗癌药物脂质体制剂的临床前安全性评价提供重要的形态学参考数据。方法:Beagle犬分为阴性对照组、空载体脂质体组、注射用奥沙利铂组、奥沙利铂脂质体低、高剂量组。静脉滴注每2周给药1次,共4次,恢复期1个月。解剖动物进行组织病理学检查。结果:与脂质体、注射用奥沙利铂和奥沙利铂脂质体相关的组织病理学变化分别为多组织器官的泡沫细胞聚集;睾丸生精细胞数量减少,附睾精子减少症和胸腺、脾脏萎缩;肝脏小肉芽肿,胸腺、脾脏萎缩。结论:通过以上同一抗癌药物不同剂型对Beagle犬的解剖病理学评价比较,为抗癌药物脂质体剂型临床前安全性评价提供了重要的形态学参考数据。     

蜂海绵Haliclonasp.化学成分的研究

对采自我罱海的蜂海绵Ｈａｌｉｃｌｏｍａｓｐ．的化学成分进行了研究。结果表明：从Ｈａｌｉｃｌｏｎａｓｐ．中分离出２个结晶性化合物１和２。应用波谱分析和元素分析鉴定１和２的结构分别为１，３－二甲基黄嘌呤和对羟基苯甲酸。这是从海绵中分离出上述化合物的首次报道。     

内生真菌SEF15927对截短侧耳素的微生物羟化研究

目的 研究植物内生真菌SEF15927对截短侧耳素的转化作用.方法 利用液体培养生长细胞对截短侧耳素进行生物转化.发酵液经乙酸乙酯萃取和硅胶柱层析分离获得一个羟化产物.运用质谱和核磁共振光谱鉴定结构.结果 转化产物为2-羟基截短侧耳素.结论 植物内生真菌SEF15927为一具有高转化率的截短侧耳素羟化菌株,     

焦谷氨酸油醇酯促进药物经皮吸收活性的研究及其合成

用谷氨酸和油醇合成焦谷氨酸油醇酯。在该化合物作用下替硝唑、咖啡因和 醋酸可的松经皮渗透分别增大了41．8、9．1和2．9倍。     

大鼠肠道菌群对长梗冬青苷体外代谢的影响

摘 要 目的：探究体外孵育的大鼠肠道菌群对长梗冬青苷的代谢转化规律。方法: 将长梗冬青苷与大鼠肠道菌群在厌氧条件下共孵育,分别于0,4,8,12,24,48 h时取样,经乙酸乙酯萃取后采用HPLC法进行定性和定量分析。结果: 在与大鼠肠道菌群共孵育48 h后,90.8%的长梗冬青苷被代谢转化为M₂,M₂与铁冬青酸对照品通过HPLC分析时色谱行为一致,故确定M₂为铁冬青酸。结论:长梗冬青苷可以被体外孵育的大鼠肠道菌群代谢转化为铁冬青酸。     

Biofilm formation and invasive ability contribute to CC17 serotype III group B Streptococcus virulence

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畸变产物耳声发射在唇腭裂婴幼儿听力检查中的应用

目的探讨唇腭裂婴幼儿畸变产物耳声发射（distortion product otoacoustic emission,DPOAE）的特点,并将其与听性脑干反应（auditory brainstem response,ABR）阂值检查的结果加以对照,以探讨DPOAE在这类患儿听力检查中的应用价值。方法DPOAE检查63例（126耳）,年龄2个月-42个月,平均11.83个月。其中单纯腭裂组（以下简称腭裂组）23例（46耳）,腭裂并发唇裂及牙槽裂组（以下简称唇腭裂组）30例（60耳）,单纯唇裂组（以下简称唇裂组）10例（20耳）,每耳均检查8个频率,若2-5kHz4个频点有≥3个频点通过即为该耳通过。在上述患儿中,ABR阈值检查腭裂组17例（34耳）,唇腭裂组10例（20耳）,唇裂组6例（12耳）,以能重复引出V波的最小刺激强度为ABR阈值。结果DPOAE检查：腭裂组通过7耳,未通过39耳,通过率为15.22％;唇腭裂组通过6耳,未通过54耳,通过率为10.00％;唇裂组通过18耳,未通过2耳,通过率为90％。统计分析腭裂组与唇腭裂组无显著差异,而腭裂组与唇裂组,唇腭裂组与唇裂组均有显著差异。ABR阈值检查统计分析结果与DPOAE一致。将各组DPOAE通过率与ABR正常率进行比较,腭裂组及唇腭裂组中二者无差异（P〉0.05）,虽然唇裂组中二者有差异（P〈0.05）,但唇裂组ABR阈值反应的听力下降较轻（均≤50dB nHL）。从总体趋势上说,DPOAE与ABR阈值检查在检测的结果上是一致的。结论唇腭裂患儿DPOAE和ABR检测结果一致,与ABR相比,DPOAE具有快速、简便、易实施等特点,因此DPOAE可以作为唇腭裂婴幼儿听力检查的手段,但仍需进一步结合ABR及其他相关的听力检查,以明确听力损害的程度和类型。     

原发性鼻腔透明细胞癌1例并文献复习

目的:探讨原发性鼻腔透明细胞癌的临床表现及病理特点,总结其诊断及治疗方法。方法:分析1例原发性鼻腔透明细胞癌患者的临床资料,复习1992年以来11例相关文献,做出总结报道。结果:12例原发性鼻腔-鼻窦透明细胞癌中8例(66.7%)主要表现为鼻出血,4例(33.3%)出现骨质破坏;CT显示鼻腔、鼻窦内条片状类似软组织密度影,行单纯手术切除治疗3例(25.0%),手术切除联合放、化疗7例(58.3%),单纯放化疗2例(16.7%)。治疗后随访6个月～10年,仅1例患者因出现肺部转移死亡,余均健在。结论:原发性鼻腔-鼻窦透明细胞癌较罕见,早期症状以鼻出血多见,病理学上需与转移性透明细胞癌及多种含透明细胞的涎腺肿瘤鉴别。治疗以手术切除联合放化疗为主,短期内预后较好。早期局限于鼻腔和鼻窦的有基底的肿瘤可考虑鼻内镜手术,术后建议每半年复查一次。