全文获取类型
收费全文 | 48360篇 |
免费 | 3425篇 |
国内免费 | 201篇 |
专业分类
耳鼻咽喉 | 391篇 |
儿科学 | 1556篇 |
妇产科学 | 1230篇 |
基础医学 | 6758篇 |
口腔科学 | 598篇 |
临床医学 | 5182篇 |
内科学 | 10060篇 |
皮肤病学 | 943篇 |
神经病学 | 5721篇 |
特种医学 | 1161篇 |
外科学 | 4486篇 |
综合类 | 387篇 |
一般理论 | 58篇 |
预防医学 | 5780篇 |
眼科学 | 705篇 |
药学 | 3073篇 |
中国医学 | 88篇 |
肿瘤学 | 3809篇 |
出版年
2024年 | 60篇 |
2023年 | 657篇 |
2022年 | 1099篇 |
2021年 | 2171篇 |
2020年 | 1308篇 |
2019年 | 1811篇 |
2018年 | 2080篇 |
2017年 | 1390篇 |
2016年 | 1548篇 |
2015年 | 1694篇 |
2014年 | 2051篇 |
2013年 | 2693篇 |
2012年 | 4268篇 |
2011年 | 4254篇 |
2010年 | 2174篇 |
2009年 | 1903篇 |
2008年 | 3039篇 |
2007年 | 2993篇 |
2006年 | 2852篇 |
2005年 | 2676篇 |
2004年 | 2352篇 |
2003年 | 2125篇 |
2002年 | 1810篇 |
2001年 | 254篇 |
2000年 | 226篇 |
1999年 | 272篇 |
1998年 | 362篇 |
1997年 | 273篇 |
1996年 | 235篇 |
1995年 | 191篇 |
1994年 | 130篇 |
1993年 | 121篇 |
1992年 | 98篇 |
1991年 | 85篇 |
1990年 | 84篇 |
1989年 | 75篇 |
1988年 | 69篇 |
1987年 | 49篇 |
1986年 | 56篇 |
1985年 | 48篇 |
1984年 | 50篇 |
1983年 | 54篇 |
1982年 | 35篇 |
1981年 | 43篇 |
1980年 | 29篇 |
1979年 | 19篇 |
1978年 | 16篇 |
1977年 | 22篇 |
1976年 | 12篇 |
1973年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
981.
Laura Argiz Sonsoles Infante Adrianna Machinena Teresa Bracamonte Luis Echeverria Ana Prieto Teresa Garriga Leticia Vila Purificación Gonzalez-Delgado Carlos Garcia-Magan Emilio Garcia Iria Carballeira Sonia Vazquez-Cortes Francesca Mori Simona Barni Stefania Arasi Mariona Pascal Robert J. Boyle Marta Vazquez-Ortiz the BIO-FPIES study network 《Clinical and experimental allergy》2021,51(9):1238-1241
982.
Liu Gengbo Mitra Debasis Jones Ella F. Franc Benjamin L. Behr Spencer C. Nguyen Alex Bolouri Marjan S. Wisner Dorota J. Joe Bonnie N. Esserman Laura J. Hylton Nola M. Seo Youngho 《Journal of digital imaging》2021,34(3):630-636
Journal of Digital Imaging - In this proof-of-concept work, we have developed a 3D-CNN architecture that is guided by the tumor mask for classifying several patient-outcomes in breast cancer from... 相似文献
983.
Wu Nan Huang Zhe Shen Yiqiu Park Jungkyu Phang Jason Makino Taro Gene Kim S. Cho Kyunghyun Heacock Laura Moy Linda Geras Krzysztof J. 《Journal of digital imaging》2021,34(6):1414-1423
Journal of Digital Imaging - Breast cancer is the most common cancer in women, and hundreds of thousands of unnecessary biopsies are done around the world at a tremendous cost. It is crucial to... 相似文献
984.
985.
Dennis M. de Graaf Martin Jaeger Inge C. L. van den Munckhof Rob ter Horst Kiki Schraa Jelle Zwaag Matthijs Kox Mayumi Fujita Takeshi Yamauchi Laura Mercurio Stefania Madonna Joost H.W. Rutten Jacqueline de Graaf Niels P. Riksen Frank L. van de Veerdonk Mihai G. Netea Leo A.B. Joosten Charles A. Dinarello 《European journal of immunology》2021,51(3):662-671
The IL-1 family member IL-38 (IL1F10) suppresses inflammatory and autoimmune conditions. Here, we report that plasma concentrations of IL-38 in 288 healthy Europeans correlate positively with circulating memory B cells and plasmablasts. IL-38 correlated negatively with age (p = 0.02) and was stable in 48 subjects for 1 year. In comparison with primary keratinocytes, IL1F10 expression in CD19+ B cells from PBMC was lower, whereas cell-associated IL-38 expression was comparable. In vitro, IL-38 is released from CD19+ B cells after stimulation with rituximab. Intravenous LPS in humans failed to induce circulating IL-38, compared to 100-fold induction of IL-6 and IL-1 receptor antagonist. In a cohort of 296 subjects with body mass index > 27 at high risk for cardiovascular disease, IL-38 plasma concentrations were significantly lower than in healthy subjects (p < 0.0001), and lowest in those with metabolic syndrome (p < 0.05). IL-38 also correlated inversely with high sensitivity C-reactive protein (p < 0.01), IL-6, IL-1Ra, and leptin (p < 0.05). We conclude that a relative deficiency of the B cell product IL-38 is associated with increased systemic inflammation in aging, cardiovascular and metabolic disease, and is consistent with IL-38 as an anti-inflammatory cytokine. 相似文献
986.
Mark Korthals Laura Tech Kristina Langnaese Anna Gottfried Johannes Hradsky Ulrich Thomas Ana Claudia Zenclussen Monika C. Brunner-Weinzierl Kerry Tedford Klaus-Dieter Fischer 《European journal of immunology》2021,51(3):594-602
The amplitude and duration of Ca2+ signaling is crucial for B-cell development and self-tolerance; however, the mechanisms for terminating Ca2+ signals in B cells have not been determined. In lymphocytes, plasma membrane Ca2+ ATPase (PMCA) isoforms 1 and 4 (PMCA1 and PMCA4, aka ATP2B1 and ATP2B4) are the main candidates for expelling Ca2+ from the cell through the plasma membrane. We report here that Pmca4 (Atp2b4) KO mice had normal B-cell development, while mice with a conditional KO of Pmca1 (Atp2b1) had greatly reduced numbers of B cells, particularly splenic follicular B cells, marginal zone B cells, and peritoneal B-1a cells. Mouse and naïve human B cells showed only PMCA1 expression and no PMCA4 by western blot, in contrast to T cells, which did express PMCA4. Calcium handling was normal in Pmca4−/− B cells, but Pmca1 KO B cells had elevated basal levels of Ca2+, elevated levels in ER stores, and reduced Ca2+ clearance. These findings show that the PMCA1 isoform alone is required to ensure normal B-cell Ca2+ signaling and development, which may have implications for therapeutic targeting of PMCAs and Ca2+ in B cells. 相似文献
987.
Ana Marcos-Jiménez Santiago Sánchez-Alonso Ana Alcaraz-Serna Laura Esparcia Celia López-Sanz Miguel Sampedro-Núñez Tamara Mateu-Albero Ildefonso Sánchez-Cerrillo Pedro Martínez-Fleta Ligia Gabrie Luciana del Campo Guerola José Miguel Rodríguez-Frade José M. Casasnovas Hugh T. Reyburn Mar Valés-Gómez Margarita López-Trascasa Enrique Martín-Gayo María José Calzada Santos Castañeda Hortensia de la Fuente Isidoro González-Álvaro Francisco Sánchez-Madrid Cecilia Muñoz-Calleja Arantzazu Alfranca 《European journal of immunology》2021,51(3):634-647
SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients were associated with the severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B, and NK cells is associated with severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56–CD16+ NK-cells increased. Regarding humoral immunity, levels of IgM, IgA, and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless of their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes, and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID-19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention. 相似文献
988.
989.
José María Bermúdez de Castro Mario Modesto-Mata Laura Martín-Francés Cecilia García-Campos Marina Martínez de Pinillos María Martinón-Torres 《Journal of anatomy》2021,238(1):173-184
The Middle Pleistocene Sima de los Huesos (SH) site has yielded more than 7.500 human fossil remains belonging to a minimum of 29 individuals. Most of these individuals preserve either the complete mandibular molar series or at least the first (M1) and second (M2) molars. The inhibitory cascade mathematical model was proposed by Kavanagh et al. (Nature, 449, 427–433 [2007]) after their experimental studies on the dental development of murine rodent species. The activator–inhibitor mechanism of this model has shown its ability for predicting evolutionary size patterns of mammalian teeth, including hominins. The main aim of this study is to test whether the size molar patterns observed in the SH hominins fit the inhibitory cascade model. With this purpose, we have measured the crown area of all SH molars in photographs, using a planimeter and following techniques used and well contrasted in previous works. Following one of the premises of the inhibitory cascade model, we expect that the central tooth (M2 in our case) of a triplet would have the average size of the two outer teeth. The absolute difference between the observed and the expected values for the M2s ranges from 0.23 to 8.46 mm2 in the SH sample. In terms of percentage, the difference ranges between 0.25% and 10.34%, although in most cases, it is below 5%. The plot of the estimated M3/M1 and M2/M1 size ratios obtained in the SH hominins occupies a small area of the theoretical developmental morphospace obtained for rodent species. In addition, the majority of the values are placed near the theoretical line which defines the relationship predicted by the inhibitory cascade model in these mammals. The values of the slope and intercept of the reduced major regression obtained for the SH individuals do not differ significantly from those obtained for rodent species, thus confirming that the size of the molars of the SH hominins fits the inhibitory cascade model. We discuss these results in terms of dental development. Despite the promising results in the SH sample, we draw the attention to the fact that most Early Pleistocene Homo specimens exhibit a pattern (M1 < M2 > M3), which is outside the expected theoretical morphospace predicted by the inhibitory cascade model. The shift from the M1 < M2 < M3 size relationship observed in early hominins (including H. habilis) to the M1 > M2 > M3 size relationship, which is predominant in modern humans, includes sequences that depart from predictions of the inhibitory cascade model. Additional studies are required to understand these deviations. 相似文献
990.