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11.
Charles H Henry Judith A Whittum-Hudson Gregory T Tull Larry M Wolford 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(1):e22-e26
OBJECTIVE: The objective of this study was to determine if temporomandibular joint (TMJ) samples positive for Chlamydia trachomatis have a greater presence of tumor necrosis factor-alpha (TNFalpha) or interleukin-6 (IL-6) when compared with Chlamydia-negative samples. STUDY DESIGN: Posterior bilaminar tissue samples removed during TMJ surgery from 70 patients were evaluated. Cryosections were stained using monoclonal antibody that identifies C. trachomatis. The presence of IL-6 and TNFalpha were evaluated by immunostaining in 15 samples positive and in 25 samples negative for the presence of C. trachomatis. RESULTS: Of the 70 TMJ samples, 32 (46%) were positive for C. trachomatis. In 15 samples positive for C. trachomatis, 10 (67%) were positive for TNFalpha and 7 (47%) for IL-6. In 25 samples negative for C. trachomatis, only 4 (16%) were positive for TNFalpha and only 2 (8%) for IL-6. Differences in C. trachomatis-positive samples versus negative were significant for both TNFalpha (P < .002) and IL-6 (P < .008). CONCLUSION: The presence of C. trachomatis in the TMJ is associated with a significantly increased presence of TNFalpha and IL-6. 相似文献
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Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod. 总被引:2,自引:0,他引:2
David E Spaner Richard L Miller Jenny Mena Larry Grossman Vicki Sorrenti Yonghong Shi 《Leukemia & lymphoma》2005,46(6):935-939
The identification of clinically relevant, active immunomodulatory agents is important for developing immunotherapeutic approaches to chronic lymphocytic leukemia (CLL) and other B-cell lymphomas that are not curable with conventional chemotherapy. In this investigation, the imidazoquinoline Toll-like receptor (TLR)-7/8 agonist, imiquimod, was found to mediate the clearance of a lymphomatous skin lesion in a CLL patient. Imidazoquinolines also activated TLR-7/8 signaling pathways, resulting in increased expression of costimulatory molecules on circulating tumor cells. These observations extend the therapeutic spectrum of imiquimod to cutaneous B-cell lymphomas and suggest the use of TLR-7/8 agonists in CLL immunotherapy. 相似文献
16.
Patrick E. Barta Richard E. Powers Elizabeth H. Aylward Gary A. Chase Gordon J. Harris Peter V. Rabins Larry E. Tune Godfrey D. Pearlson 《Psychiatry Research: Neuroimaging》1997,68(2-3):65-75
Volumes of medial and lateral temporal lobe structures were assessed using magnetic resonance imaging (MRI) in 11 patients with late-life onset schizophrenia (LOS), 18 normal elderly controls and 12 patients with moderate cognitive impairment due to Alzheimer's disease (AD) who had no non-cognitive symptoms. While both patient groups has smaller volumes of several medial temporal regions (e.g. entorhinal cortex, left hippocampus), schizophrenics had significantly smaller anterior superior temporal gyri (STG) than normal controls, but AD patients did not. We have previously demonstrated anterior STG volume to be reduced in early life onset schizophrenia. 相似文献
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Pharmacological interactions between serotonin and dopamine on behavior in the squirrel monkey 总被引:2,自引:1,他引:1
The behavioral effects of GBR 12909, a selective dopamine uptake inhibitor, were determined in squirrel monkeys trained to
respond under a fixed-interval (FI) schedule of stimulus termination and a second-order schedule of IV drug self-administration.
Intermediate doses of GBR 12909 increased FI response rate markedly, and the highest dose decreased response rate below control
values. The 5HT uptake inhibitors, alaproclate and fluoxetine, and the 5HT agonist, quipazine, attenuated the behavioral-stimulant
effects of GBR 12909, whereas the 5HT2A/2C antagonist, ritanserin, enhanced the behavioral-stimulant effects of the lowest dose. GBR 12909 reliably maintained self-administration,
and ritanserin increased response rate maintained by the highest dose. The dopamine agonist, quinpirole, increased FI response
rate in only one of three subjects, and ritanserin enhanced the behavioral-stimulant effects of quinpirole in that subject.
The dopamine agonist, apomorphine, only decreased FI response rate, and ritanserin did not alter its behavioral effects. The
pharmacological profile of GBR 12909 administered alone and in combination with selective 5HT drugs in the present study was
similar to that obtained previously with cocaine, further demonstrating that 5HT can reliably modulate the behavioral effects
of psychomotor stimulants with prominent dopaminergic actions.
Received: 9 July 1996 / Final version: 22 November 1996 相似文献
19.
School-Based Cardiovascular Health Promotion: The Child and Adolescent Trial for Cardiovascular Health (CATCH) 总被引:7,自引:0,他引:7
Cheryl L. Perry PhD Elaine J. Stone PhD MPH FASHA Guy S. Parcel PhD FASHA R. Curtis Ellison MD Philip R. Nader MD FASHA Larry S. Webber PhD Russell V. Luepker MD MS 《The Journal of school health》1990,60(8):406-413
The Child and Adolescent Trial for Cardiovascular Health (CATCH) is a multisite intervention research study that builds on significant progress made in school health education research in the 1980s. The study has three phases: Phase I deals with study design, intervention, and measurement development, Phase II involves the main trial in 96 schools in four states, and Phase III focuses on analysis. The intervention program targets third-fifth grade students and focuses on multiple cardiovascular health behaviors, including eating habits, physical activity, and cigarette smoking. Classroom curricula, school environmental change, and family involvement programs are developed for each grade level and behavioral focus. This paper describes Phase II of CATCH with a rationale for cardiovascular health promotion with youth. The process of change that appears to be necessary for school-based health promotion and that will be tested in CATCH are presented as a framework to guide these efforts. 相似文献
20.
This paper was originally developed by Calu Lester, the founder of KWICFAN, which took a novel approach to grass roots AIDS education in the black community. Calu died of AIDS before completing the work and the paper was completed by Larry L. Saxxon, who was both a friend of Calu's and an AIDS program consultant.
The paper presents a critical perspective of black America's response to the AIDS epidemic. The findings are frightening. Denial within the black community, coupled with a lack of support from the agencies responsible for funding AIDS education, has created a potential epidemiological nightmare. IV drug use continues to be a critical problem of frightening magnitude, allowing an efficient vehicle of HIV transmission. Most sadly of all, the social conditions that create and perpetuate the problematic drug abuse patterns still continue in black America. Black people are clearly becoming the new face of AIDS. 相似文献
The paper presents a critical perspective of black America's response to the AIDS epidemic. The findings are frightening. Denial within the black community, coupled with a lack of support from the agencies responsible for funding AIDS education, has created a potential epidemiological nightmare. IV drug use continues to be a critical problem of frightening magnitude, allowing an efficient vehicle of HIV transmission. Most sadly of all, the social conditions that create and perpetuate the problematic drug abuse patterns still continue in black America. Black people are clearly becoming the new face of AIDS. 相似文献