Polymethacrylate Microparticles Gel for Topical Drug Delivery

Purpose  

Evaluating the potentials of particulate delivery systems in topical drug delivery.     

补虚泻实针刺法结合卒中单元模式对肩手综合征患者肩部疼痛的影响

目的观察补虚泻实针刺法结合卒中单元模式对脑卒中后肩手综合征患者肩部疼痛的影响。方法将80例患者随机分为治疗组和对照组,每组40例。治疗组采用补虚泻实针刺法结合卒中单元模式进行治疗,对照组采用普通针刺法结合卒中单元模式进行治疗,4星期后观察两组视觉模拟评分(VAS)和总体疗效。结果治疗组总有效率为92.5%,优于对照组的87.5%(P<0.05);两组治疗后VAS均较治疗前显著减少(P<0.01),且治疗组治疗后VAS低于对照组(P<0.01)。结论补虚泻实针刺法结合卒中单元模式和普通针刺法结合卒中单元模式均能明显降低脑卒中后肩手综合征患者的肩部疼痛的程度,对脑卒中后肩手综合征有明显的治疗效果,但补虚泻实针刺法结合卒中单元模式的疗效更优一些。     

中国精神分裂症患者认知电位P300研究的系统评价

目的 评价中国精神分裂症患者认知电位P300的特点及影响因素.方法 制定原始文献的纳入标准、排除标准及检索策略,检索PubMed、EMBase、Web of knowledge、Cochrane Library、PsycINFO、中国期刊全文数据库、万方数据库、维普中文科技期刊数据库及中国生物医学文献光盘数据库等.应用加强观察性流行病学研究报告的质量(STROBE)为参照评价标准评价文献质量.采用Stata 11软件对满足纳入标准的研究资料进行Meta分析.结果 共有38篇文献符合纳入标准进行Meta分析.随机效应合并分析显示,精神分裂症患者P300波幅低于正常对照组[总效应Z=7.98,合并SMD=-0.937,95％CI( -1.167～ -0.706),P＜0.000 01],潜伏期大于正常对照组[总效应Z＝7.69,合并SMD=0.969,95％CI(0.722～1.215),P＜0.000 01],差异均有统计学意义.敏感性分析结果显示,两组的合并效应结果稳定性均较好.Meta回归显示波幅与检验仪器(P＝0.036)有关,而潜伏期可能与是否用药(P＝0.099)有关.结论 精神分裂症患者存在认知电位P300异常,表现为波幅降低和潜伏期延长,两个指标的稳定性均较好.     

Frequency of platelet-specific antigens among Koreans determined by a simplified immunofluorescence test

The frequencies of platelet-specific antigens among Oriental populations have not been well studied. This article reports the determination of the frequency of five major platelet-specific antigens among Korean blood donors. Both the PlA1 (Zwa) and Yukb antigens were positive in all of the 126 Koreans tested. Baka and Yuka antigens were positive in 110 (87.3%) and 2 (1.6%) of the 126 subjects, respectively. Ten (11.5%) of 87 Koreans had PlA2 (Zwb) antigens. A simplified immunofluorescence test, the adhesion slide immunofluorescence test, was devised for platelet antigen typing.     

FS03.7Tape stripping procedure: influence of anatomic site, application pressure, duration and removal

Background and Objectives:  Tape stripping is a common method for investigating stratum corneum (SC) physiology as well as bioavailability and bioequivalence of topical drugs. However, little is known concerning the influence of procedures (anatomic site, pressure, pressure duration, tape removal rate) inherent in each stripping protocol.
Methods:  Tape stripping was performed using tapes on the forearm, forehead and back. On the forearm different pressures (165 and 330 g cm⁻²), durations of pressure (2s and 10s), and removal rate (slow and rapid removal) was performed. Changes in skin physiology were evaluated by measurement of transepidermal water loss (TEWL) and hydration.
Results:  A significant influence of all parameters on the TEWL‐increase as a function of tape strip number was observed. The fastest increase was demonstrated on the forehead, followed by the back and, lastly, the forearm. Rapid removal produced a protracted increase in comparison to the slow removal. 10s pressure induced a faster increase of TEWL than 2s pressure. Likewise, the 330 g cm⁻² pressure induced an earlier increase than the 165 g cm⁻². Skin hydration was not influenced by the variables tested.
Conclusion:  Tape stripping results are influenced dramatically by all investigated parameters. A standardized procedure is necessary for a comparable study design. A dynamic SC stress test to more closely investigate SC cohesion is proposed based on the present observations.     

510.6nm激光对兔血管平滑肌细胞、内皮细胞选择性损伤作用的研究

目的 观察激光照射后兔血管平滑肌细胞、内皮细胞形态结构变化特点，观察激光对血管壁的损伤是否有选择性，为防止再狭窄提供实验依据。方法 用能量密度为50、100、150和200J／cm^2的铜蒸气激光照射兔腹主动脉，分别用光镜、电镜、图像分析方法，观察激光照射后第24小时，血管平滑肌细胞、内皮细胞形态、结构变化。结果 100J／cm^2能量密度的激光照射后，血管平滑肌细胞出现细胞核固缩，细胞质凝集贴边，细胞核面积均值缩小等损伤性改变。经同等剂量激光照射，而内皮细胞无明显变化。结论 经100J／cm^2的铜蒸气激光照射可损伤在体血管平滑肌细胞，而对内皮细胞无明显作用。激光对血管壁的损伤具有一定的选择性。