Rockall危险性积分在急性上消化道出血中的应用

目的：探讨Rockall危险性积分在急性上消化道出血中的应用。方法：262例按Rockall危险性积分进行评分，并分为低危组（0～3）、中危组（4～7）、高危组（≥8）。结果：高危组与中危组相比再出血率差异无统计学意义（P〉0．05）。高危组与中危组相比死亡率明显升高（P〈0．05）。结论：Rockall危险性积分对急性上消化道出血患者的病情评估具有重要的意义。     

脐带夹对防止脐部感染和出血的临床与实验研究

目的应用国产脐带夹用于农村山区破伤风高发区，并经离体试验验证其可靠性。方法经湖南、江西、广西等省基层接生员临床应用、并与当地同期或前一年未用夹者进行对照；同时经离体脐带用脐带夹、气门芯或纱线结扎阻断血管后进行金黄色葡萄球菌和破伤风毒素通透试验以及测试承受气压程度试验。结果1年临床使用2296例中，无1例发生破伤风和败血症。可靠性试验结果证明，粗纱线结扎最差，气门芯虽优于前者，但不如脐带夹。结论该脐带夹由于夹持力持久有力，细菌、毒素难以通过、安全可靠，因此能降低新生儿“病从脐入”的发病率和死亡率，有利干优生优育的贯彻．这是一项花费少、收效大的简而易行的适宜技术，值得推广。     

医德重建:传统医德危机及其解决途径探析

目前,我国面临的医德危机是非常严重的。如何解决这一危机就成了一个不容回避的重大课题,不少学者提出要用传统医德来规范医务人员,并以此作为解决该危机的良方。然而,这种以人格伦理为特质的传统医德尽管有其一定的合理性,但其在实践中的有效性却受到了人们的质疑。为此,试图从传统医德自身的局限性、医务人员利益意识的觉醒以及因社会失范而导致的越轨三个方面来分析我国医德危机产生的根源,并为此提出了三条对策。     

抗人甲状腺球蛋白单克隆抗体的制备及其对抗原决定簇特异性的研究

用杂交瘤技术建立三株分泌抗甲状腺球蛋白(TG)单克隆抗体的杂交瘤细胞株。所获三种单克隆抗体经兔抗小鼠IgG亚类、IgM及IgA血清鉴定表明,两种为IgG_1,一种为IgA;三种含单克隆抗体小鼠腹水的滴度(ELISA法)均为51200以上;以竞争性固相抗体结合试验测定它们对抗原决定簇的特异性差异,结果发现三种单克隆抗体的抗原结合部位是不同的,但对抗原的结合有一定的相互竞争抑制现象。     

RESEARCH ON A REAL-TIME CONTROL SYSTEM OF LOW POWER DISSIPATION FOR CONTINUOUS CYCLIC PERITONEAL DIALYSIS(CCPD) CYCLER

FOREWORDPeritonealdialysisrepresentssoluteandfluidexchangemainlybetweenperitonealcapillarybloodanddialysissolutionintheperitonealcavity'CombinedwithhemodialySisandrenaltransplantation,peritonealdialysisisusedmainlyforthetreatmentofrenalfailure,particularlyforchronicfailure'In1976,Prof'Popovichdevelopedcontinuousambulatoryperitonealdialysis(CAPD)basingontheconceptofcontinuousequilibrationdialysis('1'Fromthenon,peritonealdialysisfounditsclinicaluse'Continuouscyclicperitonealdialysis(CCPD…     

心血管外科术后急性肾功能衰竭的处理

目的：总结两组心血管外科术后急性肾功能衰竭病例的治疗经验，提出心血管外科术后急性肾功能衰竭的特点、早期诊断标准及处理原则。方法：１７例心血管外科术后急性肾功能衰竭病例，以入院先后分为两组。第１组８例，第２组９例。回顾第１组病例的急性肾功能衰竭的治疗经验，总结腹膜透析、血液透析和血液滤过的优缺点。在第２组病例治疗中，以急性肾功能衰竭的早期诊断为前题，早期开始腹膜透析。同时，强调综合治疗的重要性。结果：第１组病例均死亡。第２组病例，７例存活（７８％）。结论：心血管外科术后急性肾功能衰竭的早期诊断和早期肾功能替代疗法，是治疗成败的关键。腹膜透析简便易行，在急性肾功能衰竭的早期开始腹膜透析，可以收到良好效果，并以此作为心血管外科术后急性肾功能衰竭的首选肾功能替代疗法。     

不同浓度氢氟酸对大鼠血钙变化的影响

OBJECTIVE: To evaluate the effects of different concentration of hydrofluoric acid (HF) on local skin and calcium level of serum. METHODS: SD rats were divided into two groups which were wounded by 20% and 40% percent of HF respectively. Samples of blood and wound tissue were harvested at different postburn time for the analysis of the calcium level of the serum and histological study. RESULTS: It was found that twenty percent of HF was enough to cause a skin damage, and might bring about fatal hypocalcemia after a prolonged contact. High concentration of HF (40%) could cause deep tissue necrosis within a short time, and result in a fatal hypocalcemia within 24 hour even in the case of a small area injury. CONCLUSION: It is important to treat the patient with HF injury as early as possible. Sufficient calcium must be applied guided by laboratory study in order to prevent the fatal hypocalcemia.     

Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants

Calcineurin (CaN) is a Ca²⁺- and calmodulin-dependent protein phosphatase (PP2B) that, in yeast, is an integral intermediate of a salt-stress signal transduction pathway that effects NaCl tolerance through the regulation of Na⁺ influx and efflux. A truncated form of the catalytic subunit and the regulatory subunit of yeast CaN were coexpressed in transgenic tobacco plants to reconstitute a constitutively activated phosphatase in vivo. Several different transgenic lines that expressed activated CaN also exhibited substantial NaCl tolerance, and this trait was linked to the genetic inheritance of the CaN transgenes. Enhanced capacity of plants expressing CaN to survive NaCl shock was similar when evaluation was conducted on seedlings in tissue culture raft vessels or plants in hydroponic culture that were transpiring actively. Root growth was less perturbed than shoot growth by NaCl in plants expressing CaN. Also, NaCl stress survival of control shoots was enhanced substantially when grafted onto roots of plants expressing CaN, further implicating a significant function of the phosphatase in the preservation of root integrity during salt shock. Together, these results indicate that in plants, like in yeast, a Ca²⁺- and calmodulin-dependent CaN signal pathway regulates determinants of salt tolerance required for stress adaptation. Furthermore, modulation of this pathway by expression of an activated regulatory intermediate substantially enhanced salt tolerance.     

胸腺免疫抑制组分的抗变态反应作用

整体实验表明，胸腺免疫抑制组分肌内注射１ｗｋ对大鼠被动皮肤过敏反应（８、２０、５０和１２５ｍｇ·ｋｇ－１）兔Ａｒｔｈｕｓ反应（４和１２ｍｇ·ｋｇ－１）均有明显的抑制作用。体外实验表明，该药能抑制致敏豚鼠离体回肠平滑肌的过敏性收缩，ＩＣ５０为４４６．７ｍｇ·Ｌ－１。上述结果表明，胸腺免疫抑制组分有抗Ⅰ和Ⅲ型变态反应的作用。     

固体废物处理和处置设施的选址

新建废物处理和处置设施的选址是一项综合性很强的工作，涉及自然环境，社会政治和经济、安全和技术等诸多方面，选址的主要目标通过一系列的选址技术的步骤来具体体现。