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991.
992.
Objective To retrospectively analyze the therapeutic results of patients with initially di-agnosed metastatic nasopharyngeal carcinoma (NPC). Methods From January 1995 to December 1998, 46 NPC patients with distant metastases were treated in Fujian provincial cancer hospital. Among these pa-tients, 43 were single site metastasis and 3 were multiple sites metastases;The site of metastasis were 19 pa-tients in the liver, 11 in the bone, 7 in the lung, 1 in the brain, 6 in mediastinal nodes and 6 in axillary lymph nodes. All patients received standard radiotherapy to the primary site and cervical node region with a median dose of 72 Gy. Forty-one patients (89%) received 1-5 cycles chemotherapy (cisplatin and 5-flu-orouracil), and 23 (50%) received palliative irradiation to the metastatic site. Results The median surviv-al time was 20 months. The 1-, 2-, 3-year and 5-year overall survival rates were 66%, 47%, 30% and 19%, respectively. Irradiation to the metastatic sites and KPS were the significant prognostic factors. Pa-tients with palliative irradiation to the metastatic site had longer survival than those without (39 months vs. 13 months, X2=8.63, P=0.012). Patients with good performance status (KPS≥80) had better outcomes thanthose with poor performance status (26 months vs. 12 months, X2= 3.95, P=0.035) . Conclusions Active therapy may prolong the survival of patients with initially diagnosed metastatic NPC, especially for those who have good performance status. Under systematic chemotherapy, radiotherapy to the primary site and supportive care, the palliative irradiation to the metastatic site may also yield a good result. 相似文献
993.
b-catenin is a 92kDa soluble protein and arecognized component of a cell-cell adhesion regulator when coupled with cadherin[1] and is also considered to play an important role as a member in the Wingless/Wnt signal transduction pathway[2]. Combined type b-catenin combines with plasma zone of E-cad and mediatehomotypic cell-cell adhesion; free cytoplasmic typeb-catenin, Wnt protein, GSK-3b, APC and Axin etc.form Wnt signal transduction pathway. Cytoplasmic type b-catenin forms multiprotein … 相似文献
994.
CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC,RTOG consensus guidelines. 总被引:25,自引:0,他引:25
Vincent Grégoire Peter Levendag Kian K Ang Jacques Bernier Marijel Braaksma Volker Budach Cliff Chao Emmanuel Coche Jay S Cooper Guy Cosnard Avraham Eisbruch Samy El-Sayed Bahman Emami Cai Grau Marc Hamoir Nancy Lee Philippe Maingon Karin Muller Hervé Reychler 《Radiotherapy and oncology》2003,69(3):227-236
BACKGROUND AND PURPOSE: The appropriate application of 3-D CRT and IMRT for HNSCC requires a standardization of the procedures for the delineation of the target volumes. Over the past few years, two proposals--the so-called Brussels guidelines from Grégoire et al., and the so-called Rotterdam guidelines from Nowak et al.--emerged from the literature for the delineation of the neck node levels. Detailed examination of these proposals however revealed some important discrepancies. MATERIALS AND METHODS: Within this framework, the Brussels and Rotterdam groups decided to review their guidelines and derive a common set of recommendations for delineation of neck node levels. This proposal was then discussed with representatives of major cooperative groups in Europe (DAHANCA, EORTC, GORTEC) and in North America (NCIC, RTOG), which, after some additional refinements, have endorsed them. The objective of the present article is to present the consensus guidelines for the delineation of the node levels in the node-negative neck. RESULTS AND CONCLUSIONS: First a short discussion of the discrepancies between the previous Brussels and the Rotterdam guidelines is presented. The general philosophy of the consensus guidelines and the methodology used to resolve the various discrepancies are then described. The consensus proposal is then presented and representative CTVs that are consistent with these guidelines are illustrated on CT sections. Last, the limitations of the consensus guidelines are discussed and some concerns about the direct applications of these guidelines to the node-positive neck and the post-operative neck are described. 相似文献
995.
996.
目的探讨原发性小肠肿瘤(PIT)的外科诊治经验,以提高对PIT的诊治水平。方法回顾性分析1988-2003年收治的86例PIT的临床资料。结果86例中,良性肿瘤占20.9%(18虑6),恶性肿瘤占79.1%(68/86)。恶性肿瘤以腺癌多见,占41.2%(28/88)。X线检查是主要诊断手段,B超、CT、内镜、肠系膜血管造影也有助于诊断。全组均行手术治疗,其中急诊手术率为34.9%(30/86)。本组无手术死亡。恶性肿瘤1、3、5年生存率分别为73.5%、49.0%、24.5%。结论PIT术前诊断困难,误诊率与急诊手术率高。一经诊断,手术治疗是最佳选择。 相似文献
997.
998.
999.
1000.
复方甘草酸苷对SARS患者激素撤药综合征的影响 总被引:1,自引:0,他引:1
目的 :探讨复方甘草酸苷 (GL)在SARS患者减激素治疗过程中的作用。方法 :采用回顾性分析方法 ,观察GL对SARS患者的激素撤药综合征 (HWS)相关症状和指标的影响。结果 :应用GL后可使HWS症状发生率降低 ,其中SARS患者的主要症状气短、胸闷的发生率分别由24 5 %和22 6 %降低至3 6 %(P≤0 01)和7 1 %(P≤0 05) ;乏力、肌肉关节痛、头痛的发生率分别由13 2 %、15 1 %、10 4 %降至7 2 %、14 3 %、0 %;SARS患者ALT升高例数减少 (P≤0 01)。结论 :激素撤药过程中应用GL ,可以降低HWS的发生率。 相似文献