全文获取类型
收费全文 | 1567848篇 |
免费 | 113233篇 |
国内免费 | 5667篇 |
专业分类
耳鼻咽喉 | 20201篇 |
儿科学 | 50223篇 |
妇产科学 | 42975篇 |
基础医学 | 231545篇 |
口腔科学 | 44274篇 |
临床医学 | 145820篇 |
内科学 | 305011篇 |
皮肤病学 | 32142篇 |
神经病学 | 130135篇 |
特种医学 | 55039篇 |
外国民族医学 | 371篇 |
外科学 | 214325篇 |
综合类 | 33444篇 |
现状与发展 | 1篇 |
一般理论 | 522篇 |
预防医学 | 136909篇 |
眼科学 | 35057篇 |
药学 | 117317篇 |
6篇 | |
中国医学 | 4338篇 |
肿瘤学 | 87093篇 |
出版年
2021年 | 14070篇 |
2019年 | 14983篇 |
2018年 | 21911篇 |
2017年 | 15997篇 |
2016年 | 17122篇 |
2015年 | 19600篇 |
2014年 | 25855篇 |
2013年 | 39420篇 |
2012年 | 56039篇 |
2011年 | 59459篇 |
2010年 | 33696篇 |
2009年 | 30083篇 |
2008年 | 52975篇 |
2007年 | 56177篇 |
2006年 | 55787篇 |
2005年 | 53692篇 |
2004年 | 50882篇 |
2003年 | 48213篇 |
2002年 | 46486篇 |
2001年 | 69214篇 |
2000年 | 71316篇 |
1999年 | 59587篇 |
1998年 | 16704篇 |
1997年 | 14826篇 |
1996年 | 14261篇 |
1995年 | 13513篇 |
1994年 | 12546篇 |
1993年 | 11782篇 |
1992年 | 46046篇 |
1991年 | 45112篇 |
1990年 | 43618篇 |
1989年 | 41340篇 |
1988年 | 38431篇 |
1987年 | 37379篇 |
1986年 | 35664篇 |
1985年 | 34014篇 |
1984年 | 25452篇 |
1983年 | 21690篇 |
1982年 | 12876篇 |
1979年 | 23286篇 |
1978年 | 16398篇 |
1977年 | 13498篇 |
1976年 | 13232篇 |
1975年 | 13782篇 |
1974年 | 16810篇 |
1973年 | 16578篇 |
1972年 | 15383篇 |
1971年 | 14328篇 |
1970年 | 13235篇 |
1969年 | 12217篇 |
排序方式: 共有10000条查询结果,搜索用时 22 毫秒
61.
62.
63.
64.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
65.
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure 下载免费PDF全文
Daniel Coman Basavaraju G. Sanganahalli Lihong Jiang Fahmeed Hyder Kevin L. Behar 《NMR in biomedicine》2015,28(10):1257-1266
(+/?)3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) is an abused psychostimulant that produces strong monoaminergic stimulation and whole‐body hyperthermia. MDMA‐induced thermogenesis involves activation of uncoupling proteins (UCPs), primarily a type specific to skeletal muscle (UCP‐3) and absent from the brain, although other UCP types are expressed in the brain (e.g. thalamus) and might contribute to thermogenesis. Since neuroimaging of brain temperature could provide insights into MDMA action, we measured spatial distributions of systemically administered MDMA‐induced temperature changes and dynamics in rat cortex and subcortex using a novel magnetic resonance method, Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), with an exogenous temperature‐sensitive probe (thulium ion and macrocyclic chelate 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetramethyl‐1,4,7,10‐tetraacetate (DOTMA4?)). The MDMA‐induced temperature rise was greater in the cortex than in the subcortex (1.6 ± 0.4 °C versus 1.3 ± 0.4 °C) and occurred more rapidly (2.0 ± 0.2 °C/h versus 1.5 ± 0.2 °C/h). MDMA‐induced temperature changes and dynamics in the cortex and body were correlated, although the body temperature exceeded the cortex temperature before and after MDMA. Temperature, neuronal activity, and blood flow (CBF) were measured simultaneously in the cortex and subcortex (i.e. thalamus) to investigate possible differences of MDMA‐induced warming across brain regions. MDMA‐induced warming correlated with increases in neuronal activity and blood flow in the cortex, suggesting that the normal neurovascular response to increased neural activity was maintained. In contrast to the cortex, a biphasic relationship was seen in the subcortex (i.e. thalamus), with a decline in CBF as temperature and neural activity rose, transitioning to a rise in CBF for temperature above 37 °C, suggesting that MDMA affected CBF and neurovascular coupling differently in subcortical regions. Considering that MDMA effects on CBF and heat dissipation (as well as potential heat generation) may vary regionally, neuroprotection may require different cooling strategies. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
66.
Jose M. Morales Jose Angel Martinez-Flores Manuel Serrano Maria José Castro Francisco Javier Alfaro Florencio García Miguel Angel Martínez Amado Andrés Esther González Manuel Praga Estela Paz-Artal Antonio Serrano 《Journal of the American Society of Nephrology : JASN》2015,26(3):735-745
In the current immunosuppressive therapy era, vessel thrombosis is the most common cause of early graft loss after renal transplantation. The prevalence of IgA anti–β2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis is elevated (>30%), and these antibodies correlate with mortality and cardiovascular morbidity. To evaluate the effect of IgA-aB2GPI-ab in patients with transplants, we followed all patients transplanted from 2000 to 2002 in the Hospital 12 de Octubre prospectively for 10 years. Presence of IgA-aB2GPI-ab in pretransplant serum was examined retrospectively. Of 269 patients, 89 patients were positive for IgA-aB2GPI-ab (33%; group 1), and the remaining patients were negative (67%; group 2). Graft loss at 6 months post-transplant was significantly higher in group 1 (10 of 89 versus 3 of 180 patients in group 2; P=0.002). The most frequent cause of graft loss was thrombosis of the vessels, which was observed only in group 1 (8 of 10 versus 0 of 3 patients in group 2; P=0.04). Multivariate analysis showed that the presence of IgA-aB2GPI-ab was an independent risk factor for early graft loss (P=0.04) and delayed graft function (P=0.04). There were no significant differences regarding patient survival between the two groups. Graft survival was similar in both groups after 6 months. In conclusion, patients with pretransplant IgA-aB2GPI-ab have a high risk of early graft loss caused by thrombosis and a high risk of delayed graft function. Therefore, pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation. 相似文献
67.
68.
69.