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991.
B. Wrzesińska A. Czerwoniec P. Wieczorek P. Węgorek J. Zamojska A. Obrępalska‐Stęplowska 《Insect molecular biology》2014,23(5):682-693
The pollen beetle (Meligethes aeneus F.) is the most devastating pest of oilseed rape (Brassica napus) and is controlled by pyrethroid insecticides. However, resistance to pyrethroids in Europe is becoming widespread and predominant. Pyrethroids target the voltage‐sensitive sodium channel (VSSC), and mutations in VSSC may be responsible for pyrethroid insensitivity. Here, we analysed individual beetles that were resistant to esfenvalerate, a pyrethroid, from 14 populations that were collected from oilseed rape fields in Poland. We screened the VSSC domains that were presumed to directly interact with pyrethroids. We identified 18 heterozygous nucleic acid substitutions, amongst which six caused an amino acid change: N912S, G926S, I936V, R957G, F1538L and E1553G. Our analysis of the three‐dimensional structure of these domains in VSSC revealed that some of these changes may slightly influence the protein structure and hence the docking efficiency of esfenvalerate. Therefore, these mutations may impact the susceptibility of the sodium channel to the action of this insecticide. 相似文献
992.
The effects of noise in cardiac diffusion tensor imaging and the benefits of averaging complex data
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Andrew D. Scott Sonia Nielles‐Vallespin Pedro F. Ferreira Laura‐Ann McGill Dudley J. Pennell David N. Firmin 《NMR in biomedicine》2016,29(5):588-599
There is growing interest in cardiac diffusion tensor imaging (cDTI), but, unlike other diffusion MRI applications, there has been little investigation of the effects of noise on the parameters typically derived. One method of mitigating noise floor effects when there are multiple image averages, as in cDTI, is to average the complex rather than the magnitude data, but the phase contains contributions from bulk motion, which must be removed first. The effects of noise on the mean diffusivity (MD), fractional anisotropy (FA), helical angle (HA) and absolute secondary eigenvector angle (E2A) were simulated with various diffusion weightings (b values). The effect of averaging complex versus magnitude images was investigated. In vivo cDTI was performed in 10 healthy subjects with b = 500, 1000, 1500 and 2000 s/mm2. A technique for removing the motion‐induced component of the image phase present in vivo was implemented by subtracting a low‐resolution copy of the phase from the original images before averaging the complex images. MD, FA, E2A and the transmural gradient in HA were compared for un‐averaged, magnitude‐ and complex‐averaged reconstructions. Simulations demonstrated an over‐estimation of FA and MD at low b values and an under‐estimation at high b values. The transition is relatively signal‐to‐noise ratio (SNR) independent and occurs at a higher b value for FA (b = 1000–1250 s/mm2) than MD (b ≈ 250 s/mm2). E2A is under‐estimated at low and high b values with a transition at b ≈ 1000 s/mm2, whereas the bias in HA is comparatively small. The under‐estimation of FA and MD at high b values is caused by noise floor effects, which can be mitigated by averaging the complex data. Understanding the parameters of interest and the effects of noise informs the selection of the optimal b values. When complex data are available, they should be used to maximise the benefit from the acquisition of multiple averages. The combination of complex data is also a valuable step towards segmented acquisitions. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
993.
Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification
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![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
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995.
The association between smoking prevalence and eating disorders: a systematic review and meta‐analysis
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996.
Novel PSTPIP1 gene mutation in pyoderma gangrenosum,acne and suppurative hidradenitis syndrome
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997.
Analysis and comparison of statin prescription patterns and outcomes according to clinical department
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![点击此处可从《Journal of clinical pharmacy and therapeutics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
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One‐year follow‐up of titanium/zirconium alloy X commercially pure titanium narrow‐diameter implants placed in the molar region of the mandible: a randomized controlled trial
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