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81.
目的:探讨血清、尿液β2-微球蛋白(β2-mieroglobulin,β2-m)对毒性弥漫性甲状腺肿(graves diseases,Graves)患者β2-m含量与甲状腺激素的关系,了解其变化情况及临床意义。方法:采用放射免疫分析和化学发光免疫分析测定了82例Graves病初发未治疗组与同一组经治疗的69例缓解组及13例未缓解组。并和40例健康对照组进行血清、尿液β2-m含量与FT3、FL4、TGA、TMA血清检测。结果:初发组与未缓解组β2-m含量与FT3、FT4含量显著高于健康对照组(P〈0.01)。经治疗组β2-m含量与FT3、FT4含量同步缓解而下降至正常,与未治疗组对比(P〈0.01)。对比健康正常组差异无显著性(P〉0.05)。82例Graves病初发组TGA阳性率为48.7%(40/82),TMA阳性率为53.66%(44/82)。未缓解组TGA阳性率为15.38%(2/13),TMA阳性率为23.07%(3/13)。缓解组TGA、TMA仍有13.04%、15.94%阳性。结论:甲状腺疾病患者β2-m含量与甲状腺激素有密切关系,提示β2-m可作为Graves病疗效观察、病情变化及预后判断的一项辅助诊断指标。 相似文献
82.
Kyoko Sugii Hiroshi Tachimoto Akinori Syukuya Makoto Suzuki Motohiro Ebisawa 《Arerugī》2006,55(11):1400-1408
BACKGROUND/AIM: Although OAS (oral allergy syndrome) during childhood is believed to be rare, it seems to be increasing these days. METHODS, SUBJECTS: We here report 16 cases of childhood OAS, which were diagnosed, in our division. In addition to these reports, we investigated the rate of sensitization against four major pollens (Japanese cedar, orchard grass, short ragweed, alder) among 1067 pediatric patients with allergic diseases (median age: 4 years old) in our division. The sensitization was examined by IgE CAPRAST and above class 2 was judged as positive sensitization. RESULTS: OAS in childhood differs from that in adulthood in some ways. One is that childhood OAS does not always accompany with pollinosis. The most frequent allergen in our study was kiwi fruits followed by tomato, orange and melon among these patients. The sensitization rate against alder was equivalent as that against orchard grass and short ragweed, but less than that against Japanese cedar. CONCLUSION: Childhood OAS may have different mechanisms from adulthood OAS which almost always accompanies with pollinosis or latex allergy. 相似文献
83.
We have previously defined four murine CD4+ peripheral T cell subsets, fractions (Fr.) I – IV, based on expression of the 6C10 and 3G11 determinants (Hayakawa, K. and Hardy, R. R., J. Exp. Med. 1988. 168: 1825). These subsets also show distinctive levels of other cell surface markers: the two minor subsets, Fr. III and Fr. IV, are both CD45RBlow/-, L-selectin (Mel-14)? and CD44hi, characteristic of secondary T cells. The patterns and levels of cytokine production by individual cells in each subset were determined by bioassay for interleukin (IL)-2/IL-4 or IL-4/interferon (IFN)-γ production after anti-CD3 stimulation. Our data revealed that these four phenotypically defined subsets largely coincide with clusters of cells showing uniform distinctive cytokine profiles, i.e. IL-2+/IFN-γ?/IL-4? (Fr. I and Fr. II, L-selectin+), IL-2+/IFN-γ+/IL-4+ (Fr. III, L-selectin?), and IL-2?/IFN-γlow/-/IL-4+ (Fr. IV, L-selectin?). Besides these subsets, an L-selectin-negative cell subfraction within Fr. II appears to represent a transitional population between the IL-2+/IFN-γ?/IL-4? stage and the IL-2+/IFN-γ+/IL-4+ stage. Taken together, these results demonstrate the presence of two IL-4+ secondary T cell subsets with distinct cytokine production patterns, and show that the majority of IL-4+ cells found in healthy adult laboratory mice co-produce IFN-γ, and thus are not typical T helper type 2 cells. 相似文献
84.
杂种犬11只,由股动脉放血使平均动脉压(MAP)维持在6.0kPa90min后回输全部血液,继续观察150min。在休克30min后,对照组和维拉帕米处理组(Ver组)分别静脉滴注生理盐水和Ver溶液[(10μg/kg·min)15min],液体总量为3ml/kg。对照组犬在失血后心率(HR)加快,左室dp/dtmax显著降低,回输血液后MAP虽有回升,但仍低于基础值,左室dp/dtmax无明显改善;Ver使休克犬HR减慢,血液回输后MAP缓慢恢复至基础值,左室dp/dtmax显著高于对照组;电镜观察可见对照组心肌肌原纤维和线粒体等有明显的损伤,而Ver组心肌超微结构基本正常。结果还显示:Ver组犬心肌中丙二醛含量、黄嘌呤氧化酶活性低于对照组,而超氧化物歧化酶活性高于对照组。结果表明:Ver对失血性休克犬的心脏具有保护作用,其机制可能与其阻滞膜Ca2+内流、抑制脂质过氧化有关。 相似文献
85.
Qiping Yang Yue Xi Hanmei Liu Jing Luo Yufeng Ouyang Minghui Sun Cuiting Yong Caihong Xiang Qian Lin 《Nutrients》2021,13(3)
This study aims to estimate the free sugars intake, identify the primary food sources of free sugars, and explore the relationship between free sugars intake and dental caries among Chinese adolescents. This cross-sectional study included 1517 middle-school students aged 12–14 years in Changsha city, China. Adolescents completed a 12-item Food Frequency Questionnaire (FFQ) and oral health assessment. The students’ dental caries experience was available as DMFT score (number of decayed, missing, and filled permanent teeth). Statistical analyses included the Mann–Whitney test, Kruskal–Wallis test, Chi-square test, and binary logistic regression model. The average intake of free sugars was 53.1 g/d in adolescents, and 43.2% of the students consumed more than 50 g of free sugars daily. The primary contributor to free sugars was sugar-sweetened beverages (SSBs). Age, boarders, and high family income were risk factors for excessive free sugars intake (p < 0.05), and increased free sugars intake was a risk factor for dental caries (odds ratio, OR = 1.446, 95% confidence interval: 1.138–1.839). Both the free sugars intake and dental caries prevalence in Chinese adolescents were high. Targeted interventions are urgently needed to address the excessive consumption of free sugars and improve Chinese adolescents’ oral health. 相似文献
86.
异丙酚对人脐静脉内皮细胞凋亡相关基因Bcl-2及Bax表达的影响 总被引:4,自引:1,他引:3
目的 :观察异丙酚 (Propofol)及肿瘤坏死因子 α(TNF α)对培养的人脐静脉内皮细胞 (HUVECs)凋亡相关基因Bcl 2及Bax表达的影响 ,探讨异丙酚抑制凋亡的机理。方法 :将培养的人脐静脉内皮细胞 3~ 4代于融合状态 ,随机分为 7组 :对照组 (P0 ) ,2 5 μmol/L异丙酚组 (P2 5) ,TNF α组 (P0 +TNF α) ,12 .5 μmol/L异丙酚和TNF α组 (P12 .5+TNF α) ,2 5 μmol/L异丙酚和TNF α组 (P2 5+TNF α) ,5 0 μmol/L异丙酚和TNF α组 (P50 +TNF α) ,10 0 μmol/L异丙酚和TNF α组 (P10 0 +TNF α)。各组加入相应药物培养 2 4h后收获细胞 ,采用免疫细胞化学染色方法测定Bcl 2及Bax蛋白表达。结果 :与对照组 (P0 )相比 ,异丙酚 2 5 μmol/L组 (P2 5)Bcl 2及Bax蛋白表达无明显变化 (P >0 .0 5 ) ;TNF α(P0 +TNF α)组Bcl 2蛋白表达降低 ,Bax蛋白表达升高 (P <0 .0 0 1) ;而不同浓度的异丙酚预处理后再加入肿瘤坏死因子的各组 (P12 .5+TNF α、P2 5+TNF α、P50 +TNF α、P10 0 +TNF α)Bcl 2蛋白表达增加 ,Bax蛋白表达降低 (P <0 .0 5或P <0 .0 1)。结论 :临床相关浓度的异丙酚可通过调节Bcl 2及Bax蛋白表达抑制TNF α诱导的内皮细胞凋亡 相似文献
87.
Eisuke Hanada Kenji Kodama Kyoko Takano Yoshiaki Watanabe Yoshiaki Nose 《Journal of medical systems》2001,25(4):257-267
Electromagnetic interference (EMI) with electronic medical equipment by radio waves from mobile telephone handsets has been reported and is currently receiving wide attention. The possibility of EMI with electronic medical equipment by radio waves coming into the hospital has also been pointed out. But so far, there are no reports measuring the frequency distribution of electric field intensity induced by incoming radio waves. Therefore, we measured electric field intensity induced by radio waves coming into our 11-floor hospital, which was under construction. The maximum intensity observed was about 200 V/m at 2.79 GHz, from airport surveillance radar waves. The maximum intensity induced by radio waves from cellular phone base stations was 1.78 V/m. These data show that various frequencies of radio waves are common in this urban area, and that they induce strong electric field intensity. This strong electric field intensity might cause EMI with electronic medical equipment. Measurement of the electromagnetic environment should be done by each hospital in urban areas to prevent EMI with electronic medical equipment. 相似文献
88.
The aim of this study was to assess the relationship between serum folic acid (FA) levels and erectile dysfunction (ED) through a meta-analysis. A research was conducted in MEDLINE via PubMed, Cochrane Library, EMBASE and Web of Science up to 22 November 2020 to identify studies related to FA and ED. Two authors independently screened the literature, evaluated methodological quality and extracted the data. We used RevMan5.3 and STATA 14.0 for meta-analysis. A total of six studies including 1,842 participants were included, and the results showed that the FA levels in the non-ED group were significantly higher than those in the ED group (MD = 3.37, 95% CI 1.49–5.52, p = 0.004). Subgroup analysis indicated that with the increase in ED severity, the difference in FA levels between groups was more obvious (MD: 1.99 vs. 4.63 vs. 5.63). The differences in FA levels between groups seem more significant in the younger group (MD = 4.87, 95% CI 2.58–6.89, p < 0.001) than in the older group (MD = 3.15, 95% CI 2.21–4.08, p < 0.001). In conclusion, FA deficiency is closely related to ED, and the degree of FA deficiency may reflect the severity of ED. In addition, the association seems to be more pronounced in the younger group. 相似文献
89.
Long Gongwei Zhang Yucong Sun Guoliang Ouyang Wei Liu Zheng Li Heng 《Lasers in medical science》2021,36(9):1807-1816
Lasers in Medical Science - The thulium laser resection of bladder tumor (TmLRBT) is widely used in the treatment of non-muscle-invasive bladder cancer (NMIBC), and we conduct this study to compare... 相似文献
90.
目的研究微小RNA(microRNA,miR)-362在不同级别星形细胞瘤中的表达,探讨其临床意义及价值。方法使用定量聚合酶链反应(PCR)方法比较长治医学院附属和平医院32例星形细胞瘤患者和4例正常脑组织中miR-362的表达。多组间比较采用单因素方差分析,两组间比较使用配对t检验。结果所有星形细胞瘤组织miR-362表达(0.194±0.052)明显低于正常脑组织miR-362表达(0.436±0.044,t=8.887,P<0.05),差异有统计学意义,其中低级别星形细胞瘤组织miR-362表达(0.172±0.045)和高级别星形细胞瘤(0.202±0.070)均明显低于正常脑组织miR-362表达(t=10.101,t=6.386,P<0.05),差异有统计学意义,但低级别星形细胞瘤组织miR-362表达与高级别星形细胞瘤miR-362表达之间差异无统计学意义(t=1.284,P>0.05)。结论miR-362在星形细胞瘤组织中表达下调,但在低级别与高级别星形细胞瘤间无差异。 相似文献