海绵状血管瘤内压监测指导栓塞及硬化剂注射治疗

为探讨在栓塞硬化海绵状血管瘤中瘤腔内变化规律及其意义，在２９例治疗过程中给机械性减缓交界本静脉回流，进行了瘤腔内压连续监测，发现：瘤腔基础内压力０．６６７～２．０ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）。颈部最低，回流快者所需栓塞次数多，用量大，瘤腔内压力曲线在栓塞初始为平台波形，提示回流静脉逐一被栓塞，随后出现缓慢下降的印峰波形，去除瘤体表浅回流静脉机械性压迫，瘤腔内压不变，提示回流静脉全部栓塞，可注     

Immunization strategies for the production of rat monoclonal anti-idiotope antibodies

Anti-idiotypic antibodies are powerful reagents for the study of immunoregulation, and have potential interest as vaccines against tumors and infectious diseases. Three immunization strategies for the production of rat monoclonal anti-idiotope antibodies have been compared in this paper. Male Wistar rats were immunized i.p. and at multiple subcutaneous sites with 750 micrograms of purified monoclonal antibody against Plasmodium falciparum for three times and subsequently boosted by (1) intraperitoneal injection with 750 micrograms of the immunogen, (2) intravenous inoculation with 400 micrograms of the IgG, and (3) intrasplenic immunization with 200 micrograms of the idiotype. With the intraperitoneal boost method, the frequency of hybrids with anti-idiotope activity was 0.3-0.9% with 62.8-85.2% of the seeded wells containing hybrids. In the intravenous boost group, the percentage of hybrids demonstrating anti-idiotope activity increased to 11.0-13.3% with 80.2-97.9% of the hybrid efficiency. When immunized by the intrasplenic boost route, the frequency of anti-idiotope hybrids generated rose to 12.9-16.4% with 82.3-96.6% of the hybrid efficiency. There was no obvious effect of the boost immunizing methods on the generation of rat monoclonal anti-mouse IgG antibodies. These results indicated that the multiple-site immunization followed by intravenous or intrasplenic boost injection was an appropriate immunizing method for the production of monoclonal anti-idiotope antibodies.     

含碘食物对Graves病患者甲状腺^131I与^99mTc摄取的不同影响

目的 探讨含碘食物对Graves病患者摄取^99mTc与^131I的影响。方法 选择曾食含碘食物的Graves病患者20例，在禁食含碘食物前后分两次进行摄^131I试验与甲状腺^99mTc显像．前者测定3、24h摄^131I率，后者计算摄锝指数(TI)及估算甲状腺质量(TW)。采用Wilcoxon符号秩和检验对数据进行对比分析。结果 20例患者禁止含碘食物前后的摄^131I率显著不同，所有患者禁食含碘食物后3和24h摄^131I率均显著增高。TI2例未变、2例增高、16例降低；TM18例减小、2例增大。较未禁食含碘食物的首次检测，两者均有显著性变化。结论 含碘食物对甲状腺摄取Na^99mTcO4的影响与Na^131I显著不同，含碘食物100％减低甲状腺^131I的摄取而90％锝摄取增高。     

THE EFFECT OF ACUPUNCTURE ON PREVENTION AND TREATMENT OF ISCHEMIC ARRHYTHMIA AND THE RELATION BETWEEN EFFECT OF ACUPUNCTURE AND CHOLINERGIC MUSCARINE-LIKE RECEPTORS

For investigating the effect of acupuncture on ischemic arrhythmia and its mech-anism, adult albino rats with ligated anterior descending branch of coronary artery as experimentalmodel were treated with or without acupuncture, and others with imitative operation but without bothcoronary artery ligation and acupuncture treatment were used as control. It was found in acupuncturegroup that the fibrillation-liability of ischemic myocardium was efficiently decreased, the affinity ofAch-M receptors on membranes of ischemic myocardium was markedly increased, and the tolerance ofischemic myocardium to atropine was elevated in the experiment of atropine inducing fibrillation.These results indicate that acupuncture may play a therapeutic role on ischemic arrhythmia throughactivating the activity of muscarine-like receptors of cholinergic nervous system.     

小剂量异丙酚加喉上神经阻滞用于纤支镜检查

目的：观察异丙酚加喉上神经阻滞用于纤支镜检查期间，患对操作刺激反应、耐受程度以及对心血管反应和遗忘程度。方法：选40例拟诊肺癌患行ASAⅡ～Ⅲ纤支镜检查，喉上神经阻滞成功后推注0．5～1mg／kg异丙酚，患意识消失后，进行纤支镜操作。结果：所有病人都能耐受检查。术中收缩压、舒张压、心率、血氧饱和度等无明显影响，无恶心、呕吐等并发症，大大减轻了检查对病人带来的痛苦。结论：异丙酚加喉上神经阻滞用于纤支镜检查，对呼吸、循环影响小，能减轻病人痛苦，术后具有遗忘作用，值得推广。     

A new Le Fort I internal distraction device in the treatment of severe maxillary hypoplasia.

PURPOSE: The purpose of this pilot study was to test a new Le Fort I internal distraction device. PATIENTS AND METHODS: A new internal Le Fort I distraction device designed by 1 of the authors was used in 3 patients with cleft lip and palate and severe maxillary hypoplasia who needed maxillary advancements in excess of 12 mm. Presurgical planning used CASSOS (SoftEnable Technology, Ltd, Hong Kong SAR, China) prediction tracing software and a stereolithographic model to calculate the distraction vector. The distractors were pre-bent and installed on the stereolithographic model and activated to advance the maxilla. Surgery was performed in a conventional manner, and distraction was started after a 7-day latency phase at the rate of 1 mm/day and continued until the presurgical plan was achieved. The distractor was removed after a 3-month consolidation phase. Cephalometric radiographs were taken at the completion of each phase. RESULTS: This new Le Fort I internal distraction device successfully distracted the maxillae as planned in all 3 patients. At the end of the distraction phase, the maxillary advancement was measured at 15.8 mm, 15.8 mm, and 13.5 mm, respectively. In each patient, a clockwise rotation of the maxilla was observed with a tendency to a posterior open bite. Postoperative radiographs also showed that the actual distraction vectors differed from the planned vectors. After the consolidation phase, radiographs showed a relapse of 2.6 mm, 0 mm, and 5.0 mm, respectively. There was no further relapse on 3-month follow-up radiographs. Each case showed radiographic evidence of excellent new bone formation at the osteotomy sites. CONCLUSION: The new Le Fort I internal distraction device produced the necessary advancement in all 3 patients. The study also showed that the actual distraction vector differed from the planned vector. This discrepancy was caused by a clockwise rotation of the maxilla during the distraction. Finally, the study showed a variable relapse rate not previously reported in maxillary distraction.     

高血压病心尖搏动图的改变

50例高血压病人ACG和 FDACG 检测的结果显示:高血压病不论舒张压高低或有无心脏增大,均有舒张功能改变,表现为A/EO 比值增高,A_2-dA/dt-min 和A_2O延长。此三项指标的异常出现率分别为40％、30％及14％,三项联合检测其中任何一项异常的出现率为54％。收缩功能无明显改变。治疗显效后,A/EO降低,A_2-dA/dt-min 缩短,说明心功能明显改善。     

有助于残根修复的牙冠延长术

牙折裂达龈下、或龋坏导致的残根达龈下时,修复常难以进行,残根往往被拔除。然而,若对残根进行完善的根管治疗,再采用一定的方法使牙断缘暴露出来,则残根可以被保留并可进行修复。在暴露残根断缘的方法中,有学者采用牵引方法,将儿童和青少年外伤牙的残根牙缘牵至龈上,但这需要较长的时间和过程,有时还会有回缩的现象[1] 。大多数医生以往多采用牙龈切除术来暴露牙断缘,但随之而来的问题是,在尚未来得及修复时牙龈又恢复至原来水平。因而有的医生在术后第2天就进行修复,有的则用电刀切除牙龈之后立即修复,然而,在修复之后,牙龈往往会有长时间…     

The Effect of Acupuncture on Bone Mineral Density in Postmenopausal Women

According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by the method of reinforcing the kidney to strengthen the bone, with satisfactory therapeutic results reported as follows.     

Agilent 2100 Bioanalyzer在基因差异表达研究中的应用

目的：观察Agilent2100 Bioanalyzer芯片分析系统（以下简称Bioanalyzer）在基因差异表达研究中的应用。方法：应用限制性显示技术分别从正常和热休克处理后的酿酒酵母细胞中分离出cDNA片段，然后再用Bioanalyzer和传统的琼脂糖凝胶电泳技术对RD-PCR产物进行检测分析。结果：Bioanalyzer能更快速、敏感地分离和显示差异表达的基因片段，并且通过对差异片段进行定量比较，发现了数个表达有明显差异的基因片段。结论：Bioanalyzer在基因差异表达研究中具有重要的应用价值。