全文获取类型
收费全文 | 11707篇 |
免费 | 725篇 |
国内免费 | 132篇 |
专业分类
耳鼻咽喉 | 195篇 |
儿科学 | 95篇 |
妇产科学 | 146篇 |
基础医学 | 2091篇 |
口腔科学 | 329篇 |
临床医学 | 966篇 |
内科学 | 1896篇 |
皮肤病学 | 460篇 |
神经病学 | 1053篇 |
特种医学 | 715篇 |
外科学 | 1643篇 |
综合类 | 77篇 |
一般理论 | 2篇 |
预防医学 | 468篇 |
眼科学 | 283篇 |
药学 | 1252篇 |
中国医学 | 151篇 |
肿瘤学 | 742篇 |
出版年
2024年 | 3篇 |
2023年 | 52篇 |
2022年 | 227篇 |
2021年 | 478篇 |
2020年 | 203篇 |
2019年 | 306篇 |
2018年 | 368篇 |
2017年 | 281篇 |
2016年 | 392篇 |
2015年 | 508篇 |
2014年 | 657篇 |
2013年 | 749篇 |
2012年 | 1049篇 |
2011年 | 989篇 |
2010年 | 646篇 |
2009年 | 550篇 |
2008年 | 747篇 |
2007年 | 742篇 |
2006年 | 670篇 |
2005年 | 570篇 |
2004年 | 484篇 |
2003年 | 400篇 |
2002年 | 324篇 |
2001年 | 223篇 |
2000年 | 192篇 |
1999年 | 132篇 |
1998年 | 83篇 |
1997年 | 65篇 |
1996年 | 51篇 |
1995年 | 55篇 |
1994年 | 36篇 |
1993年 | 24篇 |
1992年 | 38篇 |
1991年 | 34篇 |
1990年 | 35篇 |
1989年 | 35篇 |
1988年 | 26篇 |
1987年 | 23篇 |
1986年 | 17篇 |
1985年 | 10篇 |
1984年 | 15篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1979年 | 7篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1968年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
961.
Fc receptor-dependent myelin phagocytosis has been proposed as a mechanism of demyelination in multiple sclerosis (MS). The object of this study was to determine whether MS patients' sera are more opsonic for myelin than normal controls' sera. Opsonization was tested by culturing thioglycollate elicited murine peritoneal macrophages with 125I-labelled, serum-sensitized bovine central myelin. The two groups of sera were found to opsonize myelin equally well after 30 and 120 min incubations. We conclude that MS patients' sera are not more opsonic for myelin than sera from normal controls. 相似文献
962.
Ilir Agalliu Erika M. Kwon Claudia A. Salinas Joseph S. Koopmeiners Elaine A. Ostrander Janet L. Stanford 《Cancer causes & control : CCC》2010,21(2):289-300
Objective
DNA repair pathways are crucial to prevent accumulation of DNA damage and maintain genomic stability. Alterations of this pathway have been reported in many cancers. An increase in oxidative DNA damage or decrease in DNA repair capacity with aging or due to germline genetic variation may affect prostate cancer risk. 相似文献963.
964.
965.
Won Cheol Yim Changwon Keum Saehwan Kim Yeojeong Cho Byung-Moo Lee Yongeun Kwon 《Toxicology and Environmental Health Sciences》2010,2(1):25-38
17β-estradiol (E2) is an environmental estrogen-like chemicals that is known to affect mainly reproductive functions of exposed targets. Although microarray based toxicogenomics approach allows the investigation of the potential risks of E2 in DNA level, the underling mechanisms related to their toxic effect is not fully understood. In this work, we identified genes responding toE2 by analyzing cross-experiment public gene expression datasets that studied on E2 using RankProd algorithm. We have identified 348 DEGs which play important roles in fatty acid metabolism, infection, and DNA repair. This result was also compared with conventional PubMed data mining analysis. 相似文献
966.
967.
Ji Min Park Ha Yoon Bong Hye In Jeong Yeon Kyoung Kim Ji Yeon Kim Oran Kwon 《Nutrition Research And Practice》2009,3(4):272-278
Postprandial hypoglycemic effect of mulberry leaf (Morus alba L.) was compared in two animal models: Goto-Kakizaki (GK) rats, a spontaneous non-obese animal model for type II diabetes, and their counterpart control Wistar rats. First, the effect of a single oral administration of mulberry leaf aqueous extract (MLE) on postprandial glucose responses was determined using maltose or glucose as substrate. With maltose-loading, MLE reduced peak responses of blood glucose significantly in both GK and Wistar rats (P < 0.05), supporting the inhibition of α-glucosidase by MLE in the small intestine. With glucose-loading, MLE also significantly reduced blood glucose concentrations, measured at 30 min, in both animal models (P < 0.01), proposing the inhibition of glucose transport by MLE. Next, dried mulberry leaf powder (MLP) was administered for 8 weeks by inclusion in the diet. By MLP administration, fasting blood glucose was significantly reduced at weeks 4 and 5 (P < 0.05), but then returned to values that were similar to those of the control at the end of experimental period in GK rats. Insulin, HOMA-IR, C-reactive protein, and triglycerides tended to be decreased by MLP treatment in GK rats. All other biochemical parameters were not changed by MLP administration in GK rats. Collectively, these findings support that MLE has significant postprandial hypoglycemic effect in both non-obese diabetic and healthy animals, which may be beneficial as food supplement to manage postprandial blood glucose. Inhibitions of glucose transport as well as α-glucosidase in the small intestine were suggested as possible mechanisms related with the postprandial hypoglycemic effect of MLE. 相似文献
968.
Myung-Hee Kwon Myung-Shin Lee Kyongmin Hwang Kim Sun Park Ho-Joon Shin Young-Ju Jang Hyung-Il Kim 《Immunological investigations》2002,31(3):205-218
A well-characterized recombinant anti-idiotype to an anti-DNA antibody can be useful for studies of the regulation of anti-DNA-producing B cells. Using a hybridoma technique, a monoclonal anti-idiotypic antibody, designated O2F3, was obtained, and its scFv gene was constructed. O2F3 single chain Fv (scFv) was produced against an idiotope of a monoclonal anti-DNA antibody, 3D8, that was obtained from an autoimmune-prone mouse, MRL-lpr/lpr. Here we describe the production and in vitro characterization of the O2F3 scFv, and compare it with its parent monoclonal antibody, O2F3 IgM. To characterize O2F3 scFv and O2F3 IgM, we generated recombinant 3D8 fragments, including 3D8 scFv, 3D8 VH, and 3D8 VL, that were used as antigens in several assays. ELISA and Western blot analysis showed that both O2F3 scFv and O2F3 IgM recognized a conformational determinant formed by the association of the variable region heavy and light chains of the 3D8 antibody, suggesting that O2F3 scFv retained a similar binding pattern to its parent O2F3 antibody. The idiotope recognized by O2F3 was shown by competitive ELISA to be outside of the DNA binding site of the 3D8 antibody. This characterized O2F3 scFv could be applied for the regulation of anti-DNA antibody production and the manipulation of recombinant antibody-based proteins to which toxins, enzymes, and chemical agents can be connected. 相似文献
969.
970.