全文获取类型
收费全文 | 898篇 |
免费 | 50篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 39篇 |
妇产科学 | 5篇 |
基础医学 | 121篇 |
口腔科学 | 44篇 |
临床医学 | 74篇 |
内科学 | 183篇 |
皮肤病学 | 40篇 |
神经病学 | 38篇 |
特种医学 | 149篇 |
外国民族医学 | 1篇 |
外科学 | 69篇 |
综合类 | 42篇 |
预防医学 | 58篇 |
眼科学 | 7篇 |
药学 | 53篇 |
中国医学 | 1篇 |
肿瘤学 | 28篇 |
出版年
2021年 | 4篇 |
2020年 | 6篇 |
2019年 | 9篇 |
2018年 | 11篇 |
2017年 | 14篇 |
2016年 | 13篇 |
2015年 | 25篇 |
2014年 | 14篇 |
2013年 | 30篇 |
2012年 | 28篇 |
2011年 | 25篇 |
2010年 | 30篇 |
2009年 | 47篇 |
2008年 | 31篇 |
2007年 | 26篇 |
2006年 | 18篇 |
2005年 | 22篇 |
2004年 | 32篇 |
2003年 | 26篇 |
2002年 | 12篇 |
2001年 | 6篇 |
2000年 | 7篇 |
1999年 | 19篇 |
1998年 | 54篇 |
1997年 | 62篇 |
1996年 | 56篇 |
1995年 | 42篇 |
1994年 | 40篇 |
1993年 | 38篇 |
1992年 | 7篇 |
1991年 | 11篇 |
1990年 | 16篇 |
1989年 | 14篇 |
1988年 | 22篇 |
1987年 | 23篇 |
1986年 | 21篇 |
1985年 | 9篇 |
1984年 | 4篇 |
1983年 | 8篇 |
1982年 | 18篇 |
1981年 | 3篇 |
1980年 | 9篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1975年 | 3篇 |
1968年 | 3篇 |
1966年 | 3篇 |
1959年 | 2篇 |
排序方式: 共有957条查询结果,搜索用时 15 毫秒
91.
Manna R; Todaro L; Latteri M; Gambassi G; Massi G; Grillo MR; Romito A; Caputo S; Gasbarrini GB 《Rheumatology (Oxford, England)》1997,36(1):124-125
The actiopathogenesis of leucocytoclastic vasculitis is still unknown, but
recently hepatitis C virus (HCV) has been suggested as trigger of
autoimmunity. We report a case of a 26-yr-old patient with purpura due to
leucocytoclastic vasculitis associated with hepatitis C virus infection.
Laboratory findings showed AST, ALT, gamma GT within normal limits,
positive antibodies to HCV (IIF and Riba II) and polymerase chain reaction
for HCV RNA. Anti-nuclear antibodies, IgG and IgM anti- cardiolipin
antibodies, anti-platelet antibodies and anti-neutrophil cytoplasmic
antibodies with perinuclear pattern were also present. A skin biopsy
specimen of a purpuric lesion showed leucocytoclastic vasculitis with small
vessel thrombosis and perivascular deposition of IgM and fibrinogen on
immunofluorescence study. This case shows a role of HCV in leucocytoclastic
vasculitis; it is possible that this HCV can induce autoimmunity
independently of cryoglobulins and liver involvement.
相似文献
92.
Differentiation of thrombi from slow flow in the pulmonary arteries, sometimes observed in the presence of pulmonary arterial hypertension, can be equivocal. Magnetic resonance (MR) imaging was performed in a patient with chronic pulmonary thromboembolism and pulmonary arterial hypertension using an electrocardiographically gated technique that allowed visualization of the pulmonary arteries at the end of diastole and multiple times during systole. These images were compared with those of a patient with primary pulmonary hypertension and those of healthy subjects. Thrombi were discrete structures, seen throughout the cardiac cycle on both the first and second spin-echo images, and decreased in signal intensity on the second image. Slow flow increased in signal intensity and changed in structure during the cardiac cycle and was seen best on the second image. MR may play an important role in excluding large central thrombi as the cause of pulmonary arterial hypertension. It is a noninvasive method for defining pulmonary arterial wall thickness and for direct visualization of chronic pulmonary thrombus. 相似文献
93.
G Micali † MR Nasca † R De Pasquale † D Innocenzi‡ 《Journal of the European Academy of Dermatology and Venereology》2003,17(3):320-323
Kaposi's sarcoma is a vascular tumour of multifocal origin occurring primarily on the extremities. The case of a 45-year-old HIV negative and HHV-8 positive man with an asymptomatic reddish macular lesion on the inner layer of the prepuce is described. Although primary penile Kaposi's sarcoma is a relatively uncommon disorder in HIV negative men, dermatologists and venereologists should consider this possibility when treating non-specific penile lesions. A minimal penile lesion with non-distinctive clinical features may sometimes be the exclusive manifestation of Kaposi's sarcoma, making histologic evaluation necessary to establish the diagnosis. 相似文献
94.
MR Carvalho ; MA Krieger ; E Almeida ; W Oelemann ; MA Shikanai-Yassuda ; AW Ferreira ; JB Pereira ; A Saez-Alquezar ; PE Dorlhiac-Llacer ; DF Chamone ; et al. 《Transfusion》1993,33(10):830-834
Blood transfusion is one of the principal routes of transmission of Chagas' disease, a major endemic disease in Latin America. Methods for blood screening are not accurate and may yield false results that lead to high social and economic costs. This study compares two methods of diagnosing Chagas' disease (indirect immunofluorescence and hemagglutination) and several enzyme-linked immunosorbent assays (ELISAs) with regard to specificity and sensitivity, by using human sera with known serologic and parasitologic characteristics, as well as samples with discrepant results on conventional serologic tests. An ELISA using recombinant antigens showed no cross-reactivity with sera that were positive for other diseases. All evaluated ELISAs performed well, and their use may lead to a reduction of more than 50 percent in the number of discordant sera. Further improvements are needed in view of the complexity of the serologic diagnosis of Chagas' disease. 相似文献
95.
一体化PET/MR检查护理规范是关于PET/MR检查过程中对于护理人员的工作要求,包括检查前准备、注射药物护理、检查时护理、检查后护理、对比剂不良反应处理和个人辐射防护。旨在为核医学科护士在临床PET/MR检查中提供实用且行之有效的处理操作规范。 相似文献
96.
Bishop MR; Anderson JR; Jackson JD; Bierman PJ; Reed EC; Vose JM; Armitage JO; Warkentin PI; Kessinger A 《Blood》1994,83(2):610-616
Between June 1989 and June 1992, 144 patients participated in sequential clinical trials using peripheral blood progenitor cells (PBC) as their sole source of hematopoietic rescue following high-dose chemotherapy. All patients had received prior extensive combination chemotherapy and had marrow defects that precluded autologous bone marrow transplantation (ABMT). PBC were collected according to a single apheresis protocol. The initial 86 patients (group 1) had PBC collected without mobilization. Beginning in April 1991, PBC were mobilized solely with recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF). Thirty-four patients (group 2) received rHuGM-CSF at a dose of 125 micrograms/m2/d by continuous intravenous infusion, and 24 patients (group 3) received rHuGM-CSF at a dose of 250 micrograms/m2/d by continuous intravenous infusion. Patients underwent at least six aphereses and had a minimum of 6.5 x 10(8) mononuclear cells (MNC)/kg collected. Cytokines were not routinely administered immediately after transplantation. A median of nine aphereses were required to collect PBC in group 1 and seven aphereses for groups 2 and 3 (P = .03). The time required to recover 0.5 x 10(9)/L granulocytes after transplant was significantly shorter (P = .0004) for the mobilized groups; the median time to recovery was 26 days for group 1, 23 days for group 2, and 18 days for group 3. Transplantation of PBC mobilized with rHuGM-CSF resulted in a shorter time to platelet (P = .04) and red blood cell (P = .01) transfusion independence. Mobilization with rHuGM-CSF alone resulted in efficient collection of PBC, that provided rapid and sustained restoration of hematopoietic function following high-dose chemotherapy. Mobilization of PBC with rHuGM-CSF alone is an effective method for patients who have received prior chemotherapy and have bone marrow abnormalities. 相似文献
97.
M Alidoosti M Salarifar SE Kassaian AMH Zeinali MS Fathollahi MR Dehkordi 《Cardiovascular journal of Africa》2008,19(6):297-302
Background
Direct stenting without balloon dilatation may reduce procedural costs and duration, and hypothetically, the restenosis rate. This study was designed to compare the in-hospital and long-term outcomes of direct stenting (DS) versus stenting after pre-dilatation (PS) in our routine clinical practice.Methods
The 1 603 patients treated with stenting for single coronary lesions were enrolled into a prospective registry. Patients with acute myocardial infarction (MI) within the preceding 48 hours, and those with highly calcified lesions, total occlusions, or a lesion in a saphenous graft were excluded. The baseline, angiographic and procedural data, inhospital outcomes and follow-up data were recorded in our database and analysed with appropriate statistical methods.Results
Eight hundred and fifty-seven patients (53.5%) were treated with DS and 746 (46.5%) underwent PS. In the DS group, lesions were shorter in length, larger in diameter and had lower pre-procedural diameter stenosis. Type C and diffuse lesions and drug-eluting stents were found less often (p < 0.001). With univariate analysis, dissection and non-Q-wave MI occurred less frequently in this group (0.2 and 0.6% vs 3.9 and 2.1%, p < 0.001 and p = 0.01, respectively). However, the cumulative major adverse cardiac events (MACE) did not differ significantly (4.9 vs 4.6%, p = 0.79). With multivariate analysis, direct stenting reduced the risk of dissection (OR = 0.07, 95% CI: 0.01–0.33, but neither the cumulative endpoint of MACE (OR = 1.1, 95% CI = 0.58–2.11, p = 0.7) nor its constructing components were different between the groups.Conclusions
Direct stenting in the real world has at least similar long-term outcomes in patients treated with stenting after pre-dilatation, and is associated with lower dissection rates. 相似文献98.
99.
100.
Papic N Pangercic A Vargovic M Barsic B Vince A Kuzman I 《Influenza and other respiratory viruses》2012,6(3):e2-e5
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury. 相似文献