Systemic thrombolytic therapy of myocardial infarction

Systemic thrombolytic therapy was given to 67 patients with large-focal myocardial infarction: immobilized streptokinase (streptodecase) was administered to 37 patients, and native thrombolytic drugs (streptokinase or urokinase), to 30 patients. Systemic thrombolytic therapy initiated within 6 hours of the attack was shown to affect favorably the course of myocardial infarction, as manifested in a significant reduction of the incidence of protracted disease and arrhythmias, and rapid elimination of congestive heart failure. The two regimens being equally effective in clinical terms, immobilized streptokinase was associated with considerably reduced rates of specific side-effects common to thrombolytic therapy.     

Histocompatibility antigens and the solitary keratoacanthoma

Standard microlymphocytic cytotoxic test was used in 43 cases of solitary keratoacanthoma. Increased incidence of HLA-B16 and HLA-B18 antigens was established. Presence of HLA-A2 was shown to adversely influence the course of the disease.     

Action of apilak on the electrolyte and catecholamine content of the wall of arterial vessels at different levels of systemic arterial pressure

In cats with elevated systemic arterial blood pressure apilac (1 mg/kg, a single dose or course administration) significantly decreased the arterial vessel wall contents of ions of Na+, Ca2+ and catecholamines the levels of which exceeded control values. Apilac administration to animals with normal systemic arterial blood pressure resulted in a decrease of Ca2+ ion content, an increase of Na+, K+ and Mg2+ ion concentrations in the vessel wall. The content of catecholamines remained in the range of control values.     

The epidemiological assessment of the "dose-response" relationship in the hygienic regulation of asbestos-containing dusts]

"Dose-response" dependence worked out by American scientists helped to reveal the linear dependence between carcinogenic risk factor, asbestos containing dust, and lung cancer formation, use it for basing the new MAC for asbestos containing dust taking into account the oncologic security.