全文获取类型
收费全文 | 328篇 |
免费 | 29篇 |
国内免费 | 29篇 |
专业分类
儿科学 | 14篇 |
妇产科学 | 2篇 |
基础医学 | 19篇 |
口腔科学 | 25篇 |
临床医学 | 46篇 |
内科学 | 68篇 |
皮肤病学 | 8篇 |
神经病学 | 18篇 |
特种医学 | 112篇 |
外科学 | 9篇 |
综合类 | 22篇 |
预防医学 | 7篇 |
药学 | 26篇 |
肿瘤学 | 10篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 1篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 2篇 |
2011年 | 5篇 |
2010年 | 6篇 |
2009年 | 12篇 |
2008年 | 6篇 |
2007年 | 15篇 |
2006年 | 6篇 |
2005年 | 16篇 |
2004年 | 3篇 |
2003年 | 6篇 |
2002年 | 9篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 21篇 |
1997年 | 25篇 |
1996年 | 21篇 |
1995年 | 9篇 |
1994年 | 24篇 |
1993年 | 23篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 19篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 4篇 |
1985年 | 12篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 13篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1971年 | 1篇 |
排序方式: 共有386条查询结果,搜索用时 15 毫秒
61.
62.
63.
GD单抗治疗神经母细胞瘤临床应用协作组 《临床儿科杂志》2022,40(1):14-20
神经母细胞瘤(neuroblastoma,NB)是儿童最常见的颅外实体肿瘤,临床表现及预后具有高度异质性。低危患儿预后较好,高危患儿即使接受化疗、放疗、手术、造血干细胞移植等多种方法的综合治疗,长期存活率仍不足50%。探索潜在的治疗靶点对于提高高危患者的生存率具有重要意义。双唾液酸神经节苷脂抗原GD2在NB细胞高表达,达妥昔单抗β可与NB细胞膜表面过表达的GD2特定靶点结合,触发抗体依赖性细胞介导的细胞毒性作用和补体依赖的细胞毒性效应,通过双重免疫机制而发挥抗肿瘤作用。通过总结国外多项关键临床研究,并结合在海南和天津医疗先行区的上市前初步应用经验,我们对达妥昔单抗β的安全性、有效性、适用人群及使用方法进行总结和推荐,提出本共识,旨在为临床医师提供指导与帮助。 相似文献
64.
65.
66.
Enzmann DR; Wheat R; Marshall WH; Bird R; Murphy-Irwin K; Karbon K; Hanbery J; Silverberg GD; Britt RH; Shuer L 《Radiology》1985,154(2):393-399
Intraoperative ultrasound (US) was compared to computed tomography (CT) in 41 intracranial and 6 spinal cord tumors. The studies correlated closely except for primary gliomas. Eight of the 22 primary intracranial gliomas (37%), including 1 low-grade and 7 anaplastic tumors, were larger and more extensive on US than on CT. Margins of non-enhanced primary astrocytomas were shown by US but not CT. Four anaplastic tumors (19%) exhibited echogenicity extending beyond the enhanced area. In 4 patients an enhanced lesion contained a lucent center which proved to be echogenic. Low-grade astrocytomas were relatively homogeneous on US, while anaplastic astrocytomas were more inhomogeneous. Cysts could be found in both types of astrocytomas and were often small and multiple. The echo pattern was not helpful in differentiating metastases from primary tumors, although all of them had sharp margins. Sonography of the central nervous system can provide valuable information about tumor morphology and margins. 相似文献
67.
Cerebral microgyria, thalamic cell size and auditory temporal processing in male and female rats 总被引:4,自引:2,他引:2
Herman AE; Galaburda AM; Fitch RH; Carter AR; Rosen GD 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(5):453-464
Induction of microgyria by freezing injury to the developing somatosensory
cortex of neonatal rats causes a defect in fast auditory processing in
males, but not in females. It was speculated that early damage to the
cortex has sexually dimorphic cascading effects on other brain regions
mediating auditory processing, which can lead to the observed behavioral
deficits. In the current series of experiments, bilateral microgyri were
induced by placement of a freezing probe on the skulls of newborn male and
female rats, and these animals were tested in adulthood for auditory
temporal processing. Control animals received sham surgery. The brains from
these animals were embedded in celloidin, cut in the coronal plane and the
following morphometric measures assessed: microgyric volume, medial
geniculate nucleus (MGN) volume, cell number, and cell size, and, as a
control, dorsal lateral geniculate nucleus (dLGN) volume, cell number and
cell size. There were no sex differences in the cortical pathology of
lesioned animals. However, microgyric males had more small and fewer large
neurons in the MGN than their sham-operated counterparts, whereas there was
no difference between lesioned and sham-operated females. There was no
effect on dLGN cell size distribution in either sex. Microgyric males were
significantly impaired in fast auditory temporal processing when compared
to control males, whereas lesioned females exhibited no behavioral
deficits. These results suggest that early injury to the cerebral cortex
may have different effects on specific thalamic nuclei in males and
females, with corresponding differences in behavioral effects.
相似文献
68.
Pond GD; Seeley GW; Ovitt TW; Chernin MM; Yoshino MT; Roehrig H; McIntyre KE 《Radiology》1989,170(2):367-370
This prospective study compared images obtained with a photostimulable imaging plate with matched images obtained with a conventional screen-film combination in 26 patients undergoing intraoperative arteriography. Diagnostic accuracy of the two techniques was assessed objectively, and image quality was assessed subjectively. In 16 patients (62%), the radiation exposure was reduced by 50% for the imaging plate technique by decreasing the mAs level generally used for the screen-film combination. Because of the dynamic range of the imaging plate system, no repeat examinations were necessary, while 12% of the screen-film studies had to be repeated because of over- or under-penetration. Imaging plate studies required 6% more time for processing than screen-film studies. Receiver-operating-characteristic analysis indicated no difference in diagnostic accuracy between the two imaging techniques. Subjective evaluation also revealed no difference in observer preference for imaging plate or screen-film studies. The imaging plate technique is an excellent alternative to screen-film studies in the operating room. 相似文献
69.
70.
Mediastinal Hodgkin disease in children: response to therapy 总被引:1,自引:0,他引:1