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排序方式: 共有2226条查询结果,搜索用时 15 毫秒
21.
Omoto M Imai T Seki K Nomura R Otahara Y 《Environmental health and preventive medicine》1997,2(3):105-116
Based on the fact that chemical products such as binding agents are produced by mixing three kinds of phosphates with different
ratios, we mixed metaphosphate, polyphosphate and pyrophosphate. Each was made to Na-phosphate, K-phosphate, and Ca-phosphate
and each was mixed with commercial feeds so that the content of P would be approximately 0.1, 0.15, 0.3, 0.4, 0.6 and 1.0%.
The prepared pellets were given to ICR, CF # 1 and AKR strains of mice at 29 days of age for 680 days and observations were
made through this experimental period at different stages. The observations were also carried out on the mice administered
with the experimental feeds for 1.5 months from 9 to 10.5 months of age. The observations were compared with those of the
control group at all times. As a result, plasma 1 α, 25 (OH)2 D3 and P levels were always significantly higher in the phosphate administered groups relative to the control. Urine P and Fe
increased while urine Ca decreased in the phosphate-treated groups.
The effect of phosphates on the bones was studied taking soft X-ray pictures of hind legs and applying microdensitometry to
them. Through these observations we recognized thinning of the cortex of bones, reduction of marrow trabecules and development
of osteophyte. Histological observations disclosed that changes in knee joint tissues were apparent; that is, a decrease in
or an irregular loss of the number of cells in superficial, intermediate, and radial strata of the joint cartilage, proliferation
of subchondral bone, and the development of osteophytes were noted. As for muscles, diameters of musclar fibers became smaller;
in particular, type II fibers showed greater shrinkage. Regarding kidneys, swelling and atrophy of glomerular capillaries,
proliferation of mesangial cells, nephroselerosis, swelling, thinning, and loss of tubular epithelium, interstitial tissue
inflammation, development of cylindruria, and deposition of calcium were observed. All these changes seem to be a particularly
advanced aspect of the changes which are more pronounced with increasing dose and age.
These changes were found even in the group administered with the feed containing 0.1% phosphorus, and, these changes were
dependent on the concentration level of P. It was observed that administration to older subjects for a short term (1.5 months)
produced effects stronger than those to younger subjects administered for a long term (10.5 months).
The effects of condensed Ca-phosphate on bones were similar to those of condensed Na- and K-phosphates, and, hence, it was
supposed that these effects were caused by phosphate radicals.
An erratum to this article is available at . 相似文献
22.
Osamu Mikami Shigenari Kawakita Kumiko Fujise Koh Shingu Hakuo Takahashi Tadashi Matsuda 《The Journal of urology》1996,155(4):1368-1371
Purpose
We evaluated plasma catecholamine levels during pneumoperitoneum in laparoscopic surgery.Materials and Methods
Plasma epinephrine and norepinephrine were evaluated in 29 patients who underwent laparoscopic retroperitoneal surgery in a half lateral decubitus position (group 1) or laparoscopic varicocelectomy in a Trendelenburg position (group 2).Results
The levels of epinephrine and norepinephrine increased significantly 5 minutes after carbon dioxide insufflation compared to levels after Veress needle insertion and just before insufflation. The elevation of catecholamine levels during laparoscopic procedures was greater in group 1.Conclusions
Our results indicate that carbon dioxide insufflation may cause catecholamine release during laparoscopic surgery. Careful monitoring of hemodynamics is mandatory at the beginning of the procedure. 相似文献23.
Takashi Yamaguchi Min Gi Shotarou Yamano Masaki Fujioka Kumiko Tatsumi Satoko Kawachi Naomi Ishii Kenichiro Doi Anna Kakehashi Hideki Wanibuchi 《Experimental and toxicologic pathology》2017,69(1):1-7
Diphenylarsinic acid (DPAA), a chemical warfare-related neurotoxic organic arsenical, is present in the groundwater and soil in some regions of Japan due to illegal dumping after World War II. The purpose of the present study was to evaluate the potential toxicity of DPAA when administered to rats in their drinking water for 52 weeks. DPAA was administered to groups 1–4 at concentrations of 0, 5, 10, and 20 ppm in their drinking water for 52 weeks. There were no significant differences in the final body weights between the control groups and the treatment groups in male or female rats. In serum biochemistry, in females 20 ppm DPAA significantly increased alkaline phosphatase and γ-glitamyl transferase compared to controls, and 10 and 20 ppm DPAA significantly increased total cholesterol compared to controls. Absolute and relative liver weights were significantly increased in females treated with 20 ppm DPAA compared to the control group. Dilation of the common bile duct outside the papilla of Vater and stenosis of the papilla of Vater was observed in all male and female rats administered 20 ppm DPAA. The incidence of intrahepatic bile duct hyperplasia was significantly increased in male and female rats treated with 20 ppm DPAA compared to the control groups. These results suggest that DPAA is toxic to the bile duct epithelium in rats. The no-observed adverse effect levels of DPAA were estimated to be 10 ppm (0.48 mg/kg b.w./day) for males and 5 ppm (0.35 mg/kg b.w./day) for females under the conditions of this study. 相似文献
24.
Tomohisa Furuya Satoru Sugimoto Chie Kurokawa Shuichi Ozawa Kumiko Karasawa Keisuke Sasai 《Journal of radiation research》2013,54(1):157-165
To evaluate the dosimetric impact of respiratory breast motion and daily setup error on whole breast irradiation (WBI) using three irradiation techniques; conventional wedge (CW), field-in-field (FIF) and irregular surface compensator (ISC). WBI was planned for 16 breast cancer patients. The dose indices for evaluated clinical target volume (CTVevl), lung, and body were evaluated. For the anterior-posterior (AP) respiratory motion and setup error of a single fraction, the isocenter was moved according to a sine function, and the dose indices were averaged over one period. Furthermore, the dose indices were weighted according to setup error frequencies that have a normal distribution to model systematic and random setup error for the entire treatment course. In all irradiation techniques, AP movement has a significant impact on dose distribution. CTVevlD95 (the minimum relative dose that covers 95 % volume) and V95 (the relative volume receiving 95 % of the prescribed dose) were observed to significantly decrease from the original ISC plan when simulated for the entire treatment course. In contrast, the D95, V95 and dose homogeneity index did not significantly differ from those of the original plans for FIF and CW. With regard to lung dose, the effect of motion was very similar among all three techniques. The dosimetric impact of AP respiratory breast motion and setup error was largest for the ISC technique, and the second greatest effect was observed with the FIF technique. However, these variations are relatively small. 相似文献
25.
26.
Misato Yokose Kohei Furuya Masayuki Suzuki Tadashi Ozawa Younhee Kim Kumiko Miura 《Neuro-ophthalmology (Aeolus Press)》2018,42(5):309-311
Vertical gaze palsy is rarely a neurological symptom, although it has been observed in some cases. Here, we report the case of a patient presenting with complete upward and downward gaze palsy. In this case, a small lesion in the left rostral midbrain was observed on diffusion-weighted magnetic resonance (MR) images, and the lesion was considered to cause the ocular symptom. We consider that vertical gaze palsy is an important clue to an accurate topical diagnosis of a brain lesion. 相似文献
27.
28.
Koichiro Takahashi Hironori Sadamatsu Kumiko Suzuki Hiroki Tashiro Shinya Kimura Yuichiro Kuratomi Naoko Sueoka-Aragane 《Respiratory investigation》2021,59(1):126-134
BackgroundEosinophilic chronic rhinosinusitis (ECRS) is often complicated by asthma and can be difficult to diagnose. This study aimed to clarify the usefulness of the self-administered odor questionnaire (SAOQ) and visual analog scale (VAS) to identify olfactory disorders in patients with asthma.MethodsThis retrospective study was conducted on patients with asthma who were referred to the Otolaryngology clinic between May and September 2018. The treatment step of asthma, asthma control test (ACT), pulmonary function test, peripheral blood eosinophils, and fractional exhaled nitric oxide (FeNO) were analyzed. ECRS was diagnosed based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study score. Olfactory dysfunction was evaluated using the SAOQ and VAS for olfactory disorders.ResultsThe study included 56 patients (18 males and 38 females), who were divided into two groups; those with ECRS (n = 18) and those without ECRS (n = 38). Age, sex, treatment step, ACT score, and pulmonary function were not significantly different between the groups. The ECRS group had a significantly higher FeNO value (89.1 ppb vs. 39.1 ppb) and a significantly lower SAOQ score (40.1% vs. 96.1%). The area under the receiver operating characteristic curve for the efficacy of ECRS diagnosis was 0.88, 0.889, 0.799, and 0.757 for SAOQ, VAS, blood eosinophil count, and FeNO, respectively.ConclusionThe SAOQ and VAS scores were useful tools that presented similar results to the blood eosinophil count and FeNO, and may help to improve the diagnosis of ECRS in patients with asthma. 相似文献
29.
Nishikawa K Matsuoka K Watanabe M Igai K Hino K Hatano K Yamada A Abe N Terunuma D Kuzuhara H Natori Y 《The Journal of infectious diseases》2005,191(12):2097-2105
Shiga toxin (Stx) is a major virulence factor of Stx-producing Escherichia coli. Recently, we developed a therapeutic Stx neutralizer with 6 trisaccharides of globotriaosyl ceramide, a receptor for Stx, in its dendrimer structure (referred to as "SUPER TWIG [1]6") to function in the circulation. Here, we determined the optimal structure of SUPER TWIG for it to function in the circulation and identified a SUPER TWIG with 18 trisaccharides, SUPER TWIG (2)18, as another potent Stx neutralizer. SUPER TWIGs (1)6 and (2)18 shared a structural similarity, a dumbbell shape in which 2 clusters of trisaccharides were connected via a linkage with a hydrophobic chain. The dumbbell shape was found to be required for formation of a complex with Stx that enables efficient uptake and degradation of Stx by macrophages and, consequently, for potent Stx-neutralizing activity in the circulation. We also determined the binding site of the SUPER TWIGs on Stx. 相似文献
30.
Shinohara K Adachi M Matsui K Matsuda K Nagaya S Morishita E 《International journal of hematology》2008,87(3):256-259
The patient, a 20-year-old male, was found to have a slightly prolonged prothrombin time (PT). No episodes of bleeding were
noted. The measurement of coagulation factors revealed that the level of factor X (FX) activity was solely deficient, 51%
(normal range: 70–130% ), and that of FX antigen was 100%. Analysis of the entire FX gene revealed the novel missense mutation
of GTG to ATG, resulting in the substitution of the 196th amino acid valine → methionine. The mother and younger brother had a normal
PT time and expressed no episode of bleeding. The mother exhibited a normal level of FX activity and antigen; however the
younger brother showed a slight decrease in both the parameters. This mutation was not observed in the mother and younger
brother. Polymorphism is not observed at this point in healthy persons. The present novel FX mutation was named FX Hofu. 相似文献