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排序方式: 共有423条查询结果,搜索用时 15 毫秒
71.
Cerebral microgyria, thalamic cell size and auditory temporal processing in male and female rats 总被引:4,自引:2,他引:2
Herman AE; Galaburda AM; Fitch RH; Carter AR; Rosen GD 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(5):453-464
Induction of microgyria by freezing injury to the developing somatosensory
cortex of neonatal rats causes a defect in fast auditory processing in
males, but not in females. It was speculated that early damage to the
cortex has sexually dimorphic cascading effects on other brain regions
mediating auditory processing, which can lead to the observed behavioral
deficits. In the current series of experiments, bilateral microgyri were
induced by placement of a freezing probe on the skulls of newborn male and
female rats, and these animals were tested in adulthood for auditory
temporal processing. Control animals received sham surgery. The brains from
these animals were embedded in celloidin, cut in the coronal plane and the
following morphometric measures assessed: microgyric volume, medial
geniculate nucleus (MGN) volume, cell number, and cell size, and, as a
control, dorsal lateral geniculate nucleus (dLGN) volume, cell number and
cell size. There were no sex differences in the cortical pathology of
lesioned animals. However, microgyric males had more small and fewer large
neurons in the MGN than their sham-operated counterparts, whereas there was
no difference between lesioned and sham-operated females. There was no
effect on dLGN cell size distribution in either sex. Microgyric males were
significantly impaired in fast auditory temporal processing when compared
to control males, whereas lesioned females exhibited no behavioral
deficits. These results suggest that early injury to the cerebral cortex
may have different effects on specific thalamic nuclei in males and
females, with corresponding differences in behavioral effects.
相似文献
72.
Pond GD; Seeley GW; Ovitt TW; Chernin MM; Yoshino MT; Roehrig H; McIntyre KE 《Radiology》1989,170(2):367-370
This prospective study compared images obtained with a photostimulable imaging plate with matched images obtained with a conventional screen-film combination in 26 patients undergoing intraoperative arteriography. Diagnostic accuracy of the two techniques was assessed objectively, and image quality was assessed subjectively. In 16 patients (62%), the radiation exposure was reduced by 50% for the imaging plate technique by decreasing the mAs level generally used for the screen-film combination. Because of the dynamic range of the imaging plate system, no repeat examinations were necessary, while 12% of the screen-film studies had to be repeated because of over- or under-penetration. Imaging plate studies required 6% more time for processing than screen-film studies. Receiver-operating-characteristic analysis indicated no difference in diagnostic accuracy between the two imaging techniques. Subjective evaluation also revealed no difference in observer preference for imaging plate or screen-film studies. The imaging plate technique is an excellent alternative to screen-film studies in the operating room. 相似文献
73.
74.
Mediastinal Hodgkin disease in children: response to therapy 总被引:1,自引:0,他引:1
75.
Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells 总被引:3,自引:0,他引:3
Chevalier S; Praloran V; Smith C; MacGrogan D; Ip NY; Yancopoulos GD; Brachet P; Pouplard A; Gascan H 《Blood》1994,83(6):1479-1485
The expression of the low-affinity NGF receptor (p75) and the trkA proto-oncogene product was analyzed in a series of human hematopoietic cell lines at protein and RNA levels. We did not detect any form of NGF receptor in cell lines displaying a myelomonocytic phenotype (HL60 and U937). In contrast, cells displaying a more immature erythroleukemic phenotype (TF1 and K562) expressed TrkA in the absence of detectable p75. Scatchard analysis showed a single high-affinity site for NGF (kd = 10(-10) mol/L), with a copy number ranging from 300 to 3,000 sites per cell depending on the studied cell line. In addition, NGF induced autophosphorylation of TrkA and could substitute for granulocyte- monocyte colony-stimulating factor to trigger the proliferation of the TF1 cell line, with a half-maximal signal observed at 50 pmol/L, indicating that p75 is not required for DNA synthesis in this cell line. The physiologic relevance of NGF in early hematopoiesis was confirmed by showing that 12% to 15% of progenitor blood cells from mice treated with 5-fluorouracil expressed TrkA and that these cells could be induced to proliferate and differentiate in response to NGF in association with macrophage colony-stimulating factor. Our study demonstrates for the first time that trkA proto-oncogene expression and activation is not restricted to the nervous system, but is also an important element in early hematopoiesis. 相似文献
76.
77.
Christina Q. Nguyen Dr Didu S. T. Kariyawasam Dr PhD Tsz Shun Jason Ngai Dr James Nguyen Dr Kristine Alba-Concepcion Dr MD MPH Sarah E. Grattan GD Psych Ms Elizabeth E. Palmer Dr PhD Kate Hetherington Dr PhD Claire E. Wakefield PhD Russell C. Dale PhD Sue Woolfenden PhD Shekeeb Mohammad PhD Michelle A. Farrar PhD 《Health expectations》2024,27(3):e14063
78.
Goto Y O'Malley C Fanning NF Wang J Redmond HP Shorten GD 《Irish journal of medical science》2003,172(4):191-194
Background Benzodiazepines, which are commonly administered perioperatively, can depress immune function. Neutrophil apoptosis plays
a central role in the regulation of inflammation. This is particularly important during and after surgery.
Aim To examine the effects of benzodiazepines (midazolam and diazepam) on neutrophil apoptosis.
Methods Venous blood samples were withdrawn from patients scheduled to undergo elective surgery, (a) immediately prior to, and 10
minutes after administration of midazolam 0.2mg/kg intravenously (n=11) and (b) immediately prior to, and 60 minutes after
administration of diazepam 10mg po (n=10). Neutrophil apoptosis was measured by Annexin VFITC after 1 and 12 hours in culture.
Results The percentage of apoptotic cells was significantly less after midazolam at 12% (11.9) hours in culture compared to pre-midazolam
29.7% (13.3) (p<0.05). After diazepam, the rates of neutrophil apoptosis were also significantly less after 12 hours in culture
(p<0.05).
Conclusion Administration of benzodiazepines in clinically relevant doses inhibits neutrophil apoptosis. In the perioperative period,
this may influence the inflammatory response to surgery. 相似文献
79.
80.
Snyder DS; Chao NJ; Amylon MD; Taguchi J; Long GD; Negrin RS; Nademanee AP; O'Donnell MR; Schmidt GM; Stein AS 《Blood》1993,82(9):2920-2928
Ninety-nine consecutive patients with acute leukemia in first complete remission under age 50 (median age 27 years; age range 1 to 47 years) with a histocompatible sibling donor were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation. Sixty-one patients were diagnosed with acute myelogenous leukemia (AML), 34 patients with acute lymphoblastic leukemia (ALL), 3 patients with biphenotypic acute leukemia, and 1 patient with acute undifferentiated leukemia. Thirty of the 34 patients with ALL had at least one of the following high-risk factors: age greater than 30, white blood cell count at presentation > 25,000/microL, extramedullary disease, certain chromosomal translocations, or the need for greater than 4 weeks of induction chemotherapy to achieve first complete remission. Cumulative probabilities of disease-free survival and relapse at 3 years were 61% and 12%, respectively, for the 61 patients with AML and 64% and 12%, respectively, for the 34 patients with ALL. By stepwise Cox regression analysis, significant prognostic variables for patients with acute myelogenous leukemia were the presence of acute graft-versus-host disease and increasing age, whereas for patients with acute lymphoblastic leukemia, significant variables were age and the development of cytomegalovirus-associated interstitial pneumonia. Complications related to graft-versus-host disease and relapse of leukemia were the major causes of death. 相似文献