全文获取类型
收费全文 | 18363篇 |
免费 | 1533篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 155篇 |
儿科学 | 518篇 |
妇产科学 | 516篇 |
基础医学 | 2531篇 |
口腔科学 | 605篇 |
临床医学 | 2126篇 |
内科学 | 3295篇 |
皮肤病学 | 429篇 |
神经病学 | 1707篇 |
特种医学 | 911篇 |
外科学 | 2322篇 |
综合类 | 484篇 |
一般理论 | 17篇 |
预防医学 | 2000篇 |
眼科学 | 228篇 |
药学 | 1143篇 |
1篇 | |
中国医学 | 18篇 |
肿瘤学 | 930篇 |
出版年
2022年 | 141篇 |
2021年 | 265篇 |
2020年 | 202篇 |
2019年 | 310篇 |
2018年 | 358篇 |
2017年 | 273篇 |
2016年 | 264篇 |
2015年 | 300篇 |
2014年 | 422篇 |
2013年 | 634篇 |
2012年 | 838篇 |
2011年 | 835篇 |
2010年 | 544篇 |
2009年 | 484篇 |
2008年 | 717篇 |
2007年 | 752篇 |
2006年 | 693篇 |
2005年 | 705篇 |
2004年 | 698篇 |
2003年 | 671篇 |
2002年 | 647篇 |
2001年 | 612篇 |
2000年 | 672篇 |
1999年 | 569篇 |
1998年 | 272篇 |
1997年 | 225篇 |
1996年 | 257篇 |
1995年 | 198篇 |
1994年 | 177篇 |
1993年 | 174篇 |
1992年 | 440篇 |
1991年 | 409篇 |
1990年 | 410篇 |
1989年 | 386篇 |
1988年 | 330篇 |
1987年 | 346篇 |
1986年 | 302篇 |
1985年 | 308篇 |
1984年 | 285篇 |
1983年 | 240篇 |
1982年 | 143篇 |
1980年 | 143篇 |
1979年 | 200篇 |
1978年 | 152篇 |
1976年 | 132篇 |
1975年 | 144篇 |
1974年 | 143篇 |
1973年 | 145篇 |
1972年 | 149篇 |
1971年 | 116篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
M M O'Kane P A King H D Edmondson 《International journal of oral and maxillofacial surgery》1986,15(4):422-424
Button wiring has been used as an alternative to eyelet wiring in the Department of Oral and Dental Surgery of Birmingham General Hospital since 1977. This clinical update reviews 65 patients with mandibular fractures in which button wires were utilised in their treatment. 相似文献
12.
Tolerance of ocular iontophoresis in healthy volunteers. 总被引:4,自引:0,他引:4
Thomas M Parkinson Elizabeth Ferguson Salvatore Febbraro Arash Bakhtyari Martin King Mohan Mundasad 《Journal of ocular pharmacology and therapeutics》2003,19(2):145-151
To evaluate ocular tolerance, healthy volunteers were iontophoresed transclerally using novel OcuPhor trade mark hydrogel drug delivery applicators filled with balanced salt solution. In this three-period crossover study in 24 male and female subjects, 16 subjects received 0 mA and two of the following DC currents: 0.1, 0.5., 1.0, 2.0, 3.0, or 4.0 mA for 20 min; 6 subjects received 3 mA for 20 min and 1.5 mA for 40 min (both equivalent to 60 mAmin total charge). Safety and tolerance were determined by subjective VAS and objective ophthalmic assessments. Subjects were evaluated before and up to 22 hr after dosing. The applicators were well-tolerated and no clinically significant changes in symptomology or in ophthalmic assessments were seen following exposure to 0-3.0 mA for 20 min or 1.5 mA for 40 min. At 4.0 mA 2 of 4 subjects reported a burning sensation under the applicator during dosing which resolved by 22 hr post-dose; superficial changes in fluorescein staining were observed at 1 hr, but not at 22 hr. The OcuPhor trade mark system has promise for noninvasive drug delivery to the eye. 相似文献
13.
Assessment of quality of life in children with peanut allergy 总被引:5,自引:0,他引:5
Natalie J. Avery Rosemary M. King Susan Knight Jonathan O'B. Hourihane 《Pediatric allergy and immunology》2003,14(5):378-382
Children with a peanut allergy (PA) are faced with food and social restrictions due to the potentially life-threatening nature of their disease, for which there is no cure or treatment. This inevitably impacts upon their quality of life (QoL). QoL of 20 children with PA and 20 children with insulin-dependent diabetes mellitus (IDDM) was measured using two disease-specific QoL questionnaires (higher scores correspond to a poorer QoL). One questionnaire was designed by us and the other was adapted from the Vespid Allergy QoL questionnaire. We gave subjects cameras to record how their QoL is affected over a 24-h period. Response rates for both questionnaires were 100%. Mean ages were 9.0 and 10.4 years for PA and IDDM subjects, respectively. Children with a PA reported a poorer quality of life than children with IDDM: mean scores were 54.85 for PA subjects and 46.40 for diabetics (p = 0.004) in questionnaire 1 and 54.30 and 34.50 (p≤0.001) in questionnaire 2. PA children reported more fear of an adverse event and more anxiety about eating, especially when eating away from home. Photographs fell into seven common categories: food, management, environment, away from home, physical activities, restaurant and people. Most photographs related to food and management issues and revealed difficulties for both groups regarding food restrictions. PA subjects felt more threatened by potential hazards within their environment, felt more restricted by their PA regarding physical activities, and worried more about being away from home. However, they felt safe when carrying epinephrine kits and were positive about eating at familiar restaurants. The QoL in children with PA is more impaired than in children with IDDM. Their anxiety may be considered useful in some situations, promoting better adherence to allergen avoidance advice and rescue plans. 相似文献
14.
The investigation of AUSTROLIABUM CANDIDUM afforded, in addition to several known sesquiterpene lactones, four new ones, including three germacranolides with an ether bridge, as well as an unusual glucoside. The structures were elucidated by spectroscopic methods. 相似文献
15.
Rosie King 《中华医学信息导报》2005,20(1)
对于ED患者的诊治,第一步应该发现并治疗潜在的伴随性疾病,如,检查空腹血糖和血脂,是否患有影响血流的疾病.检查激素水平,注意并不是每一个患者首次检查都要检测激素水平. 相似文献
16.
17.
M C Nahata D R King D A Powell S M Marx M E Ginn-Pease 《JPEN. Journal of parenteral and enteral nutrition》1988,12(1):58-59
Broviac catheters are commonly used to provide parenteral nutrition and access for infusion of blood products and drugs to pediatric patients. Sepsis is the most common serious complication of continued catheter use. Although removal of the catheter is generally recommended when it becomes contaminated, it may not be feasible to do so without compromising patient care. We evaluated the management of catheter-related infections in pediatric patients with and without removal of catheter. Seventy-seven episodes of catheter sepsis were evaluated in 61 pediatric patients; 24 were neonates and 37 were older children. The catheters were used for multiple purposes in 75% of cases. The most common microorganisms isolated were Staphylococcus epidermidis in 26%, Klebsiella pneumoniae in 9%, and Streptococcus viridans in 8% of cases; other pathogens included group D Enterococcus, Staphylococcus aureus, and Escherichia coli. Pseudomonas aeruginosa was isolated in four older children. Thirty-five patients were treated with antibiotics without catheter removal. Thirty patients received appropriate antibiotic therapy based on the susceptibility data. Twenty-six of these 30 patients responded within 5 days of therapy whereas the others required 15-39 days of treatment. Lack of response was mainly associated with the presence of abscess, immunocompromised status, and organisms P. aeruginosa and Candida albicans. Based on the sensitivity and minimum inhibitory concentration data, a combined regimen of gentamicin and vancomycin would be an effective initial therapy. These findings suggest that (1) catheter sepsis can be managed with appropriate antibiotics, and (2) when continued use of Broviac catheter is desired, a trial of antibiotic therapy should be attempted before catheter removal. 相似文献
18.
Eileen J. Martin Kiran S. Panickar Michael A. King Malgorzata Deyrup Bruce E. Hunter Geehuan Wang Edwin M. Meyer 《Drug development research》1994,31(2):135-141
The potential cytoprotective actions of a novel nicotinic agent 2,4-dimethoxybenzilidene anabaseine (DMXB) were investigated in differentiated PC12 cells and transected rat septal cholinergic neurons in vivo. In NGF-differentiated PC12 cells, removal of both NGF and serum led to cell loss, a reduced % of cells expressing neurites, the release of lactate dehydrogenase, and a decrease in total cellular protein. Cell loss was apparent within 24 h, and remained constant between 4–8 days post-NGF removal. NGF alone (100 ng/ml), DMXB (10 μM), but not nicotine (10 μM), prevented these cell and neurite losses. DMXB-induced cytoprotection was blocked by 1 μM mecamylamine. DMXB (1 mg/kg, ip) injected twice but not once per day protected cholinesterase-staining septal neurons from retrograde degeneration following unilateral fimbrial transections. The twice per day DMXB injection-protocol also decreased cell roundness among cholinesterase-staining cells in the lesioned septal hemisphere compared to saline-injected animals. These studies suggest that DMXB may exert cytoprotective activity in NGF-sensitive neuronal populations. © 1994 Wiley-Liss, Inc. 相似文献
19.
High-level language functioning was assessed in a group of 11 children with severe closed head injury (CHI). Performance was examined on measures of figurative language, oral expression, inferencing, and interpretation of ambiguous sentences, and was compared with that of a control group matched for age, gender, and handedness. The children with CHI demonstrated inferior performance on the oral expression, ambiguous sentences, and figurative language tests; however, performance on the inferencing task appeared intact. These findings are discussed with respect to the underlying nature of the observed impairments. Both linguistic and cognitive factors are considered. It is concluded that a complex interaction of cognitive and linguistic impairments experienced by children with CHI may underlie the performance deficits identified in the current study. 相似文献
20.
C G Fraser S P Wilkinson R G Neville J D Knox J F King R S MacWalter 《American journal of clinical pathology》1989,92(4):465-470
Analytic, within-subject, and between-subject biologic variations were estimated for leukocytes, erythrocytes, hemoglobin, hematocrit, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin content (MCHC), platelets, and a three-component differential count (lymphocytes, monocytes, and granulocytes in terms of both concentration and percentage of leukocytes) in cohorts of 12 male and 12 female healthy elderly subjects. The assays were performed with an Ortho ELT-800 automated analyzer. The estimates of within-subject biologic variation were similar to published data on young subjects, indicating that this aspect of homeostasis is not compromised in the elderly. The data were used to derive objective analytic goals; goals were surpassed except for assays of erythrocytes, hematocrit, and the derived MCV, MCH, and MCHC. The changes required for serial results to be significantly different were determined and found to be generally valid because most quantities have no heterogeneity of within-subject variation. All quantities had significant individuality; in consequence, conventional population-based reference values are of limited utility, and screening using reference limits will not detect latent or early disease in many subjects. 相似文献