全文获取类型
收费全文 | 1381195篇 |
免费 | 100954篇 |
国内免费 | 2655篇 |
专业分类
耳鼻咽喉 | 18163篇 |
儿科学 | 42701篇 |
妇产科学 | 36660篇 |
基础医学 | 208094篇 |
口腔科学 | 37600篇 |
临床医学 | 128661篇 |
内科学 | 268554篇 |
皮肤病学 | 30969篇 |
神经病学 | 111329篇 |
特种医学 | 53416篇 |
外国民族医学 | 265篇 |
外科学 | 193747篇 |
综合类 | 26236篇 |
现状与发展 | 6篇 |
一般理论 | 594篇 |
预防医学 | 110858篇 |
眼科学 | 31044篇 |
药学 | 103308篇 |
6篇 | |
中国医学 | 3439篇 |
肿瘤学 | 79154篇 |
出版年
2021年 | 13607篇 |
2019年 | 12752篇 |
2018年 | 16933篇 |
2017年 | 13129篇 |
2016年 | 14998篇 |
2015年 | 18224篇 |
2014年 | 24097篇 |
2013年 | 34563篇 |
2012年 | 48148篇 |
2011年 | 50069篇 |
2010年 | 28887篇 |
2009年 | 27225篇 |
2008年 | 44733篇 |
2007年 | 47010篇 |
2006年 | 45903篇 |
2005年 | 44694篇 |
2004年 | 42361篇 |
2003年 | 40138篇 |
2002年 | 38471篇 |
2001年 | 58469篇 |
2000年 | 59291篇 |
1999年 | 49870篇 |
1998年 | 14204篇 |
1997年 | 12825篇 |
1996年 | 13091篇 |
1995年 | 12321篇 |
1994年 | 11440篇 |
1992年 | 38829篇 |
1991年 | 38248篇 |
1990年 | 36963篇 |
1989年 | 35701篇 |
1988年 | 33073篇 |
1987年 | 32409篇 |
1986年 | 30792篇 |
1985年 | 29072篇 |
1984年 | 22147篇 |
1983年 | 19339篇 |
1982年 | 11469篇 |
1979年 | 21124篇 |
1978年 | 15520篇 |
1977年 | 12886篇 |
1976年 | 11957篇 |
1975年 | 12913篇 |
1974年 | 15705篇 |
1973年 | 15460篇 |
1972年 | 14590篇 |
1971年 | 13623篇 |
1970年 | 12844篇 |
1969年 | 12114篇 |
1968年 | 11278篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
121.
James L. Dorling Alice E. Thackray James A. King Andrea Pucci Fernanda R. Goltz Rachel L. Batterham David J. Stensel 《Nutrients》2020,12(12)
The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is linked to obesity and dyslipidemia, yet the independent influence of this polymorphism on blood lipids remains equivocal. We examined the influence of the FTO rs9939609 polymorphism on fasting and postprandial blood lipids in individuals homozygous for the risk A-allele or T-allele with similar anthropometric and demographic characteristics. 12 AA and 12 TT males consumed a standardized meal after fasting overnight. Blood samples were collected at baseline (−1.5 h), before the meal (0 h), and for five hours postprandially to measure lipid, glucose, and insulin concentrations. Time-averaged total area under the curve (TAUC) values (0–5 h) were calculated and compared between genotypes. Fasting triacylglycerol (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, non-esterified fatty acid (NEFA), glucose, and insulin concentrations were similar between groups (p ≥ 0.293). TAUC for TG was similar in AAs and TTs (95% confidence interval (CI) −0.52 to 0.31 mmol/L/h; p = 0.606). Likewise, TAUC values were similar for NEFA (95% CI −0.04 to 0.03 mmol/L/h; p = 0.734), glucose (95% CI −0.41 to 0.44 mmol/L/h; p = 0.951), and insulin (95% CI −6.87 to 2.83 pmol/L/h; p = 0.395). Blood lipids are not influenced by the FTO rs9939609 polymorphism, suggesting the FTO-dyslipidemia link is mediated by adiposity and weight management is important in preventing FTO-related lipid variations. 相似文献
122.
123.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse 下载免费PDF全文
124.
125.
126.
127.
C. Jacquet F. Goehringer E. Baux J.A. Conrad M.O. Ganne Devonec J.L. Schmutz G. Mathey H. Tronel T. Moulinet I. Chary-Valckenaere T. May C. Rabaud 《Médecine et maladies infectieuses》2019,49(2):112-120
Objective
The teaching hospital of Nancy, France, implemented a specific multidisciplinary care pathway (French acronym AMDPL) to improve the management of patients presenting with Lyme borreliosis (LB) suspicion. We aimed to assess the first year of activity of this care pathway.Patients and methods
We included all patients managed in the AMDPL pathway from November 1, 2016 to October 31, 2017. The first step was a dedicated Lyme disease consultation with an infectious disease specialist. Following this consultation, the LB diagnosis was either confirmed and adequate treatment was prescribed, or a differential diagnosis was established and patients received adequate management, or further investigations were required and patients were offered multidisciplinary management as part of a day hospitalization.Results
A total of 468 patients were included. LB diagnosis was confirmed in 15% of patients (69/468), 49% of patients received a differential diagnosis, and 26% (122/468) of patients had the LB diagnosis ruled out without receiving any other diagnosis.Conclusions
This is to our knowledge the first multidisciplinary center implemented in France for the management of patients presenting with LB suspicion related to polymorphous signs and symptoms. Several diagnoses could be confirmed or corrected, although some symptoms and complaints could not be explained. This cohort could improve our knowledge of LB and its differential diagnoses. 相似文献128.
129.
130.
Samo Lasi
Filip Szczepankiewicz Erica Dall'Armellina Arka Das Christopher Kelly Sven Plein Jürgen E. Schneider Markus Nilsson Irvin Teh 《NMR in biomedicine》2020,33(2)
Motion is a major confound in diffusion‐weighted imaging (DWI) in the body, and it is a common cause of image artefacts. The effects are particularly severe in cardiac applications, due to the nonrigid cyclical deformation of the myocardium. Spin echo‐based DWI commonly employs gradient moment‐nulling techniques to desensitise the acquisition to velocity and acceleration, ie, nulling gradient moments up to the 2nd order (M2‐nulled). However, current M2‐nulled DWI scans are limited to encode diffusion along a single direction at a time. We propose a method for designing b‐tensors of arbitrary shapes, including planar, spherical, prolate and oblate tensors, while nulling gradient moments up to the 2nd order and beyond. The design strategy comprises initialising the diffusion encoding gradients in two encoding blocks about the refocusing pulse, followed by appropriate scaling and rotation, which further enables nulling undesired effects of concomitant gradients. Proof‐of‐concept assessment of in vivo mean diffusivity (MD) was performed using linear and spherical tensor encoding (LTE and STE, respectively) in the hearts of five healthy volunteers. The results of the M2‐nulled STE showed that (a) the sequence was robust to cardiac motion, and (b) MD was higher than that acquired using standard M2‐nulled LTE, where diffusion‐weighting was applied in three orthogonal directions, which may be attributed to the presence of restricted diffusion and microscopic diffusion anisotropy. Provided adequate signal‐to‐noise ratio, STE could significantly shorten estimation of MD compared with the conventional LTE approach. Importantly, our theoretical analysis and the proposed gradient waveform design may be useful in microstructure imaging beyond diffusion tensor imaging where the effects of motion must be suppressed. 相似文献