Neuroendocrine-immune disorder in type 2 diabetic patients with retinopathy

1. Diabetes mellitus is usually accompanied by hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis. Diabetic retinopathy is one of the most devastating complications in diabetes although little is known with regards to the HPA activity in type 2 diabetic patients (T2DM) with diabetic retinopathy. The present study was designed to evaluate the HPA axis activity in type 2 diabetic patients with diabetic retinopathy. 2. Diabetic retinopathy was examined by fluorescein fundus angiography (FFA) in 174 consecutive type 2 diabetic patients. Levels of / were measured using flow cytometry. Serum concentrations of interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), adrenocorticotrophic hormone (ACTH) and cortisone were measured by radioimmunoassay. Plasma levels of monoamines norepinephrine (NE) and dopamine (DA) were assessed using high performance liquid chromatograph equipped with a fluorescence detection. Patients were grouped into the non-diabetic retinopathy (NDR), non-proliferating diabetic retinopathy (NPR) and proliferating diabetic retinopathy (PDR) categories. 3. Patients with PDR showed significantly less than those with NDR and NPR (P<0.05). No significant correlation was found in / and NK or severity of retinopathy among the three patient groups. There was no significant difference in serum IL-1β, IL-6 and TNF-α levels among the different patient groups (P>0.05). The serum concentrations of ACTH and cortisone were lower in PDR patients than other groups. There was no significant difference in plasma concentrations of DA and NE among all three groups (P>0.05). 4. Our data suggest that HPA and immune dysfunction might play a role in the development and/or progression of PDR.     

A case report of endometrial adenocarcinoma with leptomeningeal metastases

In patients with a history of solid tumors, any new onset of neurological symptoms should be assessed for central nervous system involvement even in rare cases such as gynecological malignancies that nervous system involvement is a rare event.     

In vivo molecular imaging of myocardial angiogenesis using the αvβ3 integrin-targeted tracer 99mTc-RAFT-RGD

Background

Myocardial angiogenesis following reperfusion of an infarcted area may impact on patient prognosis and pro-angiogenic treatments are currently evaluated. The non-invasive imaging of angiogenesis would therefore be of potential clinical relevance in these settings. ^99mTc-RAFT-RGD is a novel ^99mTc-labeled tracer that targets the α_vβ₃ integrin. Our objective was to determine whether this tracer was suitable for myocardial angiogenesis imaging.

Methods and Results

A rat model of reperfused myocardial infarction was employed. Fourteen days following reperfusion, the animals were injected with ^99mTc-RAFT-RGD or with its negative control ^99mTc-RAFT-RAD. Fourteen animals were dedicated to autoradiographic imaging, infarct staining, and gamma-well counting of myocardial activity. In vivo dual-isotope pinhole SPECT imaging of ²⁰¹Tl and ^99mTc-RAFT-RGD or ^99mTc-RAFT-RAD was also performed in 11 additional animals. Neovessels were observed by immunostaining in the infarcted and peri-infarct areas. ^99mTc-RAFT-RGD infarct-to-normal ratios by gamma-well counting and ex vivo imaging (2.5 ± 0.6 and 4.9 ± 0.9, respectively) were significantly higher than those of ^99mTc-RAFT-RAD (1.7 ± 0.2 and 2.2 ± 0.4, respectively, P < .05). The infarcted area was readily visible in vivo by SPECT with ^99mTc-RAFT-RGD but not with ^99mTc-RAFT-RAD (infarct-to-normal zone activity ratio, 2.5 ± 0.6 and 1.7 ± 0.4, respectively, P < .05).

Conclusion

^99mTc-RAFT-RGD allowed the experimental in vivo molecular imaging of myocardial angiogenesis.     

The psychometric properties of the Iranian version of revised prenatal coping inventory (Nu PCI) in healthy pregnant women: a confirmatory factor analysis

The Revised Prenatal Coping Inventory (Nu PCI) is a self-report instrument that focuses on the coping styles of pregnant women during the prenatal period. The present study aimed to translate the scale and evaluate the psychometric properties of the Iranian version of the Nu PCI in healthy pregnant women. Beaton’s recommendations have been used for the translation and cultural adaptation of this scale. Reliability, content, and face validity were performed to assess the psychometric properties of the scale. The results indicated that the Nu PCI was successfully translated into the Persian language, with both the total scale and subscales exhibiting both content validity and internal consistency. Confirmatory factor analyses revealed that the conceptual three-factor structure of the measure had good fit indices. Reliability was evaluated using internal consistency. Cronbach Alpha coefficient was 0.92 and intra-class correlation coefficient (ICC) was 0.91. Therefore, the Nu PCI is a reliable instrument to measure prenatal coping patterns in primigravida healthy pregnant women.     

Prediction of high ovarian response to controlled ovarian hyperstimulation: anti-Müllerian hormone versus small antral follicle count (2–6 mm)

Purpose  

To evaluate the predictive value of basal serum anti-müllerian hormone level and small antral follicle count for high ovarian response to controlled ovarian hyperstimulation.     

Spirituality: A key factor in coping among Iranians chronically affected by mustard gas in the disaster of war

The present study aimed to explore the approach used by Iranians chronically affected by mustard gas in the disaster of war to cope with their chronic illness complications. A qualitative approach was adopted using content analysis of unstructured interviews carried out with 20 patients in a medical center in Tehran and an outpatient clinic in the North West of Iran. Two main themes that emerged from the study were "religious sentiment" and "patriotism". The subthemes that emerged were "divine will", "illness as a means of absolving sin", "saying prayers in the anticipation of divine rewards", "defending the motherland" and "self-sacrifice as a source of pride". To sum up, spirituality was recognized as a key factor among the participants in accepting and coping with their chronic illness complications.