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排序方式: 共有183条查询结果,搜索用时 15 毫秒
61.
62.
Kourous A. Rezai Elzbieta Gasyna Brandon-Luke L. Seagle James R. NorrisJr. Kasra A. Rezaei 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2008,246(5):671-676
Purpose The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering
chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated.
Design Laboratory investigation
Clinical relevance Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular
degeneration (AMD).
Methods RPE cells were exposed to blue light (430–450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural
(UV and blue light) filter for 10 days. The rate of apoptosis was analyzed.
Results Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced
apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was
4.25 mW/cm2 and with the AcrySof Natural filter was 2.5 mW/cm2.
Conclusions AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect
on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk
for AMD, the implantation of a blue light-filtering intraocular lens may be considered.
Supported in part by Alcon Laboratories and Research to Prevent Blindness. None of the authors have a proprietary interest. 相似文献
63.
The integrity of the final printed components is mostly dictated by the adhesion between the particles and phases that form upon solidification, which is a major problem in printing metallic parts using available In-Space Manufacturing (ISM) technologies based on the Fused Deposition Modeling (FDM) methodology. Understanding the melting/solidification process helps increase particle adherence and allows to produce components with greater mechanical integrity. We developed a phase-field model of solidification for binary alloys. The phase-field approach is unique in capturing the microstructure with computationally tractable costs. The developed phase-field model of solidification of binary alloys satisfies the stability conditions at all temperatures. The suggested model is tuned for Ni-Cu alloy feedstocks. We derived the Ginzburg-Landau equations governing the phase transformation kinetics and solved them analytically for the dilute solution. We calculated the concentration profile as a function of interface velocity for a one-dimensional steady-state diffuse interface neglecting elasticity and obtained the partition coefficient, k, as a function of interface velocity. Numerical simulations for the diluted solution are used to study the interface velocity as a function of undercooling for the classic sharp interface model, partitionless solidification, and thin interface. 相似文献
64.
65.
Effect of Zoledronate on Bone Quality in the Treatment of Aseptic Loosening of Hip Arthroplasty in the Dog 总被引:1,自引:0,他引:1
Wise LM Waldman SD Kasra M Cheung R Binnington A Kandel RA White LM Grynpas MD 《Calcified tissue international》2005,77(6):367-375
Periprosthetic bone loss, which is a direct cause of aseptic loosening in total hip arthroplasty (THA), can be suppressed
by bisphosphonates. It is unknown how the quality of this bone is affected in the presence of both wear debris (from implant)
and bisphosphonates. The objective of this study was to evaluate the effect of zoledronate (ZLN) on bone quality in the presence
of wear debris [polyethylene (PE) particles] in a canine model of uncemented THA. Thirty dogs underwent THA, and aseptic loosening
was induced via implantation of PE particles packed into the femoral component. For 26 weeks until sacrifice, two groups (each
n = 10) received weekly injections of ZLN (low dose 2 μg/kg, high dose 10 μg/kg) and the third group (control) received saline.
Histological and radiographic examinations were performed to evaluate the degree of implant reaction. Histomorphometry (static/dynamic)
was performed to evaluate bone turnover. Back-scattered electron imaging was used to quantify the newly formed bone and to
evaluate the mineralization distribution. Density fractionation and X-ray diffraction were used to evaluate mineral properties,
while four-point bending was used to determine mechanical properties. A dose-dependent presence of newly formed subperiosteal
bone was found, which appeared to be less mineralized than the adjacent cortical bone. The high-dose ZLN group showed decreased
cortical porosity and turnover and increased mineralization profile, failure strength, and modulus. We conclude that ZLN affects
some of the material properties of cortical bone and allows the newly formed subperiosteal bone to remain and therefore affect
the overall quality of the bone. 相似文献
66.
Cohen CR Koochesfahani KM Meier AS Shen C Karunakaran K Ondondo B Kinyari T Mugo NR Nguti R Brunham RC 《The Journal of infectious diseases》2005,192(4):591-599
Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development. 相似文献
67.
68.
69.
Mohammad Ali Saghiri Abbas Delvarani Payman Mehrvarzfar Mohsen Nikoo Mehrdad Lotfi Kasra Karamifar Kamal Asgar Sahar Dadvand 《Saudi Dental Journal》2011,23(3):149-152
Aim
Cytotoxicity of root canal irrigants is important due to their close contact with host tissues. This study was to assess the possible impact of pH on cytotoxic effects of MTAD, 17% EDTA, and 2.6% NaOCl on the human gingival fibroblasts using MTT assay.Materials and methods
Human gingival fibroblasts were exposed to the irrigants and their viability was assessed after 1, 6, and 12 h. The pH of the medium was measured in each interval. Light absorption values were measured for each culture medium using Elisa Reader device.Results
NaOCl had significantly less cytotoxicity than EDTA and MTAD. Also irrigants cytotoxicity decreased in 12, 1, and 6 h, respectively.Conclusion
It seems that variation of the pH resulted in variation in the cytotoxicity of solutions; i.e., it follows the pattern of the pH variation. 相似文献70.
External invasive resorption is an uncommon but aggressive type of external resorption. This report outlines the management of an advanced case of external invasive resorption with mineral trioxide aggregate (MTA). The clinical and radiographic follow-up after 60 months revealed a functional tooth with a stable periodontal condition and no evidence of any further resorption. 相似文献