全文获取类型
收费全文 | 5932篇 |
免费 | 520篇 |
国内免费 | 234篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 113篇 |
妇产科学 | 80篇 |
基础医学 | 689篇 |
口腔科学 | 190篇 |
临床医学 | 587篇 |
内科学 | 1124篇 |
皮肤病学 | 60篇 |
神经病学 | 282篇 |
特种医学 | 354篇 |
外国民族医学 | 1篇 |
外科学 | 795篇 |
综合类 | 586篇 |
现状与发展 | 2篇 |
预防医学 | 541篇 |
眼科学 | 69篇 |
药学 | 502篇 |
1篇 | |
中国医学 | 204篇 |
肿瘤学 | 459篇 |
出版年
2023年 | 59篇 |
2022年 | 143篇 |
2021年 | 178篇 |
2020年 | 141篇 |
2019年 | 140篇 |
2018年 | 159篇 |
2017年 | 154篇 |
2016年 | 173篇 |
2015年 | 185篇 |
2014年 | 279篇 |
2013年 | 296篇 |
2012年 | 442篇 |
2011年 | 456篇 |
2010年 | 288篇 |
2009年 | 259篇 |
2008年 | 354篇 |
2007年 | 362篇 |
2006年 | 297篇 |
2005年 | 297篇 |
2004年 | 224篇 |
2003年 | 215篇 |
2002年 | 193篇 |
2001年 | 110篇 |
2000年 | 103篇 |
1999年 | 108篇 |
1998年 | 73篇 |
1997年 | 54篇 |
1996年 | 49篇 |
1995年 | 35篇 |
1994年 | 45篇 |
1993年 | 37篇 |
1992年 | 57篇 |
1991年 | 48篇 |
1990年 | 46篇 |
1989年 | 66篇 |
1988年 | 49篇 |
1987年 | 60篇 |
1986年 | 53篇 |
1985年 | 55篇 |
1984年 | 36篇 |
1983年 | 31篇 |
1982年 | 22篇 |
1981年 | 23篇 |
1980年 | 17篇 |
1979年 | 31篇 |
1978年 | 25篇 |
1977年 | 17篇 |
1975年 | 15篇 |
1974年 | 19篇 |
1970年 | 13篇 |
排序方式: 共有6686条查询结果,搜索用时 15 毫秒
31.
Ichinose Y Okino T Yamasaki S Moriguchi Y Sugie T Li L Kanaoka S Kan N Watanabe Y Imamura M 《Surgery today》1999,29(4):338-343
To evaluate the effect of interferon-γ-genetransduced cells, DS mice were inoculated into their footpads with syngeneic mammary
adenocarcinoma SC42 admixed with interferon-γ producing mammary adenocarcinoma SC115Kγ, which had been established by an interferon-γ-gene
transduction in another syngeneic mammary adenocarcinoma SC115 using retroviral vectors. These mice rejected both tumor cells
and developed resistance to subsequent challenges with either SC115 or SC42 cells inoculated into their opposite posterior
footpads. These results thus indicate that systemic immunological memory to each of the independent tumor cell lines developed
in these mice. Although the SC42 cells admixed with irradiated SC115Kγ cells were rejected by these mice, the SC42 cells admixed
with irradiated SC115neoR, in which the neo-gene had been transduced, were observed to proliferate. Tumor rejection was reversed
by an in vivo administration of anti-interferon-γ antibody, thus suggesting that locally produced interferon-γ plays an important
role in tumor elimination and immunological memory induction. In conclusion, interferon-γ-gene-transduced tumor cells are
therefore considered to have a therapeutic potential for other types of malignant tumor cell lines. 相似文献
32.
Eighty four out of 2151 militancy trauma patients sustained severe maxillofacial injury from Jan 1990 to March 1993. The resuscitation, stabilisation and intensive care of these patients was based on management priorities of primary resuscitation, care of airway, management of haemodynamics, oxygenation and monitoring. Anaesthesia was administered in a situation when the airway was likely to be compromised and the patients were critically sick. Initial ventilation and oxygenation was the most difficult and could be achieved with satisfactory seal around the face mask by applying water-soaked guaze pieces around the mouth and nose to “fill-in” the defects. Tracheal intubation could be accomplished with intravenous sedation by an experienced anaesthesiologist. Dental occlusion and wiring necessiated the placement of nasotracheal tube for 48-72 hours after surgery.KEY WORDS: Trauma, Maxillofacial injury, Trauma anesthesia, Anaesthesia and critical care 相似文献
33.
One hundred patients undergoing abdominal surgery were included in this prospective study. The role of local application of Betadine, use of synthetic sutures, and use of low pressure subcutaneous suction drainage were evaluated in preventing post-operative wound infection. The infection rate was 15 per cent with Betadine, 15.4 per cent with prolene, 20 per cent with subcutaneous suction drainage and 30.8 per cent in the control group.KEY WORDS: Surgical wound infection, Betadine, Sutures, Infection control 相似文献
34.
Ten monomeric indole alkaloids have been identified from the roots of KOPSIA OFFICINALIS. Four of them are known: (-)-kopsinine 1, (+)-5,22-dioxokopsane 2, (-)-tetrahydroalstonine 4, and (-)-quebrachamine 3; and six are new: (-)-isoeburnamine 5 (enantiomer of the known alkaloid (+)-isoeburnamine), (-)-N-methoxycarbonyl-12-methoxykopsinaline 7, (-)-N-methoxycarbonyl-11,12-methylenedioxy kopsinaline 8, (-)-N-methoxycarbonyl-11,12-dimethoxykopsinaline 9, (-)-11,12-methylenedioxykopsinaline 10, and (-)-12-methoxykopsinaline 11. 相似文献
35.
Lee SH Huang JW Hung KY Leu LJ Kan YT Yang CS Chung Wu D Huang CL Chen PY Chen JS Chen WY 《Artificial organs》2000,24(11):841-844
A multicenter collaborative study was performed to investigate the prevalence of abnormal blood contents of 6 trace metals, copper (Cu), zinc (Zn), aluminum (Al), lead (Pb), cadmium (Cd), and mercury (Hg), in hemodialysis (HD) patients and to analyze their relationship with the medications, such as CaCO3, Ca acetate, Al containing phosphate-binding agents, 1,25-dihydroxy vitD3, 1-hydroxy vitD3, and erythropoietin (EPO), as well as hematocrit level, by chi-square statistics. From 6 medical centers in Taiwan, we included 456 patients in maintenance HD for more than 4 months for this study, and they had continued the previously mentioned medications for at least 3 months. Blood samples were collected before initiating HD, and atomic absorption spectrophotometry was used to measure plasma levels of Cu, Zn, and Al as well as whole blood levels of Pb, Cd, and Hg. Three hundred seventy-five (78%) of the HD patients had low plasma Zn levels, that is, <800 microg/L, and the mean (+/-SD) concentration was 705.8 (+/-128.23) microg/L in all subjects. One hundred forty-one (31%) of the HD patients had high plasma Al, that is, >50 microg/L, and the mean (+/-SD) was 44.30 (+/-28.28) microg/L in all subjects. Three hundred thirty-three (73%) of the dialysis patients had high Cd levels, that is, >2.5 microg/L, and the mean (+/-SD) was 3.32 (+/-1.49) microg/L in all subjects. The majority of HD patients had normal blood levels of Cu, PB, and Hg. Only 21 (4. 6%), 5 (1.1%), and 3 (0.06%) patients had elevated blood levels of Cu, Pb, and Hg, respectively. Their mean (+/-SD) blood concentration of Cu, Pb, and Hg were 1,049.78 (+/-233.25) microg/L, 7.45 (+/-3.95) microg/dL, and 3.17 (+/-25.56) microg/L, respectively. Three patients had elevated plasma Hg concentrations, that is, 546, 12.6, and 24.0 microg/L, respectively. In the 152 normal healthy age and sex matched control group, the blood levels of Al, Cd, and Pb were all significantly lower than the HD patients. However, the levels of Cu and Zn were higher in the control group. The Hg level was not significantly different in both groups. There was no statistical difference between patients with normal and abnormal blood levels of trace metals in various medications except Al containing phosphate binder. The Al containing phosphate binder users had significantly higher plasma Al levels (54.71 +/- 26.70 versus 41.15 +/- 28.03 microg/L, p < 0.001) and hematocrit levels (29.61 +/- 4.61 versus 27. 81 +/- 3.91, p < 0.0005). There was no statistical correlation between erythropoietin (EPO) dose and hematocrit level in these patients. In conclusion, the blood level of trace metals of these HD patients except Al was not related to their medications. However, caution must be exercised in interpreting this result as dose and duration of medication; efficiency of HD and water treatment may play an important role. Otherwise, environmental factors, diet, and the aging process may contribute to the trace metal burden in uremia. Thus, Zn and Cu are abundant in seafood, and Cd is abundant in contaminated plants such as rice. 相似文献
36.
Toru Sugiyama Takashi Nishida Akio Kataoka Kan Komai Naofumi Ookura Toshio Oobuchi Michiaki Yakushiji 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(2):92-96
Background We investigated retrospectively the records and tissue samples of patients with primary ovarian transitional cell carcinoma
to determine clinical and pathologic features.
Methods The records of 3 patients with ovarian transitional cell carcinoma were reviewed using data from several imaging techniques:
transvaginal ultrasound, computed tomography, and magnetic resonance imaging. We also determined levels of several tumor marker
molecules; and the level of carbohydrate antigen 125 (CA 125), was examined by means of immunohistochemistry.
Results The tumors of 2 patients were classified as pure trnasitional cell carcinoma; in the remaining patient, as predominantly transitional
cell carcinoma. All tumors were bilateral, and 2 of the 3 tumors formed solid masses. Areas of irregular high intensity signals
were seen in magnetic resonance images of the solid parts of the tumors. All 3 tumors tested positive for CA 125; histochemical
expression was confined to the tumor cell membrane and/or the cytoplasm in all cases. The tumors of all 3 patients tested
negative for carcinoembryonic antigen (CEA), and second-look laparotomies did not reveal any residual neoplasms in any of
the patients. The patients have been in a disease-free state for 34, 42, and 14 months, respectively.
Conclusion Our results suggest that transitional cell carcinomas tend to arise bilaterally and to form solid tumors. Magnetic resonance
imaging was a useful diagnostic modality in these cases. Transitional cell carcinoma was characterized by the presence of
CA 125 and the absence of CEA. 相似文献
37.
Serving personnel of Armed Forces admitted with tuberculosis between Apr 1996–1999 were evaluated for co-infection of tuberculosis and HIV. Sixty (1.06%) of tuberculosis patients were found to be HIV positive. Initial test was done by spot kits and subsequently confirmed by ELISA on two different samples. Majority of the cases were in sexually active age group 48 (80%). Alcohol and smoking was associated in 80% cases. Thirty six (60%) were sputum smear positive for AFB. Twenty eight (46.7%) gave history of exposure to sex workers. Family members were not available for study. Sero prevalence of HIV in association with tuberculosis is less in Armed Forces compared to civil population.KEY WORDS: HIV, Seroprevalence, Tuberculosis 相似文献
38.
Obstetric outcome in 232 ovum donation pregnancies 总被引:3,自引:0,他引:3
Hossam I. Abdalla Consultant Anne Billett Clinical Research Fellow rew K. S. Kan Clinical Research Fellow Sabah Baig Clinical Research Fellow Marie Wren Infertility Specialist Lena Korea Ovum Donation Co-ordinator John W. W. Studd Consultant 《BJOG : an international journal of obstetrics and gynaecology》1998,105(3):332-337
39.
Sascha Fauser Hubert Kalbacher Nils Alteheld Kan Koizumi Tim U. Krohne Antonia M. Joussen 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2004,242(7):582-586
Background The anti-inflammatory drug etanercept may be an effective therapeutic agent in diabetic retinopathy. In order to further evaluate its potential, the pharmacokinetics and safety of this drug after intravitreal delivery were investigated.Methods After intravitreal administration of etanercept in rabbits, clinical examination, electroretinography (ERG), visually evoked potentials (VEP) and histology were evaluated. The pharmacokinetics and distribution of etanercept were analyzed using fluorescence-coupled protein at 0, 2, 4, and 8 weeks after injection in vitreous, retina, and choroid.Results No adverse effects and signs of toxicity were found. Etanercept showed peak concentrations after 4 weeks in the retina and choroid.Conclusions Intravitreally delivered etanercept is safe and results in high concentrations in the retina and choroid over a long period of time. 相似文献
40.
DANIEL KK NG POK-YU CHOW WAI-PING LAI KIT-CHING CHAN BO-LING TSANG AND HANG-YIN SO 《Pediatrics international》2006,48(2):158-162
BACKGROUND: The aim of this study was to compare the effectiveness of an intensive asthma education program (group B) with that of a standard asthma education program (group A). METHODS: A prospective randomized single blinded study was conducted in the pediatric department of a public hospital in Hong Kong. Children aged 2-15 years admitted to the pediatric department with an acute attack of asthma were recruited. A standard asthma education program (group A) or an intensive asthma education program (group B) for children were offered. The main outcome measures include the number of visits to the emergency department and the number of hospitalization for asthma during the 3 month follow-up period. RESULTS: A total of 45 children were in group A and 55 in group B. Group B had statistically significant reductions in the number of visits to the emergency department and the number of hospitalizations. Drug compliance was also significantly improved in group B. Parents' satisfaction rate was also higher in group B. CONCLUSION: The intensive asthma education program might be more cost effective than the standard asthma education program in the management of asthmatic children admitted to hospital in Hong Kong. 相似文献