全文获取类型
收费全文 | 1960篇 |
免费 | 150篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 77篇 |
妇产科学 | 74篇 |
基础医学 | 260篇 |
口腔科学 | 44篇 |
临床医学 | 111篇 |
内科学 | 458篇 |
皮肤病学 | 17篇 |
神经病学 | 174篇 |
特种医学 | 71篇 |
外科学 | 288篇 |
综合类 | 48篇 |
一般理论 | 1篇 |
预防医学 | 87篇 |
眼科学 | 41篇 |
药学 | 185篇 |
中国医学 | 6篇 |
肿瘤学 | 156篇 |
出版年
2023年 | 23篇 |
2022年 | 35篇 |
2021年 | 84篇 |
2020年 | 27篇 |
2019年 | 48篇 |
2018年 | 58篇 |
2017年 | 45篇 |
2016年 | 70篇 |
2015年 | 61篇 |
2014年 | 76篇 |
2013年 | 101篇 |
2012年 | 148篇 |
2011年 | 136篇 |
2010年 | 72篇 |
2009年 | 72篇 |
2008年 | 115篇 |
2007年 | 137篇 |
2006年 | 95篇 |
2005年 | 91篇 |
2004年 | 93篇 |
2003年 | 71篇 |
2002年 | 60篇 |
2001年 | 35篇 |
2000年 | 36篇 |
1999年 | 30篇 |
1998年 | 21篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 13篇 |
1994年 | 8篇 |
1992年 | 8篇 |
1991年 | 23篇 |
1990年 | 12篇 |
1989年 | 13篇 |
1988年 | 9篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 13篇 |
1984年 | 18篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1975年 | 5篇 |
1974年 | 8篇 |
1973年 | 11篇 |
1972年 | 6篇 |
1971年 | 6篇 |
1970年 | 6篇 |
1965年 | 4篇 |
排序方式: 共有2116条查询结果,搜索用时 31 毫秒
41.
Rishabh Kumar Prachi Kala Geeta S. Narayanan Bhaskar Vishwanathan Sowmya Narayanan Sanjeet Mandal Arpitha Rao Gangadharappa Gowda 《Brachytherapy》2021,20(1):112-117
PURPOSEImage-guided adaptive brachytherapy (IGABT) recently has shown excellent clinical outcomes with superior local control and less toxicity. For IGABT, T2W (T2-weighted) MRI is the gold standard. However, studies have shown that target delineation with the same results in uncertainties, poor interobserver variabilities, and low conformity indices for high-risk clinical target volume contours. In this study, we investigate the role of diffusion-weighted imaging–derived apparent diffusion coefficient (ADC) maps to aid in IGABT. We also evaluated ADC from the baseline to brachytherapy.Methods and MaterialsThirty selected patients were enrolled for this study, and two MRIs were taken at diagnosis and before brachytherapy. Patients were divided into two groups, Group 1 being patients with parametrial involvement before external beam radiotherapy and no parametrial involvement before brachytherapy. Group 2 included patients with parametrial involvement before external beam radiotherapy and persistent parametrial involvement before brachytherapy. ADC was measured at the center, edge, and 1 cm from the edge.ResultsThe measured ADC increased from diagnosis to brachytherapy, and this increase was more for the patients in Group 1 than in Group 2. The mean TDadc (diagnosis ADC, center), TEadc (tumor edge ADC diagnosis), and T1cmDadc (1 cm from edge at diagnosis) were 0.884, 1.45, and 1.9 × 10?3 mm2/s, respectively. The TBadc (ADC at brachytherapy, center), TEBadc (tumor edge ADC at brachytherapy), and TE1cmBadc (1 cm from edge brachytherapy) were 1.2, 1.8, and 2.3 × 10?3 mm2/s, respectively, p-value <0.00001. No abnormal ADC was present outside the high-risk clinical target volume contours.ConclusionMRI-based IGABT using T2W imaging essentially covers all functionally abnormal zones at brachytherapy. Diffusion-weighted imaging, along with ADC maps, should only be used as a supplement for target delineation. 相似文献
42.
Koda Samantha A. Subramaniam Kuttichantran Pouder Deborah B. Yanong Roy P. Frasca Salvatore Popov Vsevolod L. Waltzek Thomas B. 《Virus genes》2021,57(5):448-452
Virus Genes - The genus Megalocytivirus includes viruses known to cause significant disease in aquacultured fish stocks. Herein, we report the complete genome sequences of two megalocytiviruses... 相似文献
43.
Subramaniam Puvaneswary Hanumantha Rao Balaji Raghavendran Nurul Syuhada Ibrahim Malliga Raman Murali Azhar Mahmood Merican T. Kamarul 《International journal of medical sciences》2013,10(12):1608-1614
The objective of this study was to compare the morphological and chemical composition of bone graft (BG) and coral graft (CG) as well as their osteogenic differentiation potential using rabbit mesenchymal stem cells (rMSCs) in vitro. SEM analysis of BG and CG revealed that the pores in these grafts were interconnected, and their micro-CT confirmed pore sizes in the range of 107-315 µm and 103-514 µm with a total porosity of 92% and 94%, respectively. EDS analysis indicated that the level of calcium in CG was relatively higher than that in BG. FTIR of BG and CG confirmed the presence of functional groups corresponding to carbonyl, aromatic, alkyl, and alkane groups. XRD results revealed that the phase content of the inorganic layer comprised highly crystalline form of calcium carbonate and carbon. Atomic force microscopy analysis showed CG had better surface roughness compared to BG. In addition, significantly higher levels of osteogenic differentiation markers, namely, alkaline phosphatase (ALP), Osteocalcin (OC) levels, and Osteonectin and Runx2, Integrin gene expression were detected in the CG cultures, when compared with those in the BG cultures. In conclusion, our results demonstrate that the osteogenic differentiation of rMSCs is relatively superior in coral graft than in bone graft culture system. 相似文献
44.
Catharina M. L. Zegers Wouter van Elmpt Katrin Szardenings Hartmuth Kolb Alan Waxman Rathan M. Subramaniam Dae Hyuk Moon Jacqueline C. Brunetti Shyam M. Srinivas Philippe Lambin David Chien 《European journal of nuclear medicine and molecular imaging》2015,42(12):1840-1849
Purpose
Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [18F]HX4 in patients with head and neck and lung cancer.Methods
Nine patients with lung cancer and ten with head and neck cancer were included in the analysis (NCT01075399). Two sequential pretreatment [18F]HX4 PET/CT scans were acquired within 1 week. The maximal and mean standardized uptake values (SUVmax and SUVmean) were defined and the tumor-to-background ratios (TBR) were calculated. In addition, hypoxic volumes were determined as the volume of the tumor with a TBR >1.2 (HV1.2). Bland Altman analysis of the uptake parameters was performed and coefficients of repeatability were calculated. To evaluate the spatial repeatability of the uptake, the PET/CT images were registered and a voxel-wise comparison of the uptake was performed, providing a correlation coefficient.Results
All parameters of [18F]HX4 uptake were significantly correlated between scans: SUVmax (r?=?0.958, p?<?0.001), SUVmean (r?=?0.946, p?<?0.001), TBRmax (r?=?0.962, p?<?0.001) and HV1.2 (r?=?0.995, p?<?0.001). The relative coefficients of repeatability were 15 % (SUVmean), 17 % (SUVmax) and 17 % (TBRmax). Voxel-wise analysis of the spatial uptake pattern within the tumors provided an average correlation of 0.65?±?0.14.Conclusion
Repeated hypoxia PET scans with [18F]HX4 provide reproducible and spatially stable results in patients with head and neck cancer and patients with lung cancer. [18F]HX4 PET imaging can be used to assess the hypoxic status of tumors and has the potential to aid hypoxia-targeted treatments.45.
Junguk Hur Jacqueline R. Dauch Lucy M. Hinder John M. Hayes Carey Backus Subramaniam Pennathur Matthias Kretzler Frank C. Brosius III Eva L. Feldman 《Diabetes》2015,64(9):3294-3304
To define the components of the metabolic syndrome that contribute to diabetic polyneuropathy (DPN) in type 2 diabetes mellitus (T2DM), we treated the BKS db/db mouse, an established murine model of T2DM and the metabolic syndrome, with the thiazolidinedione class drug pioglitazone. Pioglitazone treatment of BKS db/db mice produced a significant weight gain, restored glycemic control, and normalized measures of serum oxidative stress and triglycerides but had no effect on LDLs or total cholesterol. Moreover, although pioglitazone treatment normalized renal function, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic nerve conduction velocities, but significantly improved measures of small unmyelinated nerve fiber architecture and function. Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis, adipokine signaling, and lipoprotein signaling, which likely contributed to the blunted therapeutic response. Similar analyses of dorsal root ganglion neurons revealed a salutary effect of pioglitazone on pathways related to defense and cytokine production. These data suggest differential susceptibility of small and large nerve fibers to specific metabolic impairments associated with T2DM and provide the basis for discussion of new treatment paradigms for individuals with T2DM and DPN. 相似文献
46.
Amit Kumar Sharma Neeraj Gupta Dilip Kumar Kala Tarun Patni Ramakant Dixit Satyadeep Verma Arjun Chandran 《The Indian journal of tuberculosis》2018,65(3):233-236
Aims and objectives
To determine the prevalence and pattern of resistance to second line drugs among multi drug resistant (MDR) tuberculosis patients being treated on category IV regimen.Methodology
This study was conducted at Department of Respiratory Medicine, J.L.N. Medical College, Ajmer in collaboration with IRL, STDC, Ajmer. Second line anti tubercular drug sensitivity for 398 multi drug resistant tuberculosis patients (between June-2015 and June-2016) was done to find out prevalence and pattern of resistance to second line drugs. Second line drug sensitivity was performed at accredited laboratory, Microbiology department, S.M.S. Medical College, Jaipur.Results
Among these 398 patients, 136 (34.17%) were resistant to fluoroquinolones (Ofloxacin) (Pre XDR); 18 (4.52%) were resistant to one of the aminoglycosides (Inj. Kanamycin, Capreomycin, Amikacin) (Pre XDR); while 22 (5.53%) patients were resistant to fluoroquinolones as well as aminoglycosides (XDR). 148 (37.18%) patients were found sensitive to both the drugs. Samples of 41 (10.3%) patients were contaminated and no growth was seen in 33 (8.29%) patients.Conclusion
Nearly half of the multi drug resistant (MDR) tuberculosis patients (44.22%) being treated on category IV regimen also have resistance to either fluoroquinolones or aminoglycosides or both i.e. Pre XDR or XDR. This may result in poor outcome of category IV regimen under RNTCP. There is a strong need for provision of culture sensitivity for all first line drugs and at least two second line drugs viz. Fluoroquinolones and aminoglycosides for all the patients registered as smear positive under RNTCP. There is also a need for development of rapid culture technique for sensitivity to second line drugs. 相似文献47.
48.
49.
Renal denervation (RDN) is a new perspective method for the treatment of resistant hypertension. Surgical sympathectomy has been considered as a possible treatment of hypertension for many years—long before the discovery of antihypertensive drugs. The selective percutaneous transcatheter application of radiofrequency energy in renal arteries to eliminate sympathetic nerve fibers has been used in human medicine since 2009. The recent boom of this method has been supported by published clinical studies showing efficacy of this new treatment modality. Nevertheless, RDN is still an experimental method to be used only in specialized research centers. In this review we will provide up-to-date information about the use of RND as a novel method for the treatment of hypertension as well as discuss potential perspectives of RND in the treatment of various medical conditions. 相似文献