全文获取类型
收费全文 | 56332篇 |
免费 | 3123篇 |
国内免费 | 606篇 |
专业分类
耳鼻咽喉 | 986篇 |
儿科学 | 646篇 |
妇产科学 | 826篇 |
基础医学 | 9772篇 |
口腔科学 | 1354篇 |
临床医学 | 4905篇 |
内科学 | 10574篇 |
皮肤病学 | 1874篇 |
神经病学 | 3989篇 |
特种医学 | 3023篇 |
外科学 | 7489篇 |
综合类 | 220篇 |
现状与发展 | 1篇 |
一般理论 | 17篇 |
预防医学 | 2715篇 |
眼科学 | 1234篇 |
药学 | 4992篇 |
中国医学 | 625篇 |
肿瘤学 | 4819篇 |
出版年
2023年 | 428篇 |
2022年 | 1327篇 |
2021年 | 2058篇 |
2020年 | 988篇 |
2019年 | 1292篇 |
2018年 | 1671篇 |
2017年 | 1245篇 |
2016年 | 1760篇 |
2015年 | 2567篇 |
2014年 | 3063篇 |
2013年 | 3495篇 |
2012年 | 5315篇 |
2011年 | 4807篇 |
2010年 | 2812篇 |
2009年 | 2374篇 |
2008年 | 3417篇 |
2007年 | 3104篇 |
2006年 | 2658篇 |
2005年 | 2357篇 |
2004年 | 2023篇 |
2003年 | 1695篇 |
2002年 | 1438篇 |
2001年 | 1367篇 |
2000年 | 1262篇 |
1999年 | 910篇 |
1998年 | 376篇 |
1997年 | 264篇 |
1996年 | 217篇 |
1995年 | 182篇 |
1994年 | 157篇 |
1993年 | 139篇 |
1992年 | 334篇 |
1991年 | 317篇 |
1990年 | 283篇 |
1989年 | 260篇 |
1988年 | 253篇 |
1987年 | 252篇 |
1986年 | 182篇 |
1985年 | 170篇 |
1984年 | 120篇 |
1983年 | 112篇 |
1982年 | 56篇 |
1981年 | 60篇 |
1979年 | 81篇 |
1978年 | 69篇 |
1975年 | 52篇 |
1974年 | 60篇 |
1973年 | 51篇 |
1972年 | 50篇 |
1970年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Atul K Madan Constantine T Frantzides Christopher L Tebbit William C Park Nakka V Aruna Kumari Nina Shervin 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2004,8(2):191-193
BACKGROUND: Laparoscopic suturing and tying constitute advanced minimally invasive surgery skills. Developing proficiency in the standard methods with needle drivers is often an arduous process. Recent advances in laparoscopic instrumentations has allowed for easier methods of suturing and tying. This study investigated the hypothesis that the use of a specialized suturing device and a specialized tying device allows inexperienced medical students to suture and tie laparoscopically. METHODS: Preclinical medical students who had not received any training in open or laparoscopic surgery were included in this investigation. Each student was given a 5-minute demonstration of a specialized suturing device and a specialized tying device. The medical students were not allowed to deploy either device before actual use. After the demonstration, each student was given the device to use in a porcine model. Times were recorded and a subjective grade was given for each student. RESULTS: Twenty medical students were involved in this study. All medical students were able to complete the task of suturing and tying. The average time to suture was 104.6 seconds and the average time to tying was 31.2 seconds. The average subjective performance grade was 90 (out of 100). CONCLUSION: Specialized devices are easy to learn and use for laparoscopic suturing and tying with minimal instruction even for inexperienced medical students. Even surgeons who are not well versed in laparoscopic surgery should be able to suture and tie with certain laparoscopic instruments. 相似文献
32.
33.
The authors describe a case of idiopathic hypereosinophilic syndrome (HES) terminated as a T-cell lymphoma in a 3-year-old girl. The clinical course was chronic and characterized by chronic eczema, persistent peripheral blood eosinophilia, organomegaly, interstitial lung change, and pericarditis. Postmortem examination demonstrated a disseminated T-cell lymphoma involving the inguinal lymph node, liver, lung, and kidney. The findings of the current case suggest a possibility that certain abnormalities in this case of idiopathic HES per se may have triggered the development of malignant lymphoma, and it may represent a transition of idiopathic HES into a T-cell lymphoma. Other possible sequences are discussed. The development of T-cell malignancy in idiopathic HES in a girl is quite an unusual presentation. 相似文献
34.
35.
36.
Su Jin Park Su Jin Kim Yumie Rhee Ji Hyun Byun Seong Hwan Kim Myoung Hee Kim Eun Jig Lee Sung-Kil Lim 《Journal of bone and mineral research》2007,22(6):889-896
The FIGNL1 gene was proven to be a new subfamily member of ATPases associated with diverse cellular activities (AAA proteins). In this in vitro study, the AAA proteins inhibited osteoblast proliferation and stimulated osteoblast differentiation. We showed that FIGNL1 may play some regulatory role in osteoblastogenesis. INTRODUCTION: The fidgetin-like 1 (FIGNL1) gene encodes a new subfamily member of ATPases associated with diverse cellular activities (AAA proteins). Although the FIGNL1 protein localizes to both the nucleus and cytoplasm, the function of FIGNL1 remains unknown. In a previous study, we identified several genes that mediate the anabolic effects of basic fibroblast growth factor (bFGF) on bone by using microarray data. FIGNL1 was one of the genes that downregulated >2-fold in MC3T3-E1 cells after treatment with bFGF. Therefore, this study was aimed to identify and confirm the function of FIGNL1 on osteoblastogenesis. MATERIALS AND METHODS: We examined the effect of the FIGNL1 gene on proliferation, differentiation, and apoptosis in mouse osteoblast cells (MC3T3-E1 and mouse primary calvarial cells) using flow cytometry, RT-PCR, cell proliferation assay, and cell death assay. MC3T3-E1 cells and mouse calvarial cells were transfected with small interfering RNA (siRNA) directed against the FIGNL1 or nontargeting control siRNA and examined by cell proliferation and cell death assays. Also, FIGNL1 was fused to enhance green fluorescent protein (EGFP), and the EGFP-fused protein was transiently expressed in MC3T3-E1 cells. RESULTS: Reduced expression of FIGNL1 by bFGF and TGF-beta1 treatment was verified by RT-PCR analysis. Overexpression of FIGNL1 reduced the proliferation of MC3T3-E1 and calvarial cells, more than the mock transfected control cells did. In contrast, siFIGNL1 transfection significantly increased the proliferation of osteoblasts, whereas overexpression of FIGNL1 did not seem to alter apoptosis in osteoblasts. Meanwhile, overexpression of FIGNL1 enhanced the mRNA expression of alkaline phosphatase (ALP) and osteocalcin (OCN) in osteoblasts. In contrast, siFIGNL1 decreased the expression of ALP and OCN. A pEGFP-FIGNL1 transfected into MCT3-E1 cells had an initially ubiquitous distribution and rapidly translocated to the nucleus 1 h after bFGF treatment. CONCLUSIONS: From these results, we proposed that FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation. Further analyses of FIGNL1 will be needed to better delineate the mechanisms contributing to the inhibition of proliferation and stimulation of osteoblast differentiation. 相似文献
37.
38.
Seong-Beom Koh Byung-Jo Kim Moon Ho Park Sung-Wook Yu Kun-Woo Park Dae Hie Lee 《Journal of clinical neuroscience》2007,14(11):1073-1077
Cerebral infarction as a complication of tubercular (TB) meningitis is not uncommon, but an adequate comparison of patients with and without stroke has not been carried out. This study was performed to evaluate the clinical characteristics of cerebral infarction secondary to TB meningitis, and to investigate predictive factors for cerebral infarction in patients with TB meningitis. Patients with TB meningitis were recruited over a period of 56 months. They were divided into two groups, those with and those without stroke. Demographic features and clinical, laboratory, and neuroradiological findings were compared between the two groups. We classified strokes into subtypes using neuroimaging findings. Of the 38 patients who were diagnosed with TB meningitis, eight also experienced cerebral infarction. The percentage of cerebrospinal fluid leukocytes that were neutrophils was significantly higher in patients with stroke (68%) than in patients without stroke (31%; p=0.0001). Upon initial CT imaging, meningeal enhancement was found in 11 patients, and of these patients, six experienced stroke. There were no significant differences between the groups with respect to other clinical and laboratory features, including demographic features, time between meningitis onset and treatment initiation, peripheral white blood cell count, and cerebrospinal fluid findings. Five of the eight patients who developed stroke had lacunar infarcts. One of the three patients with territorial nonlacunar infarction died due to herniation. When treating patients with TB meningitis, the possibility of cerebral infarction should be considered when patients develop focal neurological signs, meningeal enhancement on a CT scan, and sustained polymorphic cerebrospinal fluid pleocytosis. 相似文献
39.
40.