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991.
Kudo Y Minegishi M Saito N Itoh T Fushimi J Takahashi H Suzuki A Narita A Sato Y Miura J Yoshihara K Meguro K Imaizumi M Sato M Murakawa Y Tsuchiya S 《The Tohoku journal of experimental medicine》2003,199(2):111-118
Retrospective analysis was conducted in 51 autologous peripheral blood progenitor cell (PBPC) collections using the Spectra AutoPBSC System from patients with hematologic malignancies and solid tumors to study the predictive value of CD34+ cell counts in the peripheral blood for the yield of CD34+ cells in the apheresis product. The correlation coefficients for CD34+ cells microL(-1) of peripheral blood with CD34+ cell yield (x 10(6) kg(-1) of body weight and x 10(5) kg(-1) of body weight L(-1) of blood processed) were 0.903 and 0.778 (n=51 collections), respectively. Products collected from patients with CD34+ cell counts below 15 microL(-1) in the peripheral blood contained a median of 0.49 x 10(6) CD34+ cells kg(-1) (range: 0.05-2.55), whereas those with CD34+ cell counts more than 15 microL(-1) contained a median of 3.72 x 10(6) CD34+ cells kg(-1) (range: 1.06-37.57). From these results, a number of at least 15 CD34+ cells microL(-1) in the peripheral blood ensured a minimum yield of 1 x 10(6) CD34+ cells kg(-1) as obtained by a single apheresis procedure. The number of CD34+ cells in the peripheral blood can be used as a good predictor for timing of apheresis and estimating PBPC yield. With regard to our results, apheresis with a possibly poor efficiency should be avoided because the collection procedure is time-consuming and expensive. 相似文献
992.
Dose‐finding and efficacy confirmation trial of the superselective intra‐arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212): Dose‐finding phase 下载免费PDF全文
Akihiro Homma MD PhD Rikiya Onimaru MD PhD Kazuto Matsuura MD PhD Hirotaka Shinomiya MD PhD Tomohiro Sakashita MD PhD Kiyoto Shiga MD PhD Hiroyuki Tachibana MD Kenichi Nakamura MD PhD Junki Mizusawa ME Hideaki Kitahara MD Junko Eba MD Haruhiko Fukuda MD Masato Fujii MD PhD Ryuichi Hayashi MD 《Head & neck》2018,40(3):475-484
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Masao Yoshinaga Masami Nagashima Toshimitsu Shibata Ichiro Niimura Mitsuo Kitada Toshiaki Yasuda Mari Iwamoto Junko Kamimura Mayu Iino Hitoshi Horigome Masashi Seguchi Sumi Aiba Naomi Izumida Takashi Kimura Hiroya Ushinohama Junichiro Nishi Yukiharu Kono Yuichi Nomura Koichiro Miyata 《Circulation journal》2003,67(12):1007-1012
The objective of this study was to determine who is at risk for cardiac events among young patients with long QT syndrome (LQTS) with or without a past history of LQTS-related cardiac events. The subjects were young patients with LQTS who had visited one of 36 hospitals from January 1997 to August 2000 in Japan. To predict the risk factors for cardiac events, stepwise regression analyses were performed for a total of 197 cases. There were 7 of 129 cases (5%) without a past history and 32 of the 68 (47%) cases with a past history of LQTS-related cardiac events that experienced new events after diagnosis (p<0.0001). Patients with a family history showed a higher incidence of symptoms both before and after diagnosis than patients with sporadic occurrence. Analyses revealed that noncompliance with medication and a lower age at diagnosis were significant predictors for the group with a past history. A negative predictive value <4 points was 100% in the group without a past history. To prevent future cardiac events, compliance with medication must be improved in those with a past history. A total LQTS score <4 points was useful to predict the absence of cardiac events in the group without a past history. 相似文献
997.
Junko Nagura Yoshio Nakagawa Minoru Miyanaga Kenji Matsuoka Kyohei Hayashi Kotaro Ozasa Yoshiyuki Watanabe 《Circulation journal》2004,68(11):982-987
BACKGROUND: The relationship between abdominal visceral fat accumulation and lacunar infarcts has not been previously investigated in Japanese men. METHODS AND RESULTS: The subjects were 637 middle-aged (40-64 years) and 222 elderly (65-79 years) men who participated in a health checkup program from 1999 to 2003. The association between lacunar infarcts identified by magnetic resonance imaging and cardiovascular risk factors, including abdominal visceral fat accumulation evaluated by computed tomography, was examined. The prevalence of lacunar infarcts was 4.9%. Hypertension was associated with lacunar infarcts among both the middle-aged men [age-adjusted odds ratio (OR)=2.9 (95% confidence interval (CI): 1.1-7.8)] and the elderly men [OR=5.1 (95%CI: 1.4-19.0)]. Abdominal visceral fat accumulation was slightly associated with lacunar infarcts among middle-aged men, but not among elderly men: OR in the highest (>or=117 cm(2)) vs lowest (or=143 cm(2)) was still slightly associated with lacunar infarcts after adjustment for age, hypertension, drinking and smoking among middle-aged men [OR=2.7 (95%CI: 0.8-9.1)]. CONCLUSIONS: This cross-sectional study suggests that abdominal visceral fat accumulation is a possible risk factor of lacunar infarcts, in addition to hypertension, in middle-aged Japanese men. 相似文献
998.
Takehiro Karaho Tetsuya Satoh Junko Nakajima Takeshi Nakayama Naoyuki Kohno 《Acta oto-laryngologica》2015,135(2):187-192
Conclusions: Mano-videoendoscopy (MVE), a manometry technique with endoscopic confirmation of the pressure catheter, can supplement the information on upper esophageal sphincter (UES) function, and overcomes the drawbacks of videoendoscopic swallowing study (VESS). Objectives: This study aimed to investigate the possibility of replacing videofluorographic swallowing study (VFSS) with MVE, as a test to precisely evaluate UES function. Methods: Data from 52 patients with dysphagia were retrospectively reviewed. All patients underwent both MVE and VFSS for evaluation of dysphagia. The manometry was performed with a transnasally inserted catheter (2.6 mm outer diameter and four pressure sensors) under endoscopic observation. The sensors were kept at the tongue base, upper pyriform sinus, apex of pyriform sinus, and UES. We statistically compared the manometric parameters of UES relaxation with fluorographic UES opening. Results: Fluorographic UES opening was diagnosed as good in 34 patients and poor in 18 patients. The nadir pressure, pressure drop, and pressure rise in the UES had significant correlation on the fluorographic UES opening. Stepwise logistic regression test revealed that pressure drop, the gap between the resting pressure and the nadir of UES pressure, was a robust parameter for predicting fluorographic UES opening, and the cut-off level to anticipate good fluorographic opening was ≥ 33.5 mmHg (specificity, 0.853; sensitivity, 0.759) 相似文献
999.
Validation of Classification Criteria of Macrophage Activation Syndrome in Japanese Patients With Systemic Juvenile Idiopathic Arthritis 下载免费PDF全文
Masaki Shimizu Mao Mizuta Takahiro Yasumi Naomi Iwata Yuka Okura Noriko Kinjo Hiroaki Umebayashi Tomohiro Kubota Yasuo Nakagishi Kenichi Nishimura Masato Yashiro Junko Yasumura Kazuko Yamazaki Hiroyuki Wakiguchi Nami Okamoto Masaaki Mori 《Arthritis care & research》2018,70(9):1412-1415