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51.
Recessive dystrophic epidermolysis bullosa (RDEB) is an uncommon and severe disorder characterised by trauma-induced blisters, intractable skin ulcers, scarring, milia, and nail dystrophy. We report the good result of both surgical release of fingers allowing spontaneous epithelisation without skin grafting and post-operative meticulous skin care without splinting, followed-up for one year. 相似文献
52.
D. G. Kim C.-Y. Kim S. H. Paek D. S. Lee J.-K. Chung H.-W. Jung B.-K. Cho 《Acta neurochirurgica》1998,140(7):665-674
Summary
Background To determine its roles in the diagnosis and the systemic evaluation of metastatic brain tumours, whole-body positron emission
tomography (PET) using [18F]FDG was performed in 20 consecutive patients.
Methods
All patients were thought to be suffering or needing to be differentiated from metastatic brain tumours. Nine patients had
multiple brain lesions; six were older and showed a rim-enhancing lesion with surrounding oedema; seven had homogeneously
enhancing periventricular lesion(s) on computed tomography (CT) and/or magnetic resonance (MR) imaging, thought to be central
nervous system lymphomas. Two patients had skull mass(es) and two patients had a solid mass suspected to be, respectively,
a haemorrhagic metastasis and a metastatic malignant melanoma. All of them received whole-body [18F]FDG PET and conventional systemic work-up for metastasis in order to compare the results of the two methods.
Results
Metastatic brain tumours were diagnosed on whole-body [18F]FDG PET in eleven patients who had extracranial and intracranial hypermetabolic lesions. In nine of these, a conventional
work-up also detected primary lesions which on whole-body [18F]FDG PET were seen to be hypermetabolic foci. Systemic lymph node metastases were detected by whole-body [18F]FDG PET only in two patients and histological diagnosis was possible by biopsy of lymph nodes rather than of brain lesions.
In the remaining nine patients who had only intracranial hypermetabolic foci, histological diagnosis was made by craniotomy
or stereotactic biopsy. It was confirmed that seven of nine patients were suffering from a primary brain tumour and two from
metastatic carcinoma. None of the nine showed evidence of systemic cancer on conventional work-up. Histological diagnoses
of the primary brain tumours were four cases of primary central nervous system lymphoma and one each of multifocal glioblastoma,
Ewing's sarcoma, and cavernous angioma.
Patients felt no discomfort during the whole-body [18F]FDG PET procedure and there were no complications. The false negative rate in [18F]FDG PET and in conventional work-up was 15.4% and 30.7% respectively. There were no false positives on either [18F]FDG PET or conventional work-up.
Conclusion
It is suggested that whole-body [18F]FDG PET is a safe, reliable, and convenient method for the diagnosis and systemic evaluation of patients thought to be suffering
or needing to be differentiated from a metastatic brain tumour. 相似文献
53.
54.
Zhao Canxi Wu Yan Lei Ying Ruan Heqiu Wolfgang Voelter Albrecht Jung Miriam Schick 《华中科技大学学报(医学英德文版)》1996,16(4):203-204
Zusammenfassung Die Wirkung des ?thylazetatextraktes von Chrysanthemum morifolium auf P. falciparum wurde in vitro untersucht. W?hrend sich
die Parasit?mie bei der Kontrollgruppe bis zu 10. 90 % entwickelte, wurde bei dem mit ?thylazetatextrakt in einer Konzentration
von 100 μg/ml Medium am 5. Tag der Kultur eine signifikante Hemmwirkung auf die Parasiten beobachtet. Die Parasit?mie blieb
bei 1. 00 %.
Diese Arbeit wurde durch die Stiftung von “National Nature Science Foundation of China” finanziert (No. 39260066) 相似文献
55.
Marion Jung EvaMaria Krämer Thomas Müller Horst Antonicek Jacqueline Trotter 《The European journal of neuroscience》1998,10(10):3246-3256
The immortalization of progenitor cells from embryonic murine hippocampus using oncogene‐carrying retroviral vectors is described. Use of a vector encoding the oncogene v‐myc results in lines of nestin‐positive progenitor cells. Limited differentiation ensues if the cells are cultured in the presence of dibutyryl cyclic adenosine monophosphate. In contrast, use of a vector in which the extracellular portion of the epidermal growth factor (EGF) receptor is fused to the neu tyrosine kinase generates lines of pluripotential nestin‐positive progenitor cells, which differentiate upon withdrawal of EGF into neurons and glia. Differentiated neurons expressing action potentials and neurotransmitter receptors make up a high proportion of the cells. These cell lines are useful tools to investigate the characteristics of differentiating neurons and glia, as well as to screen neuroactive drugs. This work has been reported in preliminary form as an abstract (1996 Society for Neuroscience Abstract, #606.20, p. 1537). 相似文献
56.
E G Jung 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1989,40(12):761-762
"Schnyder's rule" states that multiple tumours of the skin are dominantly inherited, whereas solitary tumours of the same histological type are noninherited. This rule may be extended to cover segmental cases representing somatic mutations. 相似文献
57.
To test the hypothesis that complement-mediated cell lysis and cell-mediated cytotoxicity operate by analogous mechanisms, cell membranes from two antibody-dependent cytotoxicity systems were examined by electron microscopy after negative staining. Ring-shaped membrane lesions generally similar to, but larger than, those previously described for complement lysis were observed. These findings are in agreement with recent measurements of larger functional pores for ADCC than complement. 相似文献
58.
Yu-Sheng Chang Pao-Hsien Chu Shih-Ming Jung Kun-Eng Lim Jaw-Ji Chu Chuen Hsueh Ying-Shiung Lee 《Cardiovascular pathology》2005,14(2):104-106
Cardiac papillary fibroelastoma (CPF) is the second most common benign neoplasm of the heart. This study describes the case of an 81-year-old man who was admitted to the hospital for severe vertigo and in whom a tumor at the right ventricular outflow tract (RVOT) was identified incidentally during echocardiography. The CPF was excised smoothly following the confirmation of its position by computed tomography. The comprehensive pathologic findings of CPF were reviewed. Detailed immunohistochemical analyses of CD34 and factor VIII-related antigen were performed on the covering endocardial cells. The unique chondroid metaplasia of fibrous tissue in this CPF has never been reported. This work is the first to present an unusual CPF at the RVOT with reactive process of fibrous connective tissue. 相似文献
59.
Lee J Kim MS Park C Jung EB Choi DH Kim TY Moon SK Park R 《Immunopharmacology and immunotoxicology》2004,26(1):17-28
This study is designed to investigate the effect of morphine on glutamate-induced toxicity of primary rat neonatal astrocytes. Glutamate decreases the intracellular GSH level, and thereby induces cytolysis of astrocytes and C6 glial cells accompanied by apoptotic features. Glutamate-induced cytotoxicity is protected by morphine and antioxidants such as GSH and NAC, whereas MK-801, an antagonist of glutamate receptor NMDA does not protect astrocytes against glutamate toxicity. Also, morphine antagonist, naloxone, as well as selective ligands for opioid receptor subtypes, including DAMGO, DPDPE, and U69593, do not inhibit the protective effect of morphine on glutamate-induced cytotoxicity. Morphine significantly prevents the depletion of GSH by glutamate and thereby inhibits the generation of H2O2 in a dose-dependent manner. Furthermore, morphine prevents the change of mitochondrial permeability transition by glutamate. Taken together, we suggest that morphine protects the primary rat neonatal astrocytes from glutamate toxicity via modulation of intracellular redox status. 相似文献
60.
Peptide motifs of closely related HLA class I molecules encompass substantial differences. 总被引:11,自引:0,他引:11
Olaf Rtzschke Kirsten Falk Stefan Stevanovi Günther Jung Hans-Georg Rammensee 《European journal of immunology》1992,22(9):2453-2456
The peptides presented by major histocompatibility complex class I molecules adhere to strict rules concerning peptide length and occupancy by certain amino acid residues at anchor positions. Peptides presented by HLA-A*0201 molecules, for example, are generally nonapeptides requiring Leu or Met at position 2 and an aliphatic residue, predominantly Val, at position 9. A closely related molecule, HLA-A*0205, differing from the former at four amino acid residues, has a related but substantially different peptide motif. A*0205-presented peptides are still nonapeptides, and position 9 is still aliphatic, although it is preferentially occupied by Leu instead of Val. Position 2 not only allows aliphatic residues but also polar ones. Occupancy at position 6, considered as an auxiliary anchor in A*0201, as well as non-anchor residues at positions 3, 4, and 8 are relatively well conserved between the two peptide motifs. Thus, although a number of the T cell epitopes presented by the two HLA-A2 forms is expected to be identical, a considerable number of epitopes should be different. 相似文献