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951.
952.
953.
Howard B Moss Thomas L Hardie John P Dahl Wade Berrettini Ke Xu 《Neuropsychopharmacology》2007,61(8):974-978
BACKGROUND: Some studies have associated alcohol dependence (AD) with the human serotonin (5-HT)(1B) receptor (HTR1B). This investigation explored the functional responsivity of HTR1B in abstinent AD men using a sumatriptan challenge, while measuring genetic heterogeneity in the HTR1B promoter. METHODS: Abstinent AD men (n = 27) and abstinent men without any alcohol use disorder (n = 19) were administered 6 mg of sumatriptan succinate, subcutaneously. Plasma samples collected over the following 2 hours were assayed for growth hormone (GH) concentrations. His DNA was genotyped for the A-161T and T-261G polymorphisms of the HTR1B promoter and diplotypes determined. RESULTS: Integrated GH responses were predicted by interactions of AD and promoter diplotypes, as well as subject ethnicity. The final model accounted for nearly 35% of the variance in GH responses. Post hoc evaluation revealed that AD was associated with a blunting of GH secretion only among individuals with the most common HTR1B diplotype (TT/TT). CONCLUSIONS: A blunting of GH responses in abstinent AD men was observed only among those with the most common HTR1B promoter diplotype. Less common promoter diplotypes appeared protective. Controlling for genetic background is a useful augmentation of case-control pharmacological challenge strategies designed to elucidate the psychobiology of AD and other complex disorders. 相似文献
954.
Joseph C Whitt Charles L Dunlap John L Sheets Michael L Thompson 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(3):368-376
The term keratoameloblastoma has been used to describe a histologically heterogeneous group of ameloblastoma variants which have in common the formation of keratin by the ameloblastomatous epithelium. The English language literature contains reports of only 12 cases of keratoameloblastoma, of which 4 cases exhibited a papilliferous component. We report a unique tumor that we believe falls within the broad histopathologic spectrum of keratoameloblastoma. We review the key clinical and histopathologic features of the previously reported cases of keratoameloblastoma and present an additional case that presented as an expansile, radiolucent lesion with internal opacification between the roots of teeth in the left anterior maxillary alveolar ridge of a 45-year-old white male. There is wide variation in the histopathologic appearance of cases reported under the appellation keratoameloblastoma. Our case exhibited a histopathologic feature shared by only 2 of the previously reported cases, notably islands and anastomosing cords of epithelium forming lamellated, pacinian-like stacks of parakeratin that extruded into the collagenous tumor stroma without eliciting a foreign body response. Due to the small number of reported cases, we are unable to accurately assess whether the biologic behavior of keratoameloblastoma differs from other histologic types of ameloblastoma. 相似文献
955.
956.
Richard A. Perugini Steven H. Quarfordt Stephen Baker Donald R. Czerniach Demetrius E. M. Litwin John J. Kelly 《Journal of gastrointestinal surgery》2007,11(9):1083-1090
Introduction Obese individuals may have normal insulin–glucose homeostasis, insulin resistance, or diabetes mellitus. Whereas gastric bypass
cures insulin resistance and diabetes mellitus, its effects on normal physiology have not been described. We studied insulin
resistance and β-cell function for patients undergoing gastric bypass.
Methods One hundred thirty-eight patients undergoing gastric bypass had fasting insulin and glucose levels drawn on days 0, 12, 40,
180, and 365. Thirty-one (22%) patients with diabetes mellitus were excluded from this analysis. Homeostatic model of assessment
was used to estimate insulin resistance, insulin sensitivity, and β-cell function. Based on this model, patients were categorized
as high insulin resistance if their insulin resistance was >2.3.
Results Body mass index did not correlate with insulin resistance. Forty-seven (34%) patients were categorized as high insulin resistance.
Correction of insulin resistance for this group occurred by 12 days postoperatively. Sixty (43%) patients were categorized
as low insulin resistance. They demonstrated an increase of β-cell function by 12 days postoperatively, which returned to
baseline by 6 months. At 1 year postoperatively, the low insulin resistance group had significantly higher β-cell function
per degree of insulin sensitivity.
Conclusions Adipose mass alone cannot explain insulin resistance. Severely obese individuals can be categorized by degree of insulin resistance,
and the effect of gastric bypass depends upon this preoperative physiology. 相似文献
957.
Arthroscopic Assisted Fixation of Juvenile Intra-articular Epiphyseal Ankle Fractures 总被引:1,自引:0,他引:1
Meagan M. Jennings DPM Pieter Lagaay DPM John M. Schuberth DPM 《The Journal of foot and ankle surgery》2007,46(5):376-386
The purpose of this study was to present the long-term follow-up of a case series of arthroscopically assisted fixation of juvenile intraarticular epiphyseal ankle fractures. The functional and radiographic outcomes of 6 patients with a range of follow-up of 1 to 5 years were evaluated. Five of the 6 patients had triplane injuries, whereas the remaining patient sustained a juvenile Tillaux fracture. All of the patients returned to full activity within 14 weeks of surgery, and none of the patients had any restriction in the ankle range of motion at the time of last follow-up. The results of this small series of patients suggest that arthroscopic-assisted, percutaneous fixation of intraarticular juvenile epiphyseal ankle fractures is an effective, less invasive surgical technique. Several surgical maneuvers that are helpful in the consistent execution of this technique are also mentioned. 相似文献
958.
959.
Beatriz Luna Sara K Doll Stephen J Hegedus Nancy J Minshew John A Sweeney 《Neuropsychopharmacology》2007,61(4):474-481
BACKGROUND: Executive dysfunction has been reported at different ages in autism. It is not clear however, when this impairment emerges or how its expression is affected by development. METHODS: 61 non-mentally retarded autism participants (AUT) and 61 age, gender, and IQ matched typically developing participants (CON) were assessed with two oculomotor executive function tasks, the oculomotor delayed response task (ODR) and the antisaccade task (AS), as well as a visually-guided saccade sensorimotor task (VGS). RESULTS: The AUT group demonstrated impairments in response inhibition and spatial working memory at all ages tested. Developmental improvements in speed of sensorimotor processing and voluntary response inhibition were similar in both groups indicating sparing of some attentional control of behavior. Developmental progression in the speed of initiating a cognitive plan and maintaining information on line over time, however, was impaired in the AUT group indicating abnormal development of working memory. CONCLUSIONS: These results indicate that while executive dysfunction is present throughout development, there is evidence for both typical and atypical developmental progression of executive functions in autism. The plasticity suggested by the developmental improvements may have implications regarding appropriate developmental epochs and types of interventions aimed at enhancing cognitive capacities in individuals with autism. 相似文献
960.
John G. Freeman Oddrun Samdal Don A. Klinger Wolfgang Dur Robert Griebler Dorothy Currie Mette Rasmussen 《International journal of public health》2009,54(Z2):251-259