全文获取类型
收费全文 | 4244篇 |
免费 | 254篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 125篇 |
妇产科学 | 32篇 |
基础医学 | 557篇 |
口腔科学 | 94篇 |
临床医学 | 419篇 |
内科学 | 936篇 |
皮肤病学 | 120篇 |
神经病学 | 549篇 |
特种医学 | 153篇 |
外科学 | 686篇 |
综合类 | 68篇 |
一般理论 | 2篇 |
预防医学 | 144篇 |
眼科学 | 84篇 |
药学 | 262篇 |
中国医学 | 7篇 |
肿瘤学 | 263篇 |
出版年
2023年 | 24篇 |
2022年 | 46篇 |
2021年 | 83篇 |
2020年 | 71篇 |
2019年 | 84篇 |
2018年 | 103篇 |
2017年 | 72篇 |
2016年 | 105篇 |
2015年 | 114篇 |
2014年 | 145篇 |
2013年 | 157篇 |
2012年 | 278篇 |
2011年 | 327篇 |
2010年 | 154篇 |
2009年 | 169篇 |
2008年 | 273篇 |
2007年 | 270篇 |
2006年 | 217篇 |
2005年 | 243篇 |
2004年 | 253篇 |
2003年 | 216篇 |
2002年 | 201篇 |
2001年 | 60篇 |
2000年 | 43篇 |
1999年 | 60篇 |
1998年 | 45篇 |
1997年 | 47篇 |
1996年 | 35篇 |
1995年 | 22篇 |
1994年 | 15篇 |
1993年 | 11篇 |
1992年 | 18篇 |
1991年 | 27篇 |
1990年 | 19篇 |
1989年 | 32篇 |
1988年 | 23篇 |
1987年 | 24篇 |
1986年 | 13篇 |
1985年 | 23篇 |
1984年 | 14篇 |
1983年 | 13篇 |
1981年 | 11篇 |
1979年 | 15篇 |
1978年 | 11篇 |
1976年 | 13篇 |
1974年 | 11篇 |
1973年 | 12篇 |
1931年 | 12篇 |
1930年 | 10篇 |
1928年 | 10篇 |
排序方式: 共有4526条查询结果,搜索用时 15 毫秒
61.
62.
63.
64.
65.
66.
67.
Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites 总被引:7,自引:0,他引:7
M J Rieder J Uetrecht N H Shear M Cannon M Miller S P Spielberg 《Annals of internal medicine》1989,110(4):286-289
STUDY OBJECTIVE: To determine whether differences in in-vitro detoxification of sulfonamide-reactive metabolites can be detected among the lymphocytes from controls, patients with sulfonamide hypersensitivity reactions, and patients with nonhypersensitivity reactions to the sulfonamide agents. DESIGN: In-vitro toxicity assay on lymphocytes. SETTING: Clinics for adverse drug reactions in an adult and pediatric tertiary care center. PATIENTS: Peripheral blood lymphocytes were obtained from 46 normal volunteers and 76 patients referred to the clinic for assessment of adverse drug reactions to sulfonamide agents. Thirty-one patients had clinical histories consistent with a diagnosis of hypersensitivity reaction, whereas 45 patients had clinical histories felt to be inconsistent with a diagnosis of hypersensitivity reaction. INTERVENTIONS: Lymphocytes were assayed with tetrazolium to determine toxicity from the hydroxylamine of sulfamethoxazole. MEASUREMENTS AND MAIN RESULTS: The lymphocytes from patients with a history of hypersensitivity reactions showed markedly increased toxicity across a tenfold-concentration toxicity-concentration curve compared with those from controls and patients with a history of nonhypersensitivity reactions. These differences were highly significant (P less than 0.01). No difference was found between the toxicity shown by the lymphocytes from controls and that shown by the lymphocytes from patients with a history of nonhypersensitivity reactions. CONCLUSIONS: Metabolic differences in the production and detoxification of reactive metabolites of sulfonamide agents are important determinants of hypersensitivity reactions to these agents. These results suggest that the hydroxylamine derivative of sulfamethoxazole may be a reactive metabolite mediating these reactions. Sulfonamide hydroxylamines are useful in the diagnosis and study of the pathogenesis of hypersensitivity reactions to sulfonamide agents. 相似文献
68.
Dr. Johann Pidlich MD Friedrich Renner MD Adolf Ellinger PhD Manfred Huttinger PhD Margit Pavelka MD Alfred Gangl MD 《Digestive diseases and sciences》1996,41(7):1445-1451
The hydrophobic nonionic detergent Pluronic L-81 has been shown to lower plasma very-low-and low-density lipoprotein cholesterol, thus preventing diet-induced atherogenesis. The major effect of this agent is a pronounced interference with intestinal lipid metabolism. For studying mesenteric lymph lipoproteins during detergent exposure, a combined micromorphological and biochemical assessment of mucosa and lymph during steady-state lipid absorption was performed. Pluronic L-81 was infused intraduodenally at a constant rate in combination with mixed micellar solutions or saline in mesenteric lymph fistula rats. Pluronic L-81 impairs transepithelial lipid flux during fat absorption, trapping export lipids within the enterocytes and leading to a cytosolic and endoplasmic reticulum lipid accumulation sparing the Golgi region. Pluronic L-81 markedly (P<0.001) reduces mesenteric triglyceride, phospholipid, and total cholesterol secretion almost exclusively by a reduction of chylomicron formation. Chylomicron and very-low-density lipoprotein lipid composition was only insignificantly altered, except for somewhat higher phospholipid/triglyceride ratios. The chylomicron apoprotein pattern was almost unaffected. Thus, chylomicron formation decreased dramatically without major compositional alterations. The reduction of lipid and apoprotein secretion without particle augmentation is not in favour of a selective interference of Pluronic L-81 with intestinal apoprotein B-48 secretion.Parts of this work have been presented at the Annual Meeting of the American Gastroenterological Association, Washington, DC, May 1989, and published in abstract form (1). 相似文献
69.
70.