全文获取类型
收费全文 | 12591篇 |
免费 | 728篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 112篇 |
儿科学 | 292篇 |
妇产科学 | 173篇 |
基础医学 | 1696篇 |
口腔科学 | 270篇 |
临床医学 | 1688篇 |
内科学 | 2772篇 |
皮肤病学 | 118篇 |
神经病学 | 1058篇 |
特种医学 | 535篇 |
外科学 | 1560篇 |
综合类 | 61篇 |
一般理论 | 4篇 |
预防医学 | 1050篇 |
眼科学 | 132篇 |
药学 | 874篇 |
中国医学 | 14篇 |
肿瘤学 | 947篇 |
出版年
2024年 | 12篇 |
2023年 | 87篇 |
2022年 | 150篇 |
2021年 | 251篇 |
2020年 | 183篇 |
2019年 | 304篇 |
2018年 | 336篇 |
2017年 | 250篇 |
2016年 | 294篇 |
2015年 | 333篇 |
2014年 | 461篇 |
2013年 | 669篇 |
2012年 | 1045篇 |
2011年 | 1039篇 |
2010年 | 598篇 |
2009年 | 534篇 |
2008年 | 807篇 |
2007年 | 913篇 |
2006年 | 815篇 |
2005年 | 861篇 |
2004年 | 718篇 |
2003年 | 612篇 |
2002年 | 640篇 |
2001年 | 85篇 |
2000年 | 58篇 |
1999年 | 95篇 |
1998年 | 155篇 |
1997年 | 121篇 |
1996年 | 111篇 |
1995年 | 100篇 |
1994年 | 83篇 |
1993年 | 67篇 |
1992年 | 51篇 |
1991年 | 45篇 |
1990年 | 36篇 |
1989年 | 41篇 |
1988年 | 31篇 |
1987年 | 14篇 |
1986年 | 17篇 |
1985年 | 30篇 |
1984年 | 28篇 |
1983年 | 33篇 |
1982年 | 35篇 |
1981年 | 21篇 |
1980年 | 23篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1975年 | 14篇 |
1974年 | 10篇 |
1970年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
971.
972.
973.
Cerebrospinal fluid viral load and biomarkers of neuronal and glial cells in Ramsay Hunt syndrome 下载免费PDF全文
Johan Lindström Anna Grahn Henrik Zetterberg Marie Studahl 《The European journal of neuroscience》2016,44(11):2944-2949
Reactivation of varicella zoster virus (VZV) can manifest with facial palsy diagnosed as Ramsay Hunt Syndrome (RHS) or Ramsay Hunt Syndrome zoster sine herpete (RHS‐ZSH). These syndromes are associated with poor prognosis despite treatment with antivirals and corticosteroids. Concentrations of biomarkers such as neurofilament protein (NFL), S‐100β protein and glial fibrillary acidic protein (GFAp) have previously been measured in cerebrospinal fluid (CSF) to assess neuronal damage and glial pathology. We employed immunochemical methods to measure concentrations of NFL, S‐100β protein and GFAp in CSF from patients with RHS (n = 15) and RHS‐ZSH (n = 13) diagnosed by detection of VZV DNA in the CSF by quantitative PCR, and compared with a control group (n = 52). The biomarker concentrations were correlated with CSF viral load and outcome measured by House‐Brackmann score. NFL and GFAp concentrations were increased compared with controls (P = 0.008 and P = 0.04), while S‐100β levels were decreased. This pattern was more pronounced in patients with RHS compared to the patients with RHS‐ZSH (NS and P = 0.028). The amount of viral DNA in CSF correlated with increased GFAp (P = 0.003) and NFL (P = 0.006). No correlations were found between biomarker concentrations and patient outcome. Patients with facial palsy caused by VZV had biochemical signs of neuronal damage and astrogliosis. High amounts of viral DNA may be associated with the degree of damage on neuronal and astroglial cells. Prospective studies are warranted to elucidate the association of elevated biomarkers in the CSF and outcome assessed by more sensitive tests. 相似文献
974.
975.
976.
Leonard Frederik Kroese Jean-Francois Gillion Johannes Jeekel Johan Frederik Lange Gert-Jan Kleinrensink 《Surgery》2018,163(5):1160-1164
Background
Primary ventral hernia is a common condition. Surgical repair is associated with complications, but no clear predictive risk factors have been identified. The European Hernia Society classification offers a structured framework to describe hernias and to analyze postoperative complications. Given this structured nature, the European Hernia Society classification might prove useful for preoperative patient or treatment classification. The objective of this study was to investigate the European Hernia Society classification as a predictor for complications within 30 days after primary ventral hernia surgery.Methods
A registry-based, prospective cohort study was performed, including all patients undergoing primary ventral hernia surgery between September 1, 2011 and February 29, 2016. Univariate analyses and multivariable logistic regression analysis were performed to identify risk factors for postoperative complications.Results
A total of 2,374 patients were included, of whom 105 (4.4%) patients had ≥1 complications, either a wound, surgical, or medical complication. Factors associated with complications in univariate analyses (P?<?.10) and clinically relevant factors were included into the multivariable analyses. In the multivariable analyses, age, body mass index, and the duration of the operation were independent risk factors. The diameter of the hernia was not an independent risk factor.Conclusion
Primary ventral hernia repair is associated with a 4.4% rate of complications. No correlation was found between the European Hernia Society classification and postoperative complications. Age, body mass index, and duration of the operation were correlated with postoperative complications. Therefore, age and body mass index should be used in the preoperative risk assessment. 相似文献977.
Jeremy Sugrue Joanna Lee Christina Warner Sany Thomas Ivo Tzvetanov Winnie Mar Anders Mellgren Johan Nordenstam 《Surgery》2018,163(4):857-865
Background
Current guidelines suggest that transplant patients with acute diverticulitis should be managed aggressively with early operative intervention to reduce morbidity and mortality. This study compared the treatment choices and clinical outcomes between renal transplant patients and immunocompetent patients with acute diverticulitis.Methods
A retrospective review was performed of all patients who were admitted with acute diverticulitis between 2002 and 2015 at a single academic institution. Patient demographics, comorbidities, physiologic and radiologic disease severity, management, and disease-specific outcomes were recorded and compared between renal transplant patients and immunocompetent patients. Predictors of complications also were analyzed.Results
In the study, 20 renal transplant patients and 134 immunocompetent patients were admitted for acute diverticulitis and were followed for a median time of 36 and 40 months, respectively. Patient demographics were similar between the groups. Transplant patients had significantly more comorbidities. Overall, there were no differences in physiologic disease severity or rates of elective or urgent operation, ostomy, permanent ostomy, duration of stay, 30-day readmission, disease recurrence or disease-specific complications, organ failure, or death. Among patients with complicated disease, renal transplant patients were significantly more likely to undergo an urgent operation and had more complications. On multivariate analysis, undergoing operative therapy remained the sole predictor of complications.Conclusion
Nonoperative management of renal transplant patients who present with uncomplicated diverticulitis is safe as outcomes are similar to immunocompetent patients. However, the optimal management of renal transplant patients with complicated diverticulitis remains unclear as both treatment choices and complication rates differed from immunocompetent patients. 相似文献978.
979.
Adrie C. M. Dumay Jan J. Gerbrands Johan H. C. Reiber 《The international journal of cardiovascular imaging》1994,10(3):205-215
For clinical decision-making and documentation purposes we have developed techniques to extract, label and analyze the coronary vasculature from arteriograms in an automated, quantitative manner. Advanced image processing techniques were applied to extract and analyze the vasculatures from non-subtracted arteriograms while artificial intelligence techniques were employed to assign anatomical labels. Lumen diameters of 11 phantom vessels were assessed with an accuracy of 0.27±0.19 mm (d true = 0.45 + 0.92d measured ; r> 0.99) and 0.21±0.15 mm (d true =0.42+0.91d measured ; r> 0.99), from cine and digital images, respectively. We collected a total of 15 routinely acquired cine-arteriograms showing 74 vessel segments with 18 stenoses (severity larger than 30% assessed quantitatively), and 53 digital arteriograms showing 236 vessel segments with 69 stenoses. From the cine arteriograms we extracted 64 (86%) of the vessel segments without manual correction and 196 (83%) from the digital arteriograms. Repeated analysis (3 times) of the arteriograms by the same operator resulted in a standard deviation of the mean segment diameters (precision) of 0.064 mm for the cine-images and 0.020 mm for the digital images, while the standard deviations in the measurement of the minimal luminal diameter of the observed stenoses were 0.020 mm and 0.019 mm, respectively. The LAD artery, the septal and diagonal branches were correctly identified automatically in 86% of the segments. From these evaluations we conclude that our automated approach provides reliable tools for the assessment of multi-vessel disease, both in an offand on-line environment. 相似文献