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排序方式: 共有889条查询结果,搜索用时 15 毫秒
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Talbi C Cabon J Baud M Bourjaily M de Boisséson C Castric J Bigarré L 《Archives of virology》2011,156(12):2133-2144
Despite the increasing impact of rhabdoviruses in European percid farming, the diversity of the viral populations is still
poorly investigated. To address this issue, we sequenced the partial nucleoprotein (N) and complete glycoprotein (G) genes
of nine rhabdoviruses isolated from perch (Perca fluviatilis) between 1999 and 2010, mostly from France, and analyzed six of them by immunofluorescence antibody test (IFAT). Using two
rabbit antisera raised against either the reference perch rhabdovirus (PRhV) isolated in 1980 or the perch isolate R6146,
two serogroups were distinguished. Meanwhile, based on partial N and complete G gene analysis, perch rhabdoviruses were divided
into four genogroups, A-B-D and E, with a maximum of 32.9% divergence (G gene) between isolates. A comparison of the G amino
acid sequences of isolates from the two identified serogroups revealed several variable regions that might account for antigenic
differences. Comparative analysis of perch isolates with other rhabdoviruses isolated from black bass, pike-perch and pike
showed some strong phylogenetic relationships, suggesting cross-host transmission. Similarly, striking genetic similarities
were shown between perch rhabdoviruses and isolates from other European countries and various ecological niches, most likely
reflecting the circulation of viruses through fish trade as well as putative transfers from marine to freshwater fish. Phylogenetic
relationships of the newly characterized viruses were also determined within the family Rhabdoviridae. The analysis revealed a genetic cluster containing only fish viruses, including all rhabdoviruses from perch, as well as
siniperca chuatsi rhabdovirus (SCRV) and eel virus X (EVEX). This cluster was distinct from the one represented by spring
viraemia of carp vesiculovirus (SVCV), pike fry rhabdovirus (PFRV) and mammalian vesiculoviruses. The new genetic data provided
in the present study shed light on the diversity of rhabdoviruses infecting perch in France and support the hypothesis of
circulation of these viruses between other hosts and regions within Europe. 相似文献
74.
Kaya F Belin S Bourgeois P Micaleff J Blin O Fontés M 《Neuromuscular disorders : NMD》2007,17(3):248-253
Charcot-Marie-Tooth [CMT] syndrome is the most common hereditary peripheral neuropathy. CMT1A, which accounts for 50% of all CMT cases, usually results from triploidy of the PMP22 gene. Preclinical trials using an animal model show that disabled mice force-fed with high doses of ascorbic acid partially recover muscular strength after a few months of treatment, and suggest that high doses of ascorbic acid repress PMP22 expression. In this study, we demonstrated that ascorbic acid represses PMP22 gene expression by acting on intracellular cAMP levels and adenylate cyclase activity. This action is dose dependent and specific to ascorbic acid, since repression is not observed after treatment with other antioxidants. The new properties of ascorbic acid are discussed, along with the implications of these findings for CMT disease treatment. 相似文献
75.
van den Wildenberg E Wiers RW Dessers J Janssen RG Lambrichs EH Smeets HJ van Breukelen GJ 《Alcoholism, clinical and experimental research》2007,31(1):1-10
BACKGROUND: The mu-opioid receptor gene (OPRM1) codes for the mu-opioid receptor, which binds beta-endorphin. The A118G polymorphism in this gene affects beta-endorphin binding such that the Asp40 variant (G allele) binds beta-endorphin 3 times more tightly than the more common Asn40 variant (A allele). This study investigated the influence of the A118G polymorphism on cue reactivity after exposure to an alcoholic beverage in male heavy drinkers. METHODS: Participants were either homozygous for the A allele (n=84) or carrying at least 1 copy of the G allele (n=24). All participants took part in a cue-reactivity paradigm where they were exposed to water and beer in 3-minute trials. The dependent variables of main interest were subjective craving for alcohol, subjective arousal, and saliva production. RESULTS: G allele carriers reported significantly more craving for alcohol than the A allele participants (as indicated by the within-subject difference in craving after beer vs after water exposure). No differences were found for subjective arousal and saliva. Both groups did not differ in family history of alcoholism. Participants with the G allele reported a significantly higher lifetime prevalence of drug use than participants homozygous for the A allele. CONCLUSIONS: A stronger urge to drink alcohol after exposure to an alcoholic beverage might contribute to a heightened risk for developing alcohol-related problems in individuals with a copy of the G allele. The G allele might also predispose to drug use in general. 相似文献
76.
Ish-Hurwitz S Dovrish Z Edelstein E Bernheim J Bernheim J Hadari R Amital H 《Rheumatology international》2007,28(1):65-68
Severe granulocytopenia predispose patients with Felty’s syndrome to severe infectious diseases. The following report deals
with an occurrence of chronic disseminated candidiasis in a patient with Felty’s syndrome who presented with prolonged and
severe granulocytopenia. To the best of our knowledge this coexistence has never been described before.
Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. 相似文献
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Charbotel B Croidieu S Vohito M Guerin AC Renaud L Jaussaud J Bourboul C Imbard I Ardiet D Bergeret A 《International archives of occupational and environmental health》2009,82(6):747-756
Purpose The present study sought to assess the impact of telephone call center employees’ working conditions on health by identifying
at-risk employment situations.
Methods A transversal study was performed in companies followed by 47 occupational physicians taking part (working conditions have
been previously described). A self-administered medical questionnaire was used to collect data on absence due to sick leave,
hearing and visual problems, musculoskeletal disorders, psychotropic drug use, etc. An analog-scale self-assessment of health
status and a general health questionnaire (GHQ-12) were used. Personal or familial events that might underlie health problems
and affect GHQ-12 results were quantified and taken into account in a logistic regression.
Results A total of 2,130 call-handlers were included. Workers who had availed sick leave during the previous 12 months were 60%. The
most frequent musculoskeletal complaints over the previous 12-month period concerned the cervical region (59%). During the
same period, 77.3% of subjects experienced visual fatigue, 50% reported auditory fatigue signs and 47% vocal disturbance or
fatigue. According to the Likert scale, 39.4% of workers had showed psychological distress. Almost 24% of the workers had
used psychoactive medication during the previous 12 months. A significant association was found between psychological distress
and the frequency of musculoskeletal disorders. Psychological distress and musculoskeletal disorders were significantly greater
in workers with Job Strain and Iso Strain.
After taking non-occupational factors into account, some occupational factors were found to increase the risk of psychological
distress (Likert >12): imposed full-time schedule, being unable to simultaneously meet both quality and quantity requirements,
situations of tension with clients, negative comments from superiors, and lack of recognition from superiors.
Conclusions This survey of over 2,000 call center employees highlighted the high frequency of psychological distress in this population
and the health impact of working conditions.
Legal agreements Approval by the French Ministry of Research (Comité consultatif pour le traitement de l’information en matière de recherche dans le domaine de la santé) and the French data protection authority (Commission Nationale de l’Informatique et des Libertés) was obtained before starting the study. 相似文献