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71.
BCR‐ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next‐generation sequencing 下载免费PDF全文
72.
Suhad S. AbuMweis Christopher P.F. Marinangeli Jiri Frohlich Peter J.H. Jones 《The Canadian journal of cardiology》2014
More than 200 clinical trial reports and several meta-analyses have demonstrated that phytosterols (PSs), natural components of plants, induce clinically relevant reductions in blood low-density lipoprotein cholesterol levels. Here we review data regarding the biochemical effects and potential cardiovascular benefit of PSs as part of the dietary management of dyslipidemia. In addition to discussing the efficacy, effectiveness, and safety of PSs as hypocholesterolemic agents, this review provides an overview of PSs as an adjunctive therapy to cholesterol-lowering pharmaceuticals. Given this lack of evidence regarding the benefits of PSs for reducing cardiovascular end points, this review also discusses the present knowledge that exists about the ability for therapeutic dosages of PSs to confer protection from cardiovascular-related mortality and morbidity. Finally, this review summarizes the factors that affect PS efficacy and the Canadian regulations that govern the use of PSs as cholesterol-lowering agents in foods and supplements. 相似文献
73.
Lucie Kalisova Jiri Raboch Alexander Nawka Gaia Sampogna Libor Cihal Thomas W. Kallert Georgi Onchev Anastasia Karastergiou Valeria del Vecchio Andrzej Kiejna Tomasz Adamowski Francisco Torres-Gonzales Jorge A. Cervilla Stephan Priebe Domenico Giacco Lars Kjellin Algirdas Dembinskas Andrea Fiorillo 《Social psychiatry and psychiatric epidemiology》2014,49(10):1619-1629
Purpose
This study aims to identify whether selected patient and ward-related factors are associated with the use of coercive measures. Data were collected as part of the EUNOMIA international collaborative study on the use of coercive measures in ten European countries.Methods
Involuntarily admitted patients (N = 2,027) were divided into two groups. The first group (N = 770) included patients that had been subject to at least one of these coercive measures during hospitalization: restraint, and/or seclusion, and/or forced medication; the other group (N = 1,257) included patients who had not received any coercive measure during hospitalization. To identify predictors of use of coercive measures, both patients’ sociodemographic and clinical characteristics and centre-related characteristics were tested in a multivariate logistic regression model, controlled for countries’ effect.Results
The frequency of the use of coercive measures varied significantly across countries, being higher in Poland, Italy and Greece. Patients who received coercive measures were more frequently male and with a diagnosis of psychotic disorder (F20–F29). According to the regression model, patients with higher levels of psychotic and hostility symptoms, and of perceived coercion had a higher risk to be coerced at admission. Controlling for countries’ effect, the risk of being coerced was higher in Poland. Patients’ sociodemographic characteristics and ward-related factors were not identifying as possible predictors because they did not enter the model.Conclusions
The use of coercive measures varied significantly in the participating countries. Clinical factors, such as high levels of psychotic symptoms and high levels of perceived coercion at admission were associated with the use of coercive measures, when controlling for countries’ effect. These factors should be taken into consideration by programs aimed at reducing the use of coercive measures in psychiatric wards. 相似文献74.
75.
Magda Vytrisalova Leos Fuksa Vladimir Palicka Svatopluk Byma Sarka Blazkova Jan Stepan Tereza Hendrychova Jiri Vlcek Petr Pavek 《Central European Journal of Medicine》2014,9(5):687-693
Rationale and objectives
General practitioners (GPs) play an important role in management of patients at risk of osteoporosis (OP). The objectives were to assess (1) knowledge about OP and use of OP clinical guideline in comparison with other information sources and (2) association between the use of individual information sources and knowledge and self-reported quality of care among GPs.Methods
Survey among random sample of Czech GPs was performed to find out their attitudes and role in OP management. The return rate of the postal questionnaire was 38% (525 respondents). Quality of care was assessed using three indicators: suspicion on OP, referral to the specialist and initial check-up.Results
Respondents (median age 52 years, 59% women) had a very good knowledge of several risk factors, while others, namely low body mass index, history of hip fracture in mother and smoking were perceived as risk factors by only 40%, 45% and 55% of respondents, respectively. 10% of GPs stated the correct answer regarding daily calcium intake recommended for postmenopausal women. The OP guideline was considered accessible by 83% of respondents and used repeatedly by 54%. Use of the guideline correlated positively with knowledge score (P < 0.001), while use of each individual other source of information did not. Use of the guideline correlated with all three indicators of quality of care. Use of each other information source correlated only with a maximum of two indicators.Conclusion
We identified areas of insufficient knowledge that should be targeted in educational activities for GPs. It is recommended to further motivate GPs to use their clinical guidelines regularly. 相似文献76.
Jakub Trizuljak Wolfgang R. Sperr Lucie Nekvindová Hanneke O. Elberink Karoline V. Gleixner Aleksandra Gorska Magdalena Lange Karin Hartmann Anja Illerhaus Massimiliano Bonifacio Cecelia Perkins Chiara Elena Luca Malcovati Anna B. Fortina Khalid Shoumariyeh Mohamad Jawhar Roberta Zanotti Patrizia Bonadonna Francesca Caroppo Alexander Zink Massimo Triggiani Roberta Parente Nikolas von Bubnoff Akif S. Yavuz Hans Hägglund Mattias Mattsson Jens Panse Nadja Jäkel Alex Kilbertus Olivier Hermine Michel Arock David Fuchs Vito Sabato Knut Brockow Agnes Bretterklieber Marek Niedoszytko Björn van Anrooij Andreas Reiter Jason Gotlib Hanneke C. Kluin-Nelemans Jiri Mayer Michael Doubek Peter Valent 《Allergy》2020,75(8):1927-1938
77.
Martina Lengerova Zdenek Racil Kristyna Hrncirova Iva Kocmanova Pavlina Volfova Dita Ricna Petr Bejdak Mojmir Moulis Zdenek Pavlovsky Barbora Weinbergerova Martina Toskova Jiri Mayer 《Journal of clinical microbiology》2014,52(8):2824-2828
Rapid differential diagnostics of pulmonary infiltrates suspected of invasive fungal disease in an immunocompromised host and early initiation of effective antifungal therapy are crucial for patient outcomes. There are no serological tests available to detect mucormycetes; therefore, PCR-based methods are highly suitable. We validated our previously published PCR followed by high-resolution melt analysis (PCR/HRMA) to detect Rhizopus spp., Rhizomucor pusillus, Lichtheimia corymbifera, and Mucor spp. in bronchoalveolar lavage (BAL) samples from immunocompromised patients who were at risk of invasive fungal disease. All PCR/HRMA-positive samples were retested using novel real-time quantitative PCR (RQ PCR) assays specific to the species identified. In total, between January 2009 and December 2012 we analyzed 99 BAL samples from 86 patients with pulmonary abnormalities using PCR/HRMA. Ninety (91%) BAL samples were negative, and 9 (9%) samples were positive. The sensitivity and specificity of PCR/HRMA were 100% and 93%, respectively. By combining the positive results of PCR/HRMA with positive RQ PCR results, the specificity was raised to 98%. PCR/HRMA, due to its high negative predictive value (99%), represents a fast and reliable tool for routine BAL sample screening for the differential diagnosis of pulmonary infiltrates in immunocompromised patients for the four most clinically important mucormycetes. 相似文献
78.
Fabrice Fekam Boyom Eugénie Madiesse Kemgne Roselyne Tepongning Vincent Ngouana Wilfred Fon Mbacham Etienne Tsamo Paul Henri Amvam Zollo Jiri Gut Philip J. Rosenthal 《Journal of ethnopharmacology》2009
Aim of the study
In a search for new plant-derived biologically active compounds against malaria parasites, we have carried out an ethnopharmacological study to evaluate the susceptibility of cultured Plasmodium falciparum to extracts and fractions from seven Cameroonian medicinal plants used in malaria treatment. We have also explored the inhibition of the Plasmodium falciparum cysteine protease Falcipain-2.Materials and methods
Plant materials were extracted by maceration in organic solvents, and subsequently partitioned or fractionated to afford test fractions. The susceptibility of erythrocytes and the W2 strain of Plasmodium falciparum to plant extracts was evaluated in culture. In addition, the ability of annonaceous extracts to inhibit recombinant cysteine protease Falcipain-2 was also assessed.Results and discussion
The extracts showed no toxicity against erythrocytes. The majority of plant extracts were highly active against Plasmodium falciparumin vitro, with IC50 values lower than 5 μg/ml. Annonaceous extracts (acetogenin-rich fractions and interface precipitates) exhibited the highest potency. Some of these extracts exhibited modest inhibition of Falcipain-2.Conclusion
These results support continued investigation of components of traditional medicines as potential new antimalarial agents. 相似文献79.
Jiri Dvorak Petr Kral Andrey G. Kadomtsev Vladimir I. Betekhtin Maria V. Narykova Marie Kvapilova Vaclav Sklenicka 《Materials》2022,15(5)
The commercial purity of VT1-0 titanium was processed by the rolling process and executed at elevated, room, and cryo-temperatures. These processings led to the formation of an ultrafine-grained microstructure, with the mean grain size at a nanometer level. Some of these materials were statically annealed at a temperature of 823 K for 1 h, which led to significant subgrains and grain coarsening. The constant load creep tests in tension were carried out in argon on all states of materials, at temperatures of 648–723 K and different ranges of applied stresses. From the value of the steady-state creep rate, the control creep mechanisms were determined. The microstructure analyses were carried out via SEM and TEM. It was found that titanium prepared at elevated and room temperatures have a higher creep strength than titanium prepared at cryo-temperatures. Furthermore, the post-SPD —annealing led to a significant decrease in the creep properties. The influence of the preparation temperature on the difference of the creep behavior were discussed and explained using the microstructure analyses of the tests’ samples. 相似文献
80.
Jiri Kassa Jan Misik Jana Z. Karasova 《Basic & clinical pharmacology & toxicology》2013,113(3):201-208
The ability of two newly developed bispyridinium oximes (K456, K458) to reduce tabun‐induced acute neurotoxic signs and symptoms was compared with oxime K203 and trimedoxime using the functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (200 μg/kg i.m.; 85% of LD50 value) were evaluated. Tabun‐induced neurotoxicity was monitored by the functional observational battery and automatic measurement of motor activity at 2 hr after tabun challenge. The results indicate that all tested oximes combined with atropine enable tabun‐poisoned rats to survive till the end of experiment. Both newly developed oximes (K456, K458) combined with atropine were able to decrease tabun‐induced neurotoxicity in the case of sublethal poisonings although they did not eliminate all tabun‐induced acute neurotoxic signs and symptoms. Their ability to decrease tabun‐induced acute neurotoxicity was slightly higher than that of trimedoxime and oxime K203, but the difference in neuroprotective efficacy among all oximes studied is not large enough to make a decision about replacement of commonly used oximes (especially trimedoxime and obidoxime) in the treatment of acute tabun poisonings. 相似文献