TPF方案诱导化疗加同期调强放化疗治疗晚期鼻咽癌的临床观察

目的:探讨TPF方案诱导化疗结合同期调强放化疗治疗局部区域晚期鼻咽癌的有效剂量及近期疗效.方法:Docetaxel与DDP剂量60 mg/m2,静脉滴入;5-FU初始剂量450 mg/(m2·d),持续120 h静脉灌注,按50 mg/(m2·d)剂量递增,根据剂量递增法则确定其最大耐受剂量(MTD),观察终点为出现剂量限制性毒性(DLT).每位患者行3个周期诱导化疗,每个周期化疗间隔3周,第3个周期化疗后3周给予调强放疗(IMRT)加上同期DDP 80 mg/m2化疗.结果:12例患者共完成了450～550 mg/(m2·d)3个剂量水平共34个周期诱导化疗.在550 mg/(m2·d)剂量水平,1例患者出现3度黏膜反应及4度腹泻的DLT,按既定方案再以此剂量依次治疗3例患者,未再发生DLT,该剂量水平即为MTD.除1例DLT患者停止诱导化疗外,余11例患者均行3个周期诱导化疗,3个周期诱导化疗后总反应率(OR)100%,完全缓解率(CR)64%(7/11).12例患者均完成同期放化疗,诱导化疗未加重同期放化疗的毒副反应.结论:TPF方案在Docetaxel 60 mg/m2、DDP 60 mg/m2剂量前提下治疗局部区域晚期鼻咽癌,5-FU的 MTD为550 mg/(m2·d),该方案具有较高近期反应率.     

Vesical instillations of hyaluronic acid to reduce the acute vesical toxicity caused by high-dose brachytherapy do not affect the survival: a five-year follow-up study

Objective  

To determine whether the intravesical use of hyaluronic acid (HA) reduces acute and late vesical toxicity induced by radiotherapy.     

乌梅丸方证涵义及应用

乌梅丸寒热互济,辛甘酸苦并用,具有补泻兼施、温清并举、气血两调的特点。此方原为治疗蛔厥而设,其作用机制重在温脏补虚以安蛔,并非直接驱杀蛔虫。乌梅丸证症状上寒热并见,可表现为内热外寒或上热下寒,其病机总为本虚标实,以虚寒为本,邪实为标。厥阴提纲证非外感所致,乃肝家郁导致的上热下寒证。乌梅丸证,可得于“伤寒”,亦可得于“内伤杂病”。得于“内伤杂病”者,亦由肝家郁使然,其来也渐。     

化精汤治疗精液不液化症160例临床观察

目的:观察化精汤治疗精液不液化症的临床疗效.方法:将160例精液不液化症患者按随机数字表法分为治疗组(80例)和对照组(80例),治疗组采用化精汤(败酱草、黄柏、白花蛇舌草、虎杖、赤芍、穿山甲等)治疗,对照组采用维生素C片治疗.结果:治疗组总有效率87.5%,对照组总有效率52.5%,治疗组明显优于对照组(P<0.05).结论:化精汤治疗精液不液化症效果良好.     

Clinical experience on treatment of cervical spondylosis with combined acupuncture, tuina and psychotherapy

Cervical spondylosis is common in the middleaged or senile population and can greatly affect their body-mind health. The common treatment methods include traction, tuina, acupuncture and medication. However, psychological factors, such as anxiety, depression or fear are often neglected during the treatment. The authors investigated the effect of combined psycho- therapy, acupuncture and tuina on the cervical spondylosis.     

中西医结合治疗梅尼埃病98例临床观察

目的观察中西医结合治疗梅尼埃病的临床疗效。方法将98例患者随机分为2组,治疗组65例,采用中西医结合治疗,对照组33例以西药治疗。结果显效率、总有效率对照组分别为36.4%、84.8%,治疗组分别为81.5%、96.9%,2组比较,差异有非常显著性意义(P0.01)。结论中西医结合治疗梅尼埃病优于西药治疗。     

Down‐regulation of microglia and NG2‐positive cells reaction in trimethyltin‐injured hippocampus of rats treated with myelin basic protein‐reactive T cells: Possible contribution to the neuroprotective effect of T cells

In our previous investigations, we demonstrated that CD4⁺ antimyelin basic protein (MBP) T cells protect hippocampal neurons against trimethyltin‐induced damage. We hypothesized involvement of T cells, interacting with the various glial populations activated during the neurodegeneration process. In this study, we employ immunocytochemical methods to investigate the influence of administration of T cells on the response of microglia and of NG2⁺ cells to trimethyltin (TMT)‐induced damage. Female Lewis rats were treated with anti‐MBP CD4⁺ T cells (4 million per animal, i.v) 24 hr after TMT (8 mg/kg, i.p) intoxication. TMT caused degeneration of CA4 hipppocampal neurons and evoked an abundant reaction of microglial and NG2⁺ cells in the injured region. The cells changed morphology into the activated state, and the number of OX42⁺ and NG2⁺ cells increased about 4.5‐fold and 3‐fold, respectively, relative to controls as assessed on day 21 after TMT treatment. Additionally, the cells of ameboid morphology, which expressed NG2 or microglial antigens, appeared in the zone of neurodegeneration. Furthermore, certain cells of ameboid phenotype shared both antigens. In rats treated with T cells, down‐regulation of the activation of both glial classes and reduction of formation of their ameboid forms was observed. The number of the total OX42⁺ and NG2⁺ cells decreased by 21% and 54%, respectively, and the number of their ameboid forms decreased by 46% and 73%, respectively. Our data suggest that the diminished activation of microglia and NG2⁺ cells, particularly the reduced number of their ameboid forms, may contribute to the neuroprotective effect of T cells. © 2009 Wiley‐Liss, Inc.